Sammanfattning   Syfte och frågeställningar Syftet med denna studie var att sammanställa kvalitet på och resultat av studier som undersökt om långdistanslöpning ger artros i höft-, knä- eller fotleder. Finns det vetenskaplig evidens för att långdistanslöpning ger artros i höft-, knä- eller fotleder? Vilka styrkor och svagheter har de studier som försökt utröna om samband finns mellan långdistanslöpning och artros i höft-, knä- eller fotleder?   Metod Sökning av litteratur utfördes i PubMed, CINAHL, Cochrane Library och PEDro. Detta resulterade i att tio artiklar inkluderades för närmare granskning och sammanställning. Utifrån artiklarnas sammantagna bevisvärde poängsattes och graderades artiklarna efter evidensnivå enligt Statens Beredning för medicinsk Utvärderings (SBU) granskningsmallar för kohortstudier med kontrollgrupper.   Resultat Endast en av tio studier visar ett positivt samband mellan långdistanslöpning och artros i höft-, knä- eller fotleder, i detta fall höftledsartros. Studierna har ingen tydlig och gemensam definition över vad långdistanslöpning är. De granskade studierna använder sig av olika mätmetoder för att bedöma leddegenerationen, både av självrapportering och av olika diagnostiska kriterier för artros. Alla studier har inslag av selektionsbias.   Slutsats En indikation på att det inte finns ett vetenskapligt stöd för att långdistanslöpning ger höft-, knä- eller fotledsartros hos människor. Studierna har brister i hantering av confounders och selektionsbias och bedöms vara av låg eller medelhög kvalitet. / Abstract   Aim The purpose of this study was to compile the quality and results of studies that examined if long-distance running gives osteoarthritis of the hip, knee or ankle joints. Is there scientific evidence that long-distance running gives osteoarthritis of the hip, knee or ankle? What strengths and weaknesses of the studies attempted to determine if the link between long-distance running and osteoarthritis of the hip, knee or ankle joints.   Method Search of the literature was performed in PubMed, CINAHL, Cochrane Library, and PEDro. This resulted in ten articles that were included for further review and compilation. Based on the articles combined probative value was scored and graded articles for level of evidence according to the National Council on Technology Evaluation (SBU) examination templates for cohort studies with control groups.   Results Only one of the ten studies showed a positive association between long distance running and osteoarthritis of the hip, knee or ankle joints, in this case hip joint. The studies have not a clear and common definition of what long-distance running is. The studies reviewed use different metrics to assess joint degeneration, both by self-report and of different diagnostic criteria for osteoarthritis. All studies have an element of selection bias.   Conclusion An indication that there is no scientific evidence that long-distance running gives hip, knee or ankle osteoarthritis in humans. The studies were inadequate handling of confounders and selection bias and judged to be of low or medium quality.

No description available.

One of the most poorly understood co-morbidities associated with obesity is the pathway to osteoarthritis of the knee. To implement appropriate preventative strategies, it is important to explore how obesity is a causal factor for osteoarthritis. The present research compared the kinematics and kinetics of a group of young obese, but otherwise healthy, adults to a group of young, healthy-weight adults, in an attempt to identify mechanical abnormalities at the knee during walking that may predispose the obese to osteoarthritis of the knee. Optotrak motion capture (Northern Digital Inc. Waterloo, Ontario) and a forceplate (AMTI OR6-7, Advanced Mechanical Technology Inc, Watertown, MA) were used to measure ground reaction forces and moments of 16 participants – 8 obese and 8 sex-, age- and height-matched healthy-weight – to analyze knee joint kinematics and kinetics at three walking speeds. Participants wore an accelerometer (ActiGraph GT3X, Fort Walton Beach, USA) for seven days to measure daily steps counts. Dependent t-tests were performed to determine group differences in ground reaction forces, knee angles and knee moments, as well as knee adduction moment impulse and cumulative knee adductor load (CKAL). The obese group walked at a significantly slower self-selected speed (p=0.013). While not statistically significant, the obese group did present with a more valgus mean dynamic knee alignment than the health-weight group. A significantly greater maximum abduction angle (p=0.009) and smaller minimum knee flexion angle at heel contact (p=0.001) was found in the obese group. A significant difference was found in the peak medial rotation moment in the transverse plane (p=0.003). A greater stance duration lead to a significantly greater knee adduction moment impulse (p=0.049) in the obese group. While significant group differences were not found in the steps per day, the obese group had a significantly greater CKAL (p=0.025). Obese young adults with healthy knees demonstrated a gait pattern of reduced medial knee joint compartment loading through greater knee abduction, medial knee rotation and a slower walking speed compared to matched controls. The ramifications of gait modifications on long-term musculoskeletal health remain unknown, but compensations may lead to increased risk of osteoarthritis of the knee.

