Made available in DSpace on 2014-06-11T19:27:53Z (GMT). No. of bitstreams: 0 Previous issue date: 2007-03-02Bitstream added on 2014-06-13T19:15:31Z : No. of bitstreams: 1 dib_lps_me_arafo.pdf: 916738 bytes, checksum: bccf4c5a5b8970b365f2cd0e715dff45 (MD5) / Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) / Este estudo cefalométrico foi desenvolvido com o propósito de avaliar as alterações dentárias e esqueléticas naturais e induzidas pelo uso do aparelho de Herbst. O grupo experimental foi constituído por 15 indivíduos pré-pubertários, leucodermas, com idade média de 9,4 anos (+ ou - 06 meses), de ambos os gêneros, com má oclusão Classe II Divisão 1ª com deficiência mandibular. Foi utilizado para comparação um grupo controle de 15 indivíduos, leucodermas, com má oclusão Classe II Divisão 1ª, não tratados ortodonticamente, pareados quanto às idades óssea e cronológica do grupo experimental, derivados do Burlington Growth Centre, Departamento de Ortodontia da Faculdade de Odontologia, Universidade de Toronto, Canadá. Foram realizadas radiografias em norma lateral iniciais e após 7 meses de tratamento no grupo experimental e no grupo controle as radiografias foram tomadas aos 9 e 10 anos de idade. A análise estatística foi realizada por meio do teste t de Student, com nível de significância de 5%. De acordo com os dados obtidos, verificamos que o uso do aparelho de Herbst resultou numa restrição significativa do crescimento maxilar, enquanto que o efeito do crescimento natural havia sido de aumentar o comprimento da maxila; o crescimento mandibular foi estimulado em ambos os grupos, porém mais intenso no grupo tratado; houve aumento das alturas faciais anterior e posterior no grupo experimental, ao passo que no grupo controle a altura facial posterior não foi alterada; em relação à convexidade facial e a relação maxilo-mandibular houve uma alteração positiva no grupo tratado, enquanto no grupo não tratado elas se mantiveram estáveis; e, o plano mandibular não sofreu alteração em ambos os grupos. As alterações dentárias caracterizaram-se no grupo tratado pela verticalização dos incisivos superiores, distalização dos molares... / This cephalometric study was developed in order to evaluate natural dental and skeletal alterations as well as those induced by the use of Herbst's appliance. The experimental group consisted of 15 pre-pubertal individuals, white children, with mean age of 9.4 years (+ or - 06 months), both male and female, presenting Class II, 1st Division malocclusion and mandibular deficiency. A control group of 15 white children with Class II, 1st Division malocclusion, who were not treated orthodontically, was used for comparison, paired considering bone and chronological ages of the experimental group, originally from Burlington Growth Centre, Orthodontics Department of the University of Toronto Dental School, Canada. Initial and 7-month treatment follow-up radiographs were obtained in lateral take for the experimental group, and for the control group the radiographs were taken at 9 and 10 years of age. Statistical analysis was carried out with Student's test, at significance level of 5%. According to the data obtained, it was verified that the use of Herbst's appliance resulted in a significant restriction of the maxillary growth, while the effect of natural growth had been to increase maxilla length; mandibular growth was stimulated in both groups, however, it was more intense in the group treated; there was an increase in the anterior and posterior facial heights of the experimental group, whereas in the control group the posterior facial height was not altered; considering facial convexity and the maxilla-mandible relationship, there was a positive alteration in the group treated, while in the non-treated group they were kept stable; and, the mandibular plane suffered no alteration in any of the groups. In the treated group, dental alterations were characterized by the verticalization of the maxillary incisors, distal tipping of the maxillary molars, buccal tipping of the mandibular... (Complete abstract, click electronic access below)

Orientador: Dirceu Barnabé Raveli / Banca: Francisco Antonio Bertoz / Banca: Ary dos Santos-Pinto / Banca: / Resumo: Este estudo prospectivo sobre o aparelho Herbst splint metálico analisou as alterações esqueléticas e dentárias que contribuíram para a correção da Classe II divisão 1 em indivíduos tratados após o surto de crescimento pubertário. Além disso, foram avaliadas as alterações com relação à forma de avanço, ou seja, avanço único ou seqüencial. A amostra foi composta por 12 indivíduos, 07 do gênero feminino e 05 do gênero masculino, com idade média inicial de 15,51 anos. Para avaliação utilizou-se radiografias cefalométricas laterais iniciais e finais obtidas após um período médio de tratamento de 8,21 meses. A análise estatística foi realizada por meio do teste