Abstract: Highway bridges have great values in a country because in case of any natural disaster they may serve as lines to save people’s lives. Being vulnerable under significant seismic loads, different methods can be considered to design resistant highway bridges and rehabilitate the existing ones. In this study, base isolation has been considered as one efficient method in this regards which in some cases reduces significantly the seismic load effects on the structure. By reducing the ductility demand on the structure without a notable increase of strength, the structure is designed to remain elastic under seismic loads. The problem associated with the isolated bridges, especially with elastomeric bearings, can be their excessive displacements under service and seismic loads. This can defy the purpose of using elastomeric bearings for small to medium span typical bridges where expansion joints and clearances may result in significant increase of initial and maintenance cost. Thus, supplementing the structure with dampers with some stiffness can serve as a solution which in turn, however, may increase the structure base shear. The main objective of this thesis is to provide a simplified method for the evaluation of optimal parameters for dampers in isolated bridges. Firstly, performing a parametric study, some directions are given for the use of simple isolation devices such as elastomeric bearings to rehabilitate existing bridges with high importance. Parameters like geometry of the bridge, code provisions and the type of soil on which the structure is constructed have been introduced to a typical two span bridge. It is concluded that the stiffness of the substructure, soil type and special provisions in the code can determine the employment of base isolation for retrofitting of bridges. Secondly, based on the elastic response coefficient of isolated bridges, a simplified design method of dampers for seismically isolated regular highway bridges has been presented in this study. By setting objectives for reduction of displacement and base shear variation, the required stiffness and damping of a hysteretic damper can be determined. By modelling a typical two span bridge, numerical analyses have followed to verify the effectiveness of the method. The method has been used to identify equivalent linear parameters and subsequently, nonlinear parameters of hysteretic damper for various designated scenarios of displacement and base shear requirements. Comparison of the results of the nonlinear numerical model without damper and with damper has shown that the method is sufficiently accurate. Finally, an innovative and simple hysteretic steel damper was designed. Five specimens were fabricated from two steel grades and were tested accompanying a real scale elastomeric isolator in the structural laboratory of the Université de Sherbrooke. The test procedure was to characterize the specimens by cyclic displacement controlled tests and subsequently to test them by real-time dynamic substructuring (RTDS) method. The test results were then used to establish a numerical model of the system which went through nonlinear time history analyses under several earthquakes. The outcome of the experimental and numerical showed an acceptable conformity with the simplified method. / Résumé: Les ponts routiers ont une grande valeur dans un pays parce qu’en cas de catastrophe naturelle, ils peuvent servir comme des lignes pour sauver des vies. Étant vulnérable sous des charges sismiques importantes, on peut considérer différentes méthodes pour concevoir des ponts routiers résistants et également pour réhabiliter des ponts existants. Dans cette étude, l'isolation de la base a été considérée comme une méthode efficace qui peut réduire significativement les effets des charges sismiques sur la structure. En réduisant la demande en ductilité sur la structure sans une augmentation notable de force, la structure est conçue pour rester élastique sous des charges sismiques. Le problème associé aux ponts isolés, particulièrement avec des appuis en élastomère, peut être leurs déplacements excessifs sous les charges de service et de séisme. Ceci peut défier l’objectif d'utiliser des appuis en élastomère pour les ponts typiques de petite portée où les joints de dilatation et les dégagements peuvent aboutir à une augmentation significative des frais d'exploitation et de maintenance. Ainsi, supplémenter la structure avec des amortisseurs d’une certaine rigidité peut servir de solution, ce qui peut cependant augmenter l’effort tranchant transmis à la sous-structure. Cette étude a pour but de fournir une méthode simplifiée afin d’évaluer les paramètres optimaux des amortisseurs dans les ponts isolés. Dans cette thèse, premièrement, basé sur une étude paramétrique, quelques directions sont données pour l'utilisation de dispositifs d'isolation simples, dont les appuis en élastomère, afin de réhabiliter des ponts existant avec une haute importance. Les paramètres comme la géométrie du pont, les clauses des normes et le type de sol sur lequel la structure est construite ont été appliqués sur un pont typique de deux portées. Il est conclu que les paramètres mentionnés peuvent déterminer l'emploi d'isolement de la base des ponts routiers. À la deuxième phase, basé sur le coefficient de réponse élastique des ponts isolés, une méthode de conception simplifiée d’amortisseur pour des ponts routiers réguliers isolés à la base a été présentée dans cette étude. En sélectionnant des objectifs pour la réduction du déplacement et la variation de l’effort tranchant, la rigidité et l'amortissement exigés d'un amortisseur hystérétique peuvent être déterminés. L’étude s’est poursuivie par une modélisation numérique d’un pont à deux portées pour vérifier l'efficacité de la méthode. Pour un modèle numérique d'un pont isolé typique, la méthode a été utilisée pour identifier des paramètres linéaires équivalents pour un certain déplacement et effort tranchant désigné. Par la suite, assumant un amortisseur de type hystérétique, les paramètres non linéaires de l’amortisseur ont été calculés et utilisés. La comparaison des résultats du modèle numérique sans amortisseur et avec l'amortisseur a démontré que la méthode proposée est suffisamment précise. Par la suite, un nouvel amortisseur hystérétique simple en acier a été conçu. Cinq spécimens ont été fabriqués de deux différents grades d’acier et ont été testés en combinaison avec un isolateur à l’échelle réelle dans le laboratoire de structures de l'Université de Sherbrooke. La procédure comprenait la caractérisation des spécimens par des tests cycliques en contrôle de déplacement et par la suite la réalisation d’essais par la méthode de sous-structuration dynamique en temps réel. Les résultats des essais ont été utilisés pour établir un modèle numérique du système qui a subi des analyses temporelles non linéaires sous plusieurs séismes. Le résultat des essais expérimentaux et numériques montrent une conformité acceptable avec la méthode simplifiée.

