In this Thesis, we analyze three variational and geometric problems, that extend classical Euclidean issues of the calculus of variations to more general classes of spaces. The results we outline are based on the articles [Ved21; MV21] and on a forthcoming joint work with Nicolussi Golo and Serra Cassano. In the first place, in Chapter 1 we provide a general introduction to metric measure spaces and some of their properties. In Chapter 2 we extend the classical Talenti’s comparison theorem for elliptic equations to the setting of RCD(K,N) spaces: in addition the the generalization of Talenti’s inequality, we will prove that the result is rigid, in the sense that equality forces the space to have a symmetric structure, and stable. Chapter 3 is devoted to the study of the Bernstein problem for intrinsic graphs in the first Heisenberg group H^1: we will show that under mild assumptions on the regularity any stationary and stable solution to the minimal surface equation needs to be intrinsically affine. Finally, in Chapter 4 we study the dimension and structure of the singular set for p-harmonic maps taking values in a Riemannian manifold.