t de Student, com nível de significância de 5%. Para avaliação das alterações entre os dois tipos de avanço, o teste t de Student foi precedido pelo teste de Levene para a igualdade das variâncias. Os resultados mostram que não houve alteração significante no deslocamento da maxila, mas ocorreu crescimento mandibular e posicionamento mais anterior da mandíbula, aumento das alturas faciais anterior e posterior sem alterar o padrão facial e ausência de abertura do plano mandibular. As alterações dentárias caracterizam-se principalmente pela vestibularização dos incisivos inferiores, retroinclinação e extrusão dos incisivos superiores. Os molares superiores e inferiores mantiveram sua posição dentro da base óssea. Todos os indivíduos obtiveram relações oclusais Classe I ou Classe I sobrecorrigida. Observou-se que o tratamento com avanço único apresentou vestibularização, significantemente maior, dos incisivos inferiores que o tratamento realizado com avanço seqüencial, contudo não se observou diferença significante nas outras medidas. Concluiu-se que o aparelho de Herbst foi eficaz no tratamento da má oclusão Classe II em todos os indivíduos após o surto...(Resumo completo, clicar acesso eletrônico abaixo) / Abstract: The present prospective study on Herbst cast splint assessed skeletal and dental alterations that contributed towards Class II correction in individuals treated after pubertal after growth spurt. In addition, the alterations were evaluated with regard to the form of advancement, that is, single or sequential advancement. The sample comprised 12 individuals, 07 female and 05 male, with initial mean age of 15,51 years. Initial and final lateral cephalometric teleradiographs obtained after a mean treatment period of 8,21 months were used to perform the evaluation. Statistical analysis was carried out using Student's t test, with significance level of 5%. In order to evaluate the alterations between the two types of advancement, Student's t test was preceded by Levene's test to equal the variances. Results evidence that there was no significant alteration over the maxilla, there was stimulation of mandibular growth and more anterior positioning of the mandibula, increase in anterior and posterior facial heights with no alteration of the facial pattern, and absence of mandibular plane opening. Dental alterations were characterized mainly by the buccal tipping of mandibular incisors, as well as retroclination and extrusion of maxillary incisors. However, maxillary and mandibular molars maintained their position within the osseous base. All the individuals have obtained Class I or overcorrected Class I occlusal relationships. The treatment with single advancement was found to show significantly greater buccal tipping of the mandibular incisors than the treatment performed with sequential advancement; nevertheless, the other measurements have not shown significant difference. It was concluded that Herbst cast splint appliance was effective in treating Class II malocclusion in all the individuals after after growth spurt. Furthermore, the treatment with sequential advancement...(Complete abstract click electronic access below) / Mestre

Orientador: Dirceu Barnabé Raveli / Banca: Gladys Cristina Dominguez Rodriguez / Banca: Ary dos Santos-Pinto / Resumo: Este estudo cefalométrico foi desenvolvido com o propósito de avaliar as alterações dentárias e esqueléticas naturais e induzidas pelo uso do aparelho de Herbst. O grupo experimental foi constituído por 15 indivíduos pré-pubertários, leucodermas, com idade média de 9,4 anos (+ ou - 06 meses), de ambos os gêneros, com má oclusão Classe II Divisão 1ª com deficiência mandibular. Foi utilizado para comparação um grupo controle de 15 indivíduos, leucodermas, com má oclusão Classe II Divisão 1ª, não tratados ortodonticamente, pareados quanto às idades óssea e cronológica do grupo experimental, derivados do Burlington Growth Centre, Departamento de Ortodontia da Faculdade de Odontologia, Universidade de Toronto, Canadá. Foram realizadas radiografias em norma lateral iniciais e após 7 meses de tratamento no grupo experimental e no grupo controle as radiografias foram tomadas aos 9 e 10 anos de idade. A análise estatística foi realizada por meio do teste t de Student, com nível de significância de 5%. De acordo com os dados obtidos, verificamos que o uso do aparelho de Herbst resultou numa restrição significativa do crescimento maxilar, enquanto que o efeito do crescimento natural havia sido de aumentar o comprimento da maxila; o crescimento mandibular foi estimulado em ambos os grupos, porém mais intenso no grupo tratado; houve aumento das alturas faciais anterior e posterior no grupo experimental, ao passo que no grupo controle a altura facial posterior não foi alterada; em relação à convexidade facial e a relação maxilo-mandibular houve uma alteração positiva no grupo tratado, enquanto no grupo não tratado elas se mantiveram estáveis; e, o plano mandibular não sofreu alteração em ambos os grupos. As alterações dentárias caracterizaram-se no grupo tratado pela verticalização dos incisivos superiores, distalização dos molares... