No description available.

Thesis (M.S.)--University of Michigan, 1989.

Thesis (M.S.)--University of Michigan, 1989.

Thesis (Ph. D.)--University of Washington, 2007. / Vita. Includes bibliographical references (leaves 117-124).

No / The expression and potential role of platelet membrane CD154 and sCD154 in atherosclerosis was investigated in patients with peripheral arterial disease. This prospective observational study measured the expression of platelet-bound CD154 and soluble CD154 (sCD154) in 39 patients with critical limb ischaemia (CLI, n = 15), stable intermittent claudication (SIC, n = 12) and age-matched controls (AMC, n = 12). Basal and agonist-stimulated CD154, P-selectin expression and fibrinogen binding was measured by whole blood flow cytometry, while sCD154 was measured in paired plasma samples by ELISA. Basal expression of CD154 on the platelet surface was enhanced in both groups of patients with peripheral arterial disease. However, the critical limb ischaemics showed the highest level of basal expression 0.7 ± 0.3 [median ± IQR] and was significantly increased compared to both stable intermittent claudicants and age-matched controls (P < 0.001). On agonist stimulation with either ADP or thrombin critical limb ischaemics demonstrated greater platelet reactivity and propensity to express CD154 compared to age-matched controls (P < 0.05). Confirmation of the cellular expression of CD154 results was obtained by measuring sCD154 concentrations in autologous plasma samples. Here plasma levels of sCD154 in critical limb ischaemics were significantly greater than both stable intermittent claudicants and age-matched controls (P < 0.005).

Diss. (sammanfattning) Stockholm : Karolinska institutet, 2005. / Härtill 4 uppsatser.

Peripheral arterial occlusive disease (PAOD) is an ischemic disease characterized by narrowing of the peripheral arteries due to the accumulation of atherosclerotic plaque in the inner lining of the vessels, which disrupts blood flow to downstream tissues. Blood can be redirected into collateral vessels, natural bypasses around arterial occlusions, causing shear-induced outward remodeling of the vessels. The enlarged vessels facilitate transfer of increased blood flow to downstream tissues. The remodeling process, however, may impair vasodilation, which in turn may cause or contribute to intermittent claudication- transient pain brought on by locomotion. To stimulate the growth of collateral arteries, the femoral arteries of young, otherwise healthy mice were ligated distally to the profunda femoris, the stem to the gracilis collateral circuit. The diameter of the profunda femoris artery was measured at rest and following gracilis muscle contraction 7 and 28 days post-surgery using intravital microscopy. Enlarged resting diameter, consistent with collateral enlargement, and impaired vasodilation was observed at day 7, but not at day 28. To determine if impaired functional vasodilation is due to impaired endothelial- or smooth muscle-dependent responses during outward remodeling, cell-dependent vasodilators were applied to the hindlimb. Endothelial- and smooth muscle-dependent vasodilation was significantly impaired 7 days post-ligation, but not 28 days after. This data supports the hypothesis that smooth muscle dysfunction causes impaired functional vasodilation in the early stages of collateral enlargement.

Diss. (sammanfattning) Linköping : Linköpings universitet, 2005. / Härtill 6 uppsatser.

Les nombreux avantages du poisson zèbre ont été utilisés pour modéliser deux maladies héréditaires: la desminopathie et la maladie veino-occlusive pulmonaire (MVOP). La desminopathie est une myopathie myofibrillaire caractérisée par la présence d’agrégats. Deux modèles, de perte et de gain de fonction ont permis de montrer l’importance à la fois de la perte de desmine fonctionnelle et de la présence d’agrégats. Les phénotypes observés incluent en particulier des défauts biomécaniques de la contraction cardiaque et de la propagation calcique myocardique. Des approches thérapeutiques, réduisant la taille des agrégats, sont proposées. Après avoir validé l’utilisation du poisson-zèbre comme modèle d’étude de l’hypertension artérielle, en vérifiant l’implication de l’élasticité de la paroi artérielle dans la régulation du flux sanguin, des modèles de MVOP, une forme rare et sévère d’hypertension pulmonaire, ont été générés et étudiés. Ils confirment la spécificité veineuse de la MVOP. / The numerous advantages of zebrafish were used to study two hereditary diseases: desminopathy and pulmonary veno-occlusive disease (PVOD). Desminopathy is a myofibrillar myopathy characterized by the presence of granulofilamentous aggregates. Two models of loss and gain of function of desmin showed the implication of both loss of functional desmin and presence of desmin aggregates in desminopathy clinical manifestations. Phenotypes observed in these models include in particular a perturbation of the heart contraction biomechanics and of calcium propagation throughout the myocardium. Potential drugs, lowering the aggregate content, were proposed. After validating the use of zebrafish as a model of arterial hypertension, by verifying the implication of the elasticity of the aorta in blood flow regulation, we generated and characterized PVOD models. PVOD is a rare and severe form of pulmonary hypertension. The venous-specificity of the phenotypes observed in this pathology was confirmed.

