Global ETD Search

1	A Novel Method for Synthesis of Hydroxytyrosol Onobun, Emmanuel 01 August 2017 (has links) Hydroxytyrosol, 3,4-dihydroxyphenolethanol, a naturally occurring polyphenol most common in olive tree (Olea europaea), is one of the most effective member of the polyphenols family, because of its remarkable antioxidant activity, its ability to inhibit oxidation of low density lipids (LDL), and its protection against DNA oxidative damage. Hydroxytyrosol, which is widely used in cosmetics and food supplements industries, can be purchased as an olive oil extract that contains low concentration of hydroxytyrosol besides other polyphenols. The price and low natural abundance of hydroxytyrosol make alternative synthetic sources very attractive. In this research, a novel method for the synthesis of pure hydroxytyrosol from a commercially inexpensive precursor catechol was developed; this can satisfy the increasing market demand and provide a more economical alternative source for this valuable polyphenol. Hydroxytyrosol Catechol Synthesis Novel Antioxidant DNA Damage Acylation oxyplumbation Acetyl Chloride Aluminum Chloride Anticancer High Yield Reaction Biochemistry Cardiovascular Diseases Medicinal-Pharmaceutical Chemistry Organic Chemistry