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: This cephalometric study was developed in order to evaluate natural dental and skeletal alterations as well as those induced by the use of Herbst's appliance. The experimental group consisted of 15 pre-pubertal individuals, white children, with mean age of 9.4 years (+ or - 06 months), both male and female, presenting Class II, 1st Division malocclusion and mandibular deficiency. A control group of 15 white children with Class II, 1st Division malocclusion, who were not treated orthodontically, was used for comparison, paired considering bone and chronological ages of the experimental group, originally from Burlington Growth Centre, Orthodontics Department of the University of Toronto Dental School, Canada. Initial and 7-month treatment follow-up radiographs were obtained in lateral take for the experimental group, and for the control group the radiographs were taken at 9 and 10 years of age. Statistical analysis was carried out with Student's test, at significance level of 5%. According to the data obtained, it was verified that the use of Herbst's appliance resulted in a significant restriction of the maxillary growth, while the effect of natural growth had been to increase maxilla length; mandibular growth was stimulated in both groups, however, it was more intense in the group treated; there was an increase in the anterior and posterior facial heights of the experimental group, whereas in the control group the posterior facial height was not altered; considering facial convexity and the maxilla-mandible relationship, there was a positive alteration in the group treated, while in the non-treated group they were kept stable; and, the mandibular plane suffered no alteration in any of the groups. In the treated group, dental alterations were characterized by the verticalization of the maxillary incisors, distal tipping of the maxillary molars, buccal tipping of the mandibular... (Complete abstract, click electronic access below) / Mestre

Dissertation submitted in compliance with the requirement for a Master's Degree in Technology: Chiropractic, Technikon Natal, 1996. / The purpose of this study was to compare the effects of McMannis traction and Intermittent traction, both m conjunction with chiropractic manipulation in the treatment of chronic i.e. longer than four weeks, mechanical lower back pain. It was hypothesised by the author that McMannis traction would be the traction treatment of choice, as it enables the joints of the lumbar vertebrae to be moved through their normal anatomical range of motion while being traeticned axially. In addition this type of traction is more specific and allows the therapist to determine the amount of traction that is being applied to the patient because it is being applied manually. Intermittent traction on the other hand is a motorised non-specific traction and affects several joints at one time (Saunders 1979). / M

As micobacterioses são doenças causadas por micobactérias não tuberculosas pertencentes ao gênero Mycobacterium. As infecções por micobactéria de crescimento rápido (MCR) estão fortemente relacionadas às falhas nos processos de limpeza, desinfecção e esterilização de produtos médicos. Objetiva-se, analisar a ocorrência de infecções de sítio cirúrgico, por MCR, em pacientes submetidos a procedimentos ortopédicos, por meio de revisão integrativa; caracterizar as infecções de sítio cirúrgico (ISC) por MCR; verificar a presença de fatores que possam explicar as infecções de sítio cirúrgico por MCR. Como método utilizou-se a revisão integrativa, a qual contém as seguintes etapas: elaboração da questão da pesquisa; estabelecimento de critérios de inclusão e exclusão; definição das informações a serem extraídas do estudo; avaliação dos estudos incluídos; interpretação dos resultados e apresentação da revisão. No resultado foram encontrados 21 artigos, a maioria publicada no idioma inglês, e dois em francês, variando quanto ao continente e país de origem de edição. O tempo entre a cirurgia e o início dos sintomas foi mencionado para os 34 (100%) pacientes, mas a análise foi feita para 33 pacientes, pois se considerou apenas o primeiro episódio de infecção por MCR. O tempo médio para o diagnóstico da ISC foi de 653,6 dias (93 semanas), desvio padrão ±1.343 dias (192 semanas), mediana de 80 dias (11,4 semanas) e moda de 90 dias (três meses). Quanto aos sinais e sintomas relatados pelos pacientes, os mais prevalentes foram: dor (61,8%), secreção (50,0%), edema (41,2%), febre (41,2%), eritema (26,5%), fístula (20,6%), calor (14,7%), tremor (5,9%), abscesso (5,9%) e hematoma (3,0%). Em