Tang, Suk Yan Amy. / Thesis (M.Phil.)--Chinese University of Hong Kong, 2001. / Includes bibliographical references (leaves [207]-[227]). / Abstracts in English and Chinese. / ACKNOWLEDGEMENTS / ABSTRACTS / TABLE OF CONTENTS / "LIST OF APPENDIX, TABLES & FIGURES" / Chapter CHAPTER ONE --- INTRODUCTION --- p.1 / Chapter 1.1 --- Cerebrovascular disease --- p.1 / Chapter 1.1.1 --- Ischemic Stroke --- p.1 / Chapter 1.1.2 --- Hemorrhagic Stroke --- p.2 / Chapter 1.2 --- Laboratory diagnosis --- p.3 / Chapter 1.2.1 --- Transcranial Doppler ultrasonography --- p.4 / Chapter 1.2.1.1 --- Normal Brain --- p.4 / Chapter 1.2.1.2 --- Intracranial Large Artery Stenosis --- p.5 / Chapter 1.3 --- Asymptomatic Intracranial Stenosis --- p.6 / Chapter CHAPTER TWO --- LITERATURE REVIEW --- p.7 / Chapter 2.1 --- Global Stroke Facts --- p.7 / Chapter 2.2 --- Stroke Studies --- p.7 / Chapter 2.2.1 --- Risk profile of stroke --- p.7 / Chapter 2.2.2 --- Stroke epidemiological study --- p.8 / Chapter 2.2.2.1 --- Incidence --- p.8 / Chapter 2.2.2.2 --- Mortality --- p.10 / Chapter 2.2.2.3 --- Increased stroke rates with increased age --- p.12 / Chapter 2.2.2.4 --- Associated disease in stroke subjects --- p.12 / Chapter 2.2.3 --- Stroke risk factors --- p.13 / Chapter 2.3 --- Stroke Impact --- p.14 / Chapter 2.3.1 --- Stroke patients --- p.14 / Chapter 2.3.2 --- Medical burden --- p.15 / Chapter 2.3.3 --- Socioeconomic burden --- p.16 / Chapter 2.4 --- Stroke Prevention --- p.17 / Chapter 2.5 --- Stroke Facts in Hong Kong --- p.19 / Chapter 2.6 --- Stroke Facts in China --- p.21 / Chapter 2.7 --- Asymptomatic Intracranial Stenosis in Asian Subjects --- p.22 / Chapter 2.7.1 --- Asymptomatic individuals --- p.22 / Chapter 2.7.2 --- Intracranial occlusive disease --- p.23 / Chapter 2.8 --- Transcranial Doppler Sonography --- p.25 / Chapter CHAPTER THREE --- AIM & OBJECTIVES OF THE RESEARCH --- p.30 / Chapter 3.1 --- Aim of the research --- p.30 / Chapter 3.2 --- Objectives of this research --- p.30 / Chapter CHAPTER FOUR --- "CLINIC-BASED CROSS-SECTIONAL SCREENING IN AN URBAN CITY 226}0ؤ HONG KONG, THE PEOPLE'S REPUBLIC OF CHINA" --- p.31 / Chapter 4.1 --- Background & Purpose --- p.31 / Chapter 4.2 --- Methods --- p.34 / Chapter 4.2.1 --- Defining the population --- p.34 / Chapter 4.2.2 --- Procedures --- p.36 / Chapter 4.2.2.1 --- Standardized TCD Report Form --- p.39 / Chapter 4.2.2.2 --- Transcranial Doppler Screening --- p.39 / Chapter 4.2.2.3 --- Data collected --- p.40 / Chapter 4.2.3 --- Defining the Risk Factors --- p.43 / Chapter 4.3 --- Statistical Analyses --- p.45 / Chapter 4.3.1 --- Research Design --- p.46 / Chapter 4.3.2 --- Descriptive Summary --- p.46 / Chapter 4.3.2.1 --- Cross-tabulated between Gender --- p.46 / Chapter 4.3.2.2 --- Cross-tabulated between Normal & Abnormal MCA status --- p.47 / Chapter 4.3.3 --- Measures for Association --- p.48 / Chapter 4.3.3.1 --- Univariate analysis --- p.48 / Chapter 4.3.3.2 --- Multivariate analysis --- p.48 / Chapter 4.3.4 --- Modeling the Risks --- p.50 / Chapter 4.3.5 --- nfluence of the number of associated risk factors on the MCA status --- p.50 / Chapter 4.4 --- Result --- p.51 / Chapter 4.4.1 --- Baseline characteristics of all screened subjects by Gender --- p.51 / Chapter 4.4.1.1 --- Age by Gender --- p.53 / Chapter 4.4.1.2 --- "Medical History of HT, DM, Hyperlipidemia, IHD, Retinopathy and Albuminuria by Gender" --- p.55 / Chapter 4.4.1.3 --- Social habit in Smoking by Gender --- p.56 / Chapter 4.4.1.4 --- Body Mass Index and Waist-to-Hip Ratio by Gender --- p.57 / Chapter 4.4.2 --- Diseased Middle Cerebral