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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Nova Scotia Parents' Perceptions on the use of Smartphone Health Applications in Improving Family Nutrition and Physical Activity Habits

Andrien, Katherine 26 August 2013 (has links)
Busy families of Nova Scotia and similar populations find it challenging to make healthy nutrition and exercise choices due to time constraints (Chircop et al, under review; Jabs et al, 2007; Devine et al, 2006). Smartphone application technology can provide health behavior change interventions in a mobile and fast format (Breton, Bernard, Fuemmeler, Lorien & Abroms, 2011). Using focus groups, this research addressed parent’s perceptions on how smartphone application technology can support nutrition and physical activity habits within their family and what, if any, barriers exist in adopting this form of health behavior intervention. Findings revealed this population believes smartphone health applications can improve family nutrition and physical activity as long as barriers are minimized and requirements for adoption are met. Diffusion of Innovations theory was used to understand the adoption rate within the target population. Thoughts on future work efforts for related health behaviour interventions is discussed.
2

DIETARY MODULATION OF MYELOID DERIVED SUPPRESSOR CELL BIOLOGY IN PATHOPHYSIOLOGY AND PHYSIOLOGY

Ryan D Calvert (6554648) 15 May 2019 (has links)
T-cells are present in the immune system to fight against invaders. Once their job is done, suppressing their activity is an important step in maintaining a proper immune response. Myeloid derived suppressor cells (MDSCs) are immune cells that suppress T-cell activity. Currently, MDSCs are defined as a heterogeneous population of immature cells that are derived in the bone marrow and travel to the site of inflammation or cancer. Two major subtypes of MDSCs have been identified in mice and humans, monocyte-like MDSCs (M-MDSC) and granulocyte MDSCs (G-MDSC). G-MDSCs typically make up the majority of the total population of MDSCs but are less T-cell suppressive than M-MDSCs. One of the major problems in the study of MDSCs is that the current marker system for subtypes does not differentiate between precursor MDSCs (lacking suppressive ability) and functional MDSCs (those with suppressive ability). Therefore, using cancer models in mice, we investigated the development and potential to classify precursor MDSCs from functional MDSCs. While MDSCs have been highlighted as a target cell to inhibit in cancer, in other conditions, such as pregnancy, MDSCs have been shown to be beneficial in maintaining a normal pregnancy. Therefore, targeting the increase of MDSCs in abnormal pregnancy conditions like pre-eclampsia may act as a prevention or therapeutic strategy. Finally, it is known that many dietary components can act as modulators of immune cells. Specifically, the polyphenol like phytochemical, curcumin has been shown to act as an anti-inflammatory agent with the potential to modulate multiple immune cells. Therefore, we propose two different studies to investigate the potential of curcumin as either an inhibitor and/or promotor of MDSCs in a disease-specific context. Together the role of phytochemicals as immunomodulators of MDSCs is still very young, in part due to the complexity of phytochemicals themselves, but the studies cited here provide evidence that the field is ripe for additional questions to be asked.

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