relação às intervenções cirúrgicas efetuadas nos pacientes, após o diagnóstico de ISC, a mais frequente foi a antibioticoterapia (100%), remoção de prótese total (50,0%), drenagem (41,2%), debridamento cirúrgico (41,2%), irrigação (23,5%), revisão cirúrgica (17,6%) troca da prótese total (8,8%), remoção de componentes da prótese (8,8%) e reimplante da prótese (2,9%). A identificação do(s) agente(s) etiológico(s) da(s) ISCs não seguiu uma metodologia de rotina, o que pode influenciar na confiabilidade do resultado, principalmente quanto à espécie do agente etiológico. Quanto à espécie de MCR isoladas dos sítios de infecção constatamos que M.fortuitum foi a mais prevalente; tendo sido isolados também M.chelonae, M.abscessus, M.goodii, M.smegmatis, M.farcinogenes e M.wolinskyi. Em relação às fontes investigadas, tem-se: provavelmente de origem iatrogênica, hábito do médico residente de ortopedia, presente nas cirurgias, de utilizar a hidromassagem antes de operar; componentes líquidos ou pó do cimento metilmetacrilato ou a prótese metálica; injeções de cortisona por sinovite crônica, durante cinco anos, antes da cirurgia; sistema de ar condicionado ou a solução de imersão para enxágue da prótese; sabão na água, onde foi realizada a imersão do pé (recomendação do podólogo); parafuso bioabsorvível utilizado na cirurgia; injeções intra-articulares de dexametasona; no entanto, nenhuma delas pode ser confirmada. Quando feito o teste de senbilidade observou-se que as cepas apresentavam em torno de 80% de sensibilidade à amicacina, claritromicina e ciprofloxacina. / The mycobacteriosis is a disease caused by nontuberculous mycobacteria belonged to the Mycobacterium genus. Infections due to rapidly growing mycobacteria (RGM) are strongly related to failures in the processes of cleaning, disinfection and sterilization of medical products. The objective is to analyze the occurrence of surgical site infections by RGM in patients undergoing orthopedic procedures through integrative review; to characterize the surgical site infections (SSI) by RGM; and to verify the presence of factors that may explain the surgical site infections by RGM. The method was the integrative review, which includes the following steps: elaboration of the research question; establishment of inclusion and exclusion criteria; definition of information to be extracted from the study; assessment of the included studies; interpretation of results; and presentation of the review. 21 articles were found, mostly published in English and two in French, varying considering the continent and country of the origin of the article. The time between surgery and onset of symptoms was reported by 34 (100%) patients, but the analysis was performed for 33 patients because it was considered only the first episode of infection by RGM. The average time to diagnosis of SSI was 653.6 days (93 weeks), standard deviation ± 1343 days (192 weeks), median of 80 days (11.4 weeks) and mode of 90 days (three months). The most prevalent signs and symptoms reported by patients were: pain (61.8%), secretion (50.0%), edema (41.2%), fever (41.2%), erythema (26.5%), fistula (20.6%), heat (14.7%), tremor (5.9%), abscess (5.9%) and hematoma (3.0%). Regarding surgical interventions performed in patients after diagnosis of SSI, the most frequent was antibiotic therapy (100%), removal of dentures (50.0%), drainage (41.2%), surgical debridement (41.2%), irrigation (23.5%), surgical revision (17.6%), replacement of dentures (8.8%), removal of the prosthetic components (8.8%), and reimplantation of the prosthesis (2.9%). The identification of etiological agent(s) of SSI did not follow a routine methodology, which can influence the reliability of the results, especially regarding the kind of etiologic agent. Related to the kind of isolated RGM of the infection sites, it was found that M.fortuitum was the most prevalent; being also isolated the M.chelonae, M.abscessus, M.goodii, M.smegmatis, M.farcinogenes and M.wolinskyi. Regarding the sources investigated: probably from iatrogenic origin, it is habits of residents in orthopedics during surgeries to use hydromassage before operating; liquid components or cement powder of methylmethacrylate or metal prosthesis; cortisone injections for chronic synovitis during 5 years before surgery; air conditioning system or soaking solution to rinse the denture; soap in the water, where it was accomplished the immersion foot (podiatrist\'s recommendation); bioabsorbable screws used in surgery; intraarticular injections of dexamethasone; however, none of them can be confirmed. When the sensitivity test was done, it was observed that the strains had approximately 80% of sensitivity to amikacin, clarithromycin, ciprofloxacin. Quando feito o teste de senbilidade observou-se que as cepas apresentavam em torno de 80% de sensibilidade à amicacina, claritromicina e ciprofloxacina.