Artery --- p.61 / Chapter 4.4.3 --- Characteristics between subjects with Normal TCD result and Abnormal TCD result in the MCA status --- p.62 / Chapter 4.4.3.1 --- Age --- p.64 / Chapter 4.4.3.2 --- Gender --- p.67 / Chapter 4.4.3.3 --- "Medical History of HT, DM, Hyperlipidemia, IHD, Retinopathy and Albuminuria" --- p.67 / Chapter 4.4.3.4 --- Social habit in cigarette smoking --- p.68 / Chapter 4.4.3.5 --- Body Mass Index and Waist-to-Hip Ratio --- p.71 / Chapter 4.4.3.6 --- "Other Measurements - on Blood Pressure, Fasting Plasma Glucose, HbAlc, Lipid profiles and Fibrinogen" --- p.79 / Chapter 4.4.4 --- Unadjusted Odds Ratio --- p.84 / Chapter 4.4.4.1 --- By contingency table method --- p.84 / Chapter 4.4.4.2 --- By logistic regression model --- p.86 / Chapter 4.4.5 --- Adjusted Odds Ratio --- p.92 / Chapter 4.4.5.1 --- Entering all explanatory variables: --- p.92 / Chapter 4.4.5.2 --- Using Forward and Backward Stepwise methods with the probability for entry of 0.05 and probability for removal of 0.10: --- p.95 / Chapter 4.4.5.3 --- Applying the Model-Building Strategy: --- p.100 / Chapter 4.4.6 --- Comparing the final fitted multiple logistic regression models made by the three approaches ： --- p.103 / Chapter 4.4.7 --- Probability and Odds derived from the logistic regression model --- p.110 / Chapter 4.4.8 --- Relationship between the diseased MCA and the number of significant risk indicators that the subjects associated with..… --- p.112 / Chapter 4.4.8.1 --- Logistic regression analysis on number of risk indicators associated with the MCA status --- p.115 / Chapter 4.5 --- Discussion --- p.118 / Chapter 4.5.1 --- Research Design --- p.118 / Chapter 4.5.1.1 --- Advantage --- p.118 / Chapter 4.5.1.2 --- Disadvantage --- p.118 / Chapter 4.5.2 --- Sampling --- p.119 / Chapter 4.5.3 --- Data collected and Outcome variable classified --- p.119 / Chapter 4.5.3.1 --- Medical Record - Patients Characteristics --- p.119 / Chapter 4.5.3.2 --- Transcranial Doppler - Middle Cerebral Artery status --- p.120 / Chapter 4.5.4 --- Statistical Analyses --- p.121 / Chapter 4.5.4.1 --- Odds Ratio --- p.121 / Chapter 4.5.4.2 --- Logistic Regression Model --- p.122 / Chapter 4.5.4.3 --- Sources of Error --- p.123 / Chapter 4.5.5 --- Result --- p.125 / Chapter 4.5.5.1 --- Prevalence --- p.125 / Chapter 4.5.5.2 --- Risk indicators --- p.126 / Chapter CHAPTER FIVE --- "POPULATION-BASED CROSS-SECTIONAL SURVEY IN A RURAL VILLAGE OF HENAN, PEOPLE'S REPUBLIC OF CHINA" --- p.134 / Chapter 5.1 --- Background & Purpose --- p.134 / Chapter 5.2 --- Methods --- p.135 / Chapter 5.2.1 --- Defining the Population --- p.135 / Chapter 5.2.2 --- Procedures --- p.135 / Chapter 5.2.2.1 --- Standardized Screening Form --- p.136 / Chapter 5.2.2.2 --- Transcranial Doppler Examination --- p.137 / Chapter 5.2.3 --- Defining the Risk Factors --- p.137 / Chapter 5.3 --- Statistical Analyses --- p.140 / Chapter 5.3.1 --- Research Design --- p.141 / Chapter 5.3.2 --- Descriptive Summary --- p.141 / Chapter 5.3.2.1 --- Cross-tabulated between Gender --- p.141 / Chapter 5.3.2.2 --- Cross-tabulated between With & Without intracranial large artery stenosis --- p.142 / Chapter 5.3.3 --- Measures for Association --- p.143 / Chapter 5.3.3.1 --- Univariate analysis --- p.143 / Chapter 5.3.3.2 --- Multivariate analysis --- p.143 / Chapter 5.3.4 --- Modeling the Risks --- p.144 / Chapter 5.3.5 --- Influence of the number of associated risk factors on the prevalence of intracranial large artery stenosis --- p.144 / Chapter 5.4 --- Result --- p.145 / Chapter 5.4.1 --- Baseline characteristics of all examined