In the skeletal muscle cell membrane, the voltage gated chloride channel, CIC-1, maintains as unusually high resting membrane conductance and thereby prevents myotonic skeletal muscle disease. Protein crystallization experiments with bacterial CIC proteins, provide the information for the three dimensional (3D) structure of CIC chloride channels. / Thesis (PhDBiomedicalScience)--University of South Australia, 2003.

Diss. (sammanfattning) Stockholm : Karol. inst., 2006. / Härtill 4 uppsatser.

Thesis (Ph. D.)--West Virginia University, 2008. / Title from document title page. Document formatted into pages; contains ix, 133 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 96-110).

Thesis (MHSc--Health Science) -- AUT University, 2008. / Includes bibliographical references. Also held in print (185 leaves : ill. ; 30 cm.) in the Archive at the City Campus (T 615.8515 MCK)

Thesis (Ph.D.)--Aberdeen University, 2009. / Title from web page (viewed on Mar. 30, 2010). Includes bibliographical references.

Thesis (Ph. D.)--University of Wisconsin--Madison, 1967. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Theses (M.S)--Marshall University, 2007. / Title from document title page. Includes abstract. Document formatted into pages: contains vii, 96 pages. Bibliography: p.87-92.

Thesis (Ph. D.)--University of Texas at Austin, 2007. / Vita. Includes bibliographical references.

Over 7 million participants play rugby union throughout over 120 countries. Despite this global status, very little is known about the longer-term health outcomes of players, or how health and health-related quality of life are influenced by participation in rugby union. The aim of this thesis was to design and undertake an epidemiological study to assess overall health, the presence of morbidity, and development of osteoarthritis within former elite rugby players. In addition to establishing a study, and assessing health and morbidity, secondary aims were to compare the prevalence of morbidity in this population with age-matched representative population-based survey participants, and to examine risk factors associated with the development of osteoarthritis in this population. A cross-sectional questionnaire study was designed to assess physician-diagnosed morbidity, playing exposure, injury history and current health status. Former rugby players for Oxford and Cambridge Universities, and members of the England Rugby Internationals Club, were invited to participate in this study. Data from the English Longitudinal Study of Ageing (ELSA) and the Health Survey for England (HSE) were used as population-based representative comparator groups. These four studies examine the feasibility of involving rugby players in sport-related healthcare research, the prevalence of morbidity and health-related quality of life relative to the general population, the prevalence and risk factors for osteoarthritis-related outcomes, and finally develop a prediction model of end-stage hip failure in this population. Involving players throughout the research cycle as experts of their own experience was seen to influence the research process and questionnaire development, and ensured this process was grounded in players' beliefs and experiences. In terms of physician-diagnosed morbidity, former players were seen to demonstrate less diabetes than ELSA participants, but more osteoporosis, anxiety, osteoarthritis (OA) and joint replacement. Risk factors for osteoarthritis-related outcomes were seen to vary between the knee, hip and shoulder, and between the definitions of osteoarthritis used (NHANES pain, physician-diagnosed OA or joint replacement). Joint-specific injury was most highly associated with osteoarthritis across all joints and definitions used. The prediction model for hip replacement was strong (AUC 0.88), despite the relatively small development dataset, and again emphasised injury, in addition to Slipped Upper Femoral Epiphysis, age, family history, and playing in the second row, as predictive of hip replacement. This was not externally validated, however internal validation was undertaken. This work has not only established health outcomes in this population, and developed the methodology and survey tools to replicate this work in other cohorts, but also assesses risk factors and strongly predicts poor OA outcome in this population. This work presents potential intervention opportunities for the sport to begin to address the now quantified health deficits; and also presents benefits of elite contact sports participation. These findings should support efforts to ensure healthy participation and adequate proactive management of health at the elite level, for all players.

Low back pain (LBP) is a common condition that affects all age groups and sexes. Although the development of LBP is multifactorial, the performance of lifting-based manual material handling (MMH) tasks are recognized as a primary risk factor. Many occupations that involve MMH tasks are performed in hazardous environments, where personal protective equipment (PPE) must be worn. Among the most commonly prescribed forms of PPE in Canada are CSA Grade 1 steel-toed work boots. According to the hazards present on the jobsite, workers may need to wear steel-toed work boots with/without a metatarsal guard or be able to wear steel-toed shoes (no upper). However, the amount of research on the interaction between protective footwear and human motion is limited. Therefore, the purpose of this thesis was to assess the effects of steel-toed shoes (unlaced), steel-toed boots (work boot), and steel-toed boots with a metatarsal guard (MET) on lifting mechanics. Specifically, three-dimensional kinematics of the lower limbs and trunk, sagittal net reaction moments of the low back, and local dynamic stability (LDS) of the lower limbs, lower back, and upper back were analyzed. Twelve males and 12 females were recruited to participate in this research project. Participants performed a repetitive lifting task at 10% of their maximum back strength, under three block-randomized footwear conditions. Ankle dorsiflexion was negatively affected by footwear type, where dorsiflexion was reduced the most in the MET condition compared to the unlaced condition (p < 0.01). However, there were no other main effects of footwear type on any other variable tested, and both male and female participants were able to maintain similar lifting mechanics and LDS values when moving up the kinematic chain. It is possible that participants were able to preserve their kinematics and stability through the appropriate recruitment of muscles, which may have implications for an increase in compressive and shear force on the spine and should be explored further in the future.