Orientador: Rubens Caram Junior / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Mecânica / Made available in DSpace on 2018-08-26T06:50:38Z (GMT). No. of bitstreams: 1 Moraes_PauloEduardoLeite_M.pdf: 3749651 bytes, checksum: 89146f069c1475908f7a217f78acae9a (MD5) Previous issue date: 2013 / Resumo: O uso de ligas de titânio do tipo ß na fabricação de dispositivos ortopédicos tem aumentado continuamente nos últimos anos. Dentre as ligas do tipo ß promissoras como biomaterial destacam as ligas Ti-Nb. Nesse sistema, a precipitação indesejada da fase 'ômega' é comum e uma maneira de evitá-la é com a adição de Sn. Assim, este trabalho teve como objetivo examinar o processo de fundição de ligas Ti-30Nb (% em peso) com adições de 2, 4, 6, 8 e 10 % em peso de Sn. O trabalho foi elaborado a partir da preparação das amostras em forno a arco voltáico, seguido de conformação por processo de fundição por centrifugação e caracterização química, microestrutural e mecânica. Os resultados obtidos permitem concluir que amostras com geometrias medianamente complexas podem ser obtidas pelo processo de fundição por centrifugação. O uso de molde de cobre evita qualquer reação entre o fundido e as paredes do molde, bem como resulta em ótimo acabamento superficial. A solidificação das ligas Ti-Nb-Sn em molde de cobre resultou em microestrutura com caráter dendrítico acentuado. Observou-se que enquanto o Sn é segregado para regiões interdendríticas e o Nb concentra-se nos ramos dendríticos. No caso do processamento da Liga Ti-30Nb, a elevada taxa de resfriamento imposta pela solidificação em molde de cobre produz microestrutura formada pela martensita ortorrômbica (a"), pela fase ß e pela fase 'ômega'. À medida que o Sn foi adicionado à liga Ti-30Nb, observou-se a supressão da fase 'ômega' e também, a diminuição da fração volumétrica da fase martensítica. A análise por difração de raios-X também permitiu examinar o efeito do Sn nos parâmetros de rede da fase ß. Ensaios de dureza, de medidas de módulo de elasticidade e de ensaios de compressão mostraram que a adição de Sn resulta em comportamento mecânico que é coerente com a variação do parâmetro de rede da fase ß. / Abstract: The use of ß-type titanium alloys in the manufacture of orthopedic devices has increased steadily in recent years. Among the promising ß-type alloys to be applied as biomaterial are the Ti-Nb alloys. In the Ti-Nb system, the unwanted precipitation of 'ômega' phase is common and a way to avoid it is with the addition of Sn. Thus, this study aimed to examine the casting process of Ti-30Nb alloy (wt.%) with additions of 2, 4, 6, 8 and 10 wt% Sn. This work was carried out by preparing samples in arc furnace, forming by using centrifuge casting process and chemical, microstructural and mechanical characterization. The results obtained allowed concluding that samples with moderately complex geometries can be obtained by centrifuge casting process. The use of copper mold prevents any reaction between the melt and the mold walls, and results in excellent surface finishing. The solidification of Ti-Nb-Sn alloys in copper mold resulted in microstructure with pronounced dendritic character. It was observed that while the Sn is segregated to interdendritic regions, the Nb is concentrated in the dendritic branches. In the case of the Ti-30Nb alloy processing, the high cooling rate imposed by cast in copper mold produced a microstructure formed by orthorhombic martensite, ß phase and 'ômega' phase. As Sn is added to the Ti-30Nb alloy, it was observed the 'ômega' phase suppression as well as the decrease of the volume fraction of martensitic phase. X-ray diffraction analyses also made possible to examine the effect of Sn addition on the ß phase lattice parameters. Hardness tests, measurements of elastic modulus and compression tests showed that the addition of Sn results in mechanical behavior that is consistent with the variation of the ß phase lattice parameters. / Mestrado / Materiais e Processos de Fabricação / Mestre em Engenharia Mecânica

M.Tech. (Chiropractic) / Purpose: The purpose of this randomised comparative study was to establish the effects which these modalities had on pain perception and range of motion in patients with acute cervical facet syndrome. This was done by comparing manual cervical spine traction alone; to cervical spine adjustments alone to manual cervical spine traction applied post cervical spine adjustments. Method: A total of 30 participants were recruited for this study by placing advertisements in and around the University of Johannesburg, Doornfontein Campus. Participants had to meet the requirements of the inclusion criteria and were excluded if they were found to be unfit for this particular study. The 30 participants were asked to draw a number out of a bag which therefor randomly divided them into three groups of 10 participants each. Procedure: Participants in group A received manual cervical traction alone as