villagers by Gender --- p.145 / Chapter 5.4.1.1 --- Age by Gender --- p.147 / Chapter 5.4.1.2 --- "Medical History of HT, DM and Heart disease by Gender" --- p.149 / Chapter 5.4.1.3 --- Social habit in Cigarette smoking and Alcoholic drinking by Gender --- p.149 / Chapter 5.4.1.4 --- "Family History of HT, DM, Stroke and Heart disease by Gender" --- p.149 / Chapter 5.4.1.5 --- Body Mass Index and Waist-to-Hip Ratio by Gender --- p.150 / Chapter 5.4.2 --- Distribution of the Diseased intracranial artery --- p.154 / Chapter 5.4.3 --- Characteristics between subjects with and without intracranial large artery stenosis --- p.155 / Chapter 5.4.3.1 --- Age --- p.157 / Chapter 5.4.3.2 --- Gender --- p.158 / Chapter 5.4.3.3 --- "Medical History of HT, DM and Heart disease" --- p.158 / Chapter 5.4.3.4 --- Social habit in cigarette smoking and alcohol drinking --- p.158 / Chapter 5.4.3.5 --- "Family History of HT, DM, Stroke and Heart Disease" --- p.159 / Chapter 5.4.3.6 --- Body Mass Index and Waist-to-Hip Ratio --- p.160 / Chapter 5.4.3.7 --- Other Measurements - on BP and Urine Glucose --- p.163 / Chapter 5.4.4 --- Unadjusted Odds Ratio --- p.165 / Chapter 5.4.4.1 --- By contingency table method --- p.165 / Chapter 5.4.4.2 --- By logistic regression model --- p.166 / Chapter 5.4.5 --- Adjusted Odds Ratio --- p.172 / Chapter 5.4.5.1 --- Entering all explanatory variables: --- p.172 / Chapter 5.4.5.2 --- Using the Stepwise methods available with the probability for entry is 0.05 and 0.10 for removal: --- p.175 / Chapter 5.4.5.3 --- Applying the Model-Building Strategy: --- p.180 / Chapter 5.4.6 --- Comparing the final multiple logistic regression models by the three approaches： --- p.182 / Chapter 5.4.7 --- Probability and Odds derived from the logistic regression model --- p.189 / Chapter 5.4.8 --- Relationship between the transcranial Doppler result on Intracranial large artery and the number of significant risk indicators that the subjects associated with --- p.190 / Chapter 5.4.8.1 --- Logistic Regression Model --- p.192 / Chapter 5.5 --- Discussion --- p.196 / Chapter 5.5.1 --- Research Design --- p.196 / Chapter 5.5.1.1 --- Advantage --- p.196 / Chapter 5.5.1.2 --- Disadvantage --- p.196 / Chapter 5.5.2 --- Sampling --- p.197 / Chapter 5.5.3 --- Data collected and the Outcome variable classified --- p.197 / Chapter 5.5.3.1 --- Self-Reported - Subjects Characteristics --- p.197 / Chapter 5.5.3.2 --- Transcranial Doppler - Intracranial Large Artery status --- p.198 / Chapter 5.5.4 --- Statistical Methods --- p.199 / Chapter 5.5.4.1 --- Odds Ratio --- p.199 / Chapter 5.5.4.2 --- Logistic Regression --- p.199 / Chapter 5.5.4.3 --- Sources of Error --- p.199 / Chapter 5.5.5 --- Result --- p.200 / Chapter 5.5.5.1 --- Prevalence --- p.200 / Chapter 5.5.5.2 --- Risk Indicators --- p.201 / Chapter CHAPTER SIX --- CONCLUSION --- p.204 / Chapter 6.1 --- The Clinic-based study of diseased middle cerebral artery among asymptomatic hong kong chinese --- p.204 / Chapter 6.2 --- The Population-base study of intracranial large artery stenosis among mid-aged & above chinese in rural china --- p.205 / REFERENCES / APPENDIX / Appendix I Neuroimaging - Transcranial Doppler Ultrasonography / Appendix II Statistical Methods / "Appendix III (a) Standardized TCD report form used in PWH, Hong Kong (b) Standardized Screening Form used In Yuzhou, China" / Appendix IV The ICD 9th Revision - Disease of the Circulatory System / "Appendix V Prospective Hospital-Based study in Asia, AASAP (a) Standardized Data Collection From used in AASAP" / Appendix VI Contributed in published papers