Extracellular neuroelectronic interfacing has important applications in the fields of neural prosthetics, biological computation and whole-cell biosensing for drug screening and toxin detection. While the field of neuroelectronic interfacing holds great promise, the recording of high-fidelity signals from extracellular devices has long suffered from the problem of low signal-to-noise ratios and changes in signal shapes due to the presence of highly dispersive dielectric medium in the neuron-microelectrode cleft. This has made it difficult to correlate the extracellularly recorded signals with the intracellular signals recorded using conventional patch-clamp electrophysiology. For bringing about an improvement in the signalto-noise ratio of the signals recorded on the extracellular microelectrodes and to explore strategies for engineering the neuron-electrode interface there exists a need to model, simulate and characterize the cell-sensor interface to better understand the mechanism of signal transduction across the interface. Efforts to date for modeling the neuron-electrode interface have primarily focused on the use of point or area contact linear equivalent circuit models for a description of the interface with an assumption of passive linearity for the dynamics of the interfacial medium in the cell-electrode cleft. In this dissertation, results are presented from a nonlinear dynamic characterization of the neuroelectronic junction based on Volterra-Wiener modeling which showed that the process of signal transduction at the interface may have nonlinear contributions from the interfacial medium. An optimization based study of linear equivalent circuit models for representing signals recorded at the neuron-electrode interface subsequently iv proved conclusively that the process of signal transduction across the interface is indeed nonlinear. Following this a theoretical framework for the extraction of the complex nonlinear material parameters of the interfacial medium like the dielectric permittivity, conductivity and diffusivity tensors based on dynamic nonlinear Volterra-Wiener modeling was developed. Within this framework, the use of Gaussian bandlimited white noise for nonlinear impedance spectroscopy was shown to offer considerable advantages over the use of sinusoidal inputs for nonlinear harmonic analysis currently employed in impedance characterization of nonlinear electrochemical systems. Signal transduction at the neuron-microelectrode interface is mediated by the interfacial medium confined to a thin cleft with thickness on the scale of 20-110 nm giving rise to Knudsen numbers (ratio of mean free path to characteristic system length) in the range of 0.015 and 0.003 for ionic electrodiffusion. At these Knudsen numbers, the continuum assumptions made in the use of Poisson-Nernst-Planck system of equations for modeling ionic electrodiffusion are not valid. Therefore, a lattice Boltzmann method (LBM) based multiphysics solver suitable for modeling ionic electrodiffusion at the mesoscale neuron-microelectrode interface was developed. Additionally, a molecular speed dependent relaxation time was proposed for use in the lattice Boltzmann equation. Such a relaxation time holds promise for enhancing the numerical stability of lattice Boltzmann algorithms as it helped recover a physically correct description of microscopic phenomena related to particle collisions governed by their local density on the lattice. Next, using this multiphysics solver simulations were carried out for the charge relaxation dynamics of an electrolytic nanocapacitor with the intention of ultimately employing it for a simulation of the capacitive coupling between the neuron and the v planar microelectrode on a microelectrode array (MEA). Simulations of the charge relaxation dynamics for a step potential applied at t = 0 to the capacitor electrodes were carried out for varying conditions of electric double layer (EDL) overlap, solvent viscosity, electrode spacing and ratio of cation to anion diffusivity. For a large EDL overlap, an anomalous plasma-like collective behavior of oscillating ions at a frequency much lower than the plasma frequency of the electrolyte was observed and as such it appears to be purely an effect of nanoscale confinement. Results from these simulations are then discussed in the context of the dynamics of the interfacial medium in the neuron-microelectrode cleft. In conclusion, a synergistic approach to engineering the neuron-microelectrode interface is outlined through a use of the nonlinear dynamic modeling, simulation and characterization tools developed as part of this dissertation research.