Glaucoma is the second leading cause of blindness worldwide. The clinical standard for monitoring the functional deficits in the retina that are caused by glaucoma is the visual field test. In addition to monitoring the functional loss, evaluating the disease-related structural changes in the human retina also helps with diagnosis and management of this progressive disease. The characteristic changes of retinal structures such as the optic nerve head (ONH) are monitored utilizing imaging modalities such as color (stereo) fundus photography and, more recently, spectral-domain optical coherence tomography (SD-OCT). With the inherent subjectivity and time required for manually segmenting retinal structures, there has been a great interest in automated approaches. Since both fundus and SD-OCT images are often acquired for the assessment of glaucoma, the automated segmentation approaches can benefit from combining the multimodal complementary information from both sources. The goal of the current work is to automatically segment the retinal structures and extract the proper parameters of the optic nerve head related to the diagnosis and management of glaucoma. The structural parameters include the cup-to-disc ratio (CDR) which is a 2D parameter and is obtainable from both fundus and SD-OCT modalities. Bruch's membrane opening-minimum rim width (BMO-MRW) is a recent 3D structural parameter that is obtainable from the SD-OCT modality only. We propose to use the complementary information from both fundus and SD-OCT modalities in order to enhance the segmentation of structures of interest. In order to enable combining information from different modalities, a feature-based registration method is proposed for aligning the fundus and OCT images. In addition, our goal is to incorporate the machine-learning techniques into the graph-theoretic approach that is used for segmenting the structures of interest. Thus, the major contributions of this work include: 1) use of complementary information from SD-OCT and fundus images for segmenting the optic disc and cup boundaries in both modalities, 2) identifying the extent that accounting for the presence of externally oblique border tissue and retinal vessels in rim-width-based parameters affects structure-structure correlations, 3) designing a feature-based registration approach for registering multimodal images of the retina, and 4) developing a multimodal graph-based approach to segment the optic nerve head (ONH) structures such as Internal Limiting Membrane (ILM) surface and Bruch's membrane surface's opening.

<p>Disertacija se bavi analizom uticaja raspodela podataka na rezultate algoritama diskretizacije u okviru procesa ma&scaron;inskog učenja. Na osnovu izabranih baza i algoritama diskretizacije teorije grubih skupova i stabala odlučivanja, istražen je uticaj odnosa raspodela podataka i tačaka reza određene diskretizacije.<br />Praćena je promena konzistentnosti diskretizovane tabele u zavisnosti od položaja redukovane tačke reza na histogramu. Definisane su fiksne tačke reza u zavisnosti od segmentacije multimodal raspodele, na osnovu kojih je moguće raditi redukciju preostalih tačaka reza. Za određivanje fiksnih tačaka konstruisan je algoritam FixedPoints koji ih određuje u skladu sa grubom segmentacijom multimodal raspodele.<br />Konstruisan je algoritam aproksimativne diskretizacije APPROX MD za redukciju tačaka reza, koji koristi tačke reza dobijene algoritmom maksimalne razberivosti i parametre vezane za procenat nepreciznih pravila, ukupni procenat klasifikacije i broj tačaka redukcije. Algoritam je kompariran u odnosu na algoritam maksimalne razberivosti i u odnosu na algoritam maksimalne razberivosti sa aproksimativnim re&scaron;enjima za &alpha;=0,95.</p> / <p>This dissertation analyses the influence of data distribution on the results of discretization algorithms within the process of machine learning. Based on the chosen databases and the discretization algorithms within the rough set theory and decision trees, the influence of the data distribution-cuts relation within certain discretization has been researched.<br />Changes in consistency of a discretized table, as dependent on the position of the reduced cut on the histogram, has been monitored. Fixed cuts have been defined, as dependent on the multimodal segmentation, on basis of which it is possible to do the reduction of the remaining cuts. To determine the fixed cuts, an algorithm FixedPoints has been constructed, determining these points in accordance with the rough segmentation of multimodal distribution.<br />An algorithm for approximate discretization, APPROX MD, has been constructed for cuts reduction, using cuts obtained through the maximum discernibility (MD-Heuristic) algorithm and the parametres related to the percent of imprecise rules, the total classification percent and the number of reduction cuts. The algorithm has been compared to the MD algorithm and to the MD algorithm with approximate solutions for &alpha;=0,95.</p>