This scientific paper is about the changes in the skeleton caused by the diseases osteoarthritis and osteoporosis. Six males and one female from Banken 1, S:ta Gertrud  and S:t Hans in Visby were chosen for an osteological analysis. All individuals are adults and dates back to the middle ages. One male suffered from both osteoporosis and osteoarthritis and one female and three males suffered from osteoarthritis. One male might have been in the beginning faze of osteoarthritis, and one male shows no sign of any of the diseases. In addition to osteoarthritis and osteoporosis, some of the individuals suffer from other pathological conditions. Some of the bones from most of the individuals were x-rayed at Visby hospital, to see if medical technique could show some additional information to the osteological analysis. The x-rays were interpreted by doctor Staffan Jennerholm from Visby hospital, but other doctors have also participated. The x-rays confirmed results from the osteological analysis in most cases, although it showed new information in several cases. Some bones from three individuals were taken to Roland Alvarssons` Doctor Practice in Visby to measure the bone density, to check if any of the individuals had osteoporosis. The result confirmed that one male had osteoporosis, as expected from the osteological analysis. / Noen steder i oppgaven står det "osteoartrithis", men det skal stå "osteoarthritis"

Osteoarthritis and ageing have been shown to induce changes in the number and health of peripheral mechanoreceptors. Whilst position and movement awareness in the osteoarthritic knee have been studied extensively, little work to date has been produced on muscle force awareness in this subject group. Poor force acuity may contribute to muscle and joint pain and dysfunction, and additionally hinder rehabilitation efforts in an osteoarthritic population. Overestimation of the muscles forces required for a given task, resulting in greater joint compression forces, may aggravate and inflame osteoarthritic symptoms. Underestimation of required muscle forces may amplify existing joint instability, increasing the risk of injury in an osteoarthritic population. Additionally, both under and overloading of muscles during the rehabilitation process can delay the return to full function after injury.When regarding the neurological process of force coding, current debate centres on the relative importance of centrally generated motor command mediated 'sense of effort' versus the peripheral mechanoreceptor signalled 'sense of tension' as the dominant coding process, with central mechanisms favoured in the majority of studies published to date. The purpose of this study was to investigate muscle force awareness in the knee extensors and flexors and hands of subjects with and without knee joint osteoarthritis. Twenty one subjects with knee joint osteoarthritis and 23 age and gender matched subjects with no known knee pathology were evaluated. All subjects performed ipsilateral isometric force estimation and force matching tasks, at levels scaled to individual maximum voluntary capacity (MVC). Errors in estimation and matching acuity were normalised to reference targets (comparison force/reference force) giving a relative score (RS) to allow comparison across submaximal force levels with RS less than 1.0 indicating that subjects produced insufficient force and vice versa.Maximal voluntary capacity tests revealed significantly lower (p<0.05) peak knee extension torque (111.2 Nm versus 145.3 Nm), but similar peak knee flexion torque (46.1 Nm versus 45.4 Nm for osteoarthritis and control subjects respectively). A pattern of overestimation at low reference levels and underestimation at high reference levels was demonstrated by all subjects. In the lower limb, force appreciation differed significantly between muscle groups regardless of knee condition, with knee extensors demonstrating greater overall accuracy than knee flexors. There was a significant difference (p<0.05) in force estimation ability and a trend to significance (p=0.066) for force matching acuity across groups at the 10% MVC test level. A significant (p<0.05) group difference in grip force estimation ability between the lowest and highest target levels was demonstrated.It can be concluded that there are small differences in force acuity in osteoarthritis subjects at lower submaximal force targets when compared to healthy age matched peers. The notion of information redundancy, whereby no new proprioceptive inputs, regardless of origin, are able to effect an improvement in force acuity in a given situation has been demonstrated in previous studies that reported relatively stable force matching acuity at forces between 30% and 60% of maximal capacity. The poor comparative force perception demonstrated in this study by the osteoarthritis group at the lower submaximal test levels supports the notion that centrally generated copies of motor commands do not provide sufficient data to adequately encode force magnitude at low levels of force generation, evoking a greater reliance data received from peripheral mechanoreceptors. This has significant implications for this subject group given that the majority of daily tasks require only low levels of force generation. Given that perceptive acuity in a variety of sensory modalities has been shown to improve with training there may be a role for force perception training in older adults with osteoarthritis.

Thesis (Ph. D.)--University of Adelaide, Dept. of Pathology, 1984. / Includes bibliographical references (leaves [280]-301).

Thesis (Ph.D.)--University of Western Australia, 2007.

Thesis (Ed.D.) -- Teachers College, Columbia University, 1991. / Typescript; issued also on microfilm. Sponsor: John P. Allegrante. Dissertation Committee: Bernard Gutin. Includes bibliographical references (leaves 171-185).

Zugl.: Berlin, Freie Univ., Diss., 2008

Thesis (M.S.)--Springfield College, 2003. / Includes bibliographical references. Also available online (PDF file) by a subscription to the set or by purchasing the individual file.