Global ETD Search

1	Cyclobutadiene cycloadditions : applications toward the synthesis of functionalized oxepines and guaiane natural products Leyhane, Andrew John January 2008 (has links) Thesis advisor: Marc L. Snapper / Thesis (PhD) — Boston College, 2008. / Submitted to: Boston College. Graduate School of Arts and Sciences. / Discipline: Chemistry. oxepine cyclobutene guaiane synthesis cyclobutadiene
2	Experimental and Computational Studies for Various Organic Systems Xia, Shijing 18 March 2008 (has links) No description available. Chemistry computational experimental radical trityl hydroxyl superoxide oxepine urea capsule
3	Tubulin-binding dibenz[c,e]oxepines. Part 2. 1 Structural variation and biological evaluation as tumour vasculature disrupting agents Rossington, S.B., Hadfield, J.A., Shnyder, Steven, Wallace, T.W., Williams, K.J. 19 January 2017 (has links) Yes / 5,7-Dihydro-3,9,10,11-tetramethoxybenz[c,e]oxepin-4-ol 1, prepared from a dibenzyl ether precursor via Pd-catalysed intramolecular direct arylation, possesses broad-spectrum in vitro cytotoxicity towards various tumour cell lines, and induces vascular shutdown, necrosis and growth delay in tumour xenografts in mice at sub-toxic doses. The biological properties of 1 and related compounds can be attributed to their ability to inhibit microtubule assembly at the micromolar level, by binding reversibly to the same site of the tubulin αβ-heterodimer as colchicine 2 and the allocolchinol, N-acetylcolchinol 4. Intramolecular direct arylation Tubulin targeting Tumour growth inhibition Vascular shutdown Colchicinoid Dibenz[c,e]oxepine
4	Oxidation and Reduction Process for Polycyclic Aromatic Hydrocarbons and Nitrated Polycyclic Aromatic Hydrocarbons Tian, Zhenjiao January 2008 (has links) No description available. Chemistry Pharmacology oxidation epoxidation reduction Hammett Correlation density function computational chemistry polycyclic aromatic hydrocarbons nitrated metabolic activation thermodynamic kinetic enthalpy free energy isomerization oxepine

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