their treatment. Participants in group B received cervical spine adjustments alone as their treatment. Finally, participants in group C were treated by performing manual cervical spine traction after the cervical spine adjustment. Each participant was treated a total of six times over a two week period. Measurements were taken on the first, fourth and a seventh consultation. Results: Regarding the Subjective readings, there was an improvement with regards to the Numerical Pain Rating Scale values for all three groups, but the combination group of manual cervical spine traction performed post cervical spine adjustment, showed the greatest improvement over the trial period on intra-group analysis. No statistical significant changes were found on inter group analysis. There was an improvement in Neck Pain Disability Index values for all three groups, but the cervical spine adjustment group showed the greatest improvement over the trial period on intra-group analysis. No statistical significant changes were found on inter group analysis. Regarding the Objective readings, there was an improvement in pressure algometer readings for all three groups, but the cervical spine adjustment group showed the greatest improvement over the trial period on intra-group analysis. No statistical significant changes were found on inter group analysis. There was an improvement in Cervical Range of Motion readings for all three groups, but the combination group of manual cervical spine traction performed post cervical spine adjustment showed the greatest improvement for flexion, extension and bilateral rotation on intra-group analysis. However, for bilateral lateral flexion, the cervical spine adjustment group showed the greatest improvement on intra group analysis. No statistical significant changes were found on inter group analysis. Conclusion: There were clinically significant improvements within each of the three groups on intra group analysis but no clinically significant differences were found on inter group analysis. Therefore, none of the groups could be singled out as being the best treatment approach for acute cervical facet syndrome. With regards to the Chiropractic profession the outcome of this study therefore suggests, that the chiropractic adjustment alone is sufficient in treatment of acute cervical facet syndrome as none of the groups proved to be superior.

Osteomyelitis or bone infections remain very difficult to treat despite advances in treatment regimens and surgical technics. The bone microenvironment and compromised vasculature in addition to infected prosthesis and implants that were put in the bone during prior surgery impedes the antibiotic partition into the bone from systemic therapy in many cases. Treatment often includes surgical debridement of the infected bone and surrounding tissue, removal of implants, systemic antibiotic therapy accompanied with antibiotic containing bone void filler, in most cases polymethylmethacylate (PMMA) based bone cement. Unfortunately, PMMA has many associated problems, including non-biodegradability, inconsistent antibiotic release, and a surface susceptible to bacterial biofilm growth, ultimately necessitating removal and causing recurrent infections. Thus, recent studies have focused on designing novel bone void filling materials to deliver antibiotics and to support bone regeneration. There are two parts to designing a successful bone void filling device/material:(1) local release antibiotic for infection treatment and (2) development of a bone graft substitute to support bone regrowth. In this study, antibiotic releasing bone void filler (ABVF) putty formulations have been designed and tested. Different formulations were examined in this dissertation to describe the three components of the putty formulation - polymer, drug, and substrate. In the first formulation, different custom-made polymers were used to control drug release; Pro Osteon, a hydroxyapatite (HA) and calcium carbonate based bone graft substitute was used to provide support for bone growth. Finally, vancomycin was used as the antibiotic as it is clinically used to treat Staphylococcus aureus, the primary cause of osteomyelitis. In second formulation, commercially available and clinically used polymers, poly(lactic-co-glycolic acid) (PLGA), polycaprolactone (PCL) and, polyethylene glycol (PEG), were used to make the ABVF putty along with Pro Osteon and vancomycin. In the subsequent formulations, delivering combination antibiotics - vancomycin and rifampicin - to treat biofilm infections and, using bioglass (BG) as the substrate for faster bone regrowth were explored; PLGA, PCL and PEG constituted the polymer matrix. The ABVF putty formulations were customizable in terms of three primary components: polymers, bone graft substitutes, antibiotics. Ultimately, these were successful in curing infection and providing bone growth support.

No description available.

No description available.