Background: Prostate cancer is the most common form of cancer among men in Sweden. Many people that are diagnosed or going through treatment for the disease experiences negative side effects. It´s not uncommon with side effects that give problems with sexual health. Aim: The objective of the study is to investigate the connection between problems with worry/anxiety/depression and sexual activity and perceived sexual function for men with prostate cancer. Method: This study was conducted as a quantitative cross-sectional study, as part of a larger ongoing study, with data collected from members in the SPCF (Svenska Prostatacancer Förbundet) with help of questionnaires. Data collected from 3165 men who regardless of treatment and age were analyzed and studied by division into two groups. Results: The results showed that men who has problems with any form of worry/anxiety/depression are less sexually active than men who not had problems. It also shows that men with less sexual activity think themselves as less satisfied than men with no problems. Conclusion: The study shows that there is a connection between worry/anxiety/depression and sexual activity and perceived sexual function on men with prostate cancer. Various finds have been discovered in the study and knowledge gaps have been illustrated. Nurses can use the schedule as a help whit their work about the sexual health.