Indiana University-Purdue University Indianapolis (IUPUI) / The purpose of this study was to assess the suitability of a pain model that utilizes the application of force between teeth as the noxious stimulus. Also, the time course of pain threshold alterations in patients subjected to orthodontic treatment was explored. A simple pressure algometer utilizing strain gages was produced to apply and measure the force required to reach the pain threshold of incisor teeth (central-lateral pairs) for three consecutive days. Fifteen orthodontic patients were used (nine females, six males) with incisors in good alignment and with interproximal contact. Each patient was used for both control and experimental measurements in each arch. Baseline pain threshold measurements were taken on the first day and individual orthodontic springs placed on the experimental side. The control side was the adjacent central-lateral incisor pair on the other side of the arch where no spring was placed. Additional measurements were taken the second and third day in each quadrant. A great variability in pain response between patients was evident. Significantly lower pain threshold levels were observed a day after the initial spring activation followed by an increase in the pain threshold the second day after spring activation. In the mandibular arch, the treatment by day interaction was significant, with the experimental side pain threshold substantially lower than control on the second and third day. Pain thresholds in males were significantly higher only in the maxilla, although there was a tendency for lower pain sensitivity in males for both arches. An apparent crossover of sensitivity between arch sides was observed in this study. The present model was shown to be suitable to study pain thresholds associated with orthodontic forces, and the pressure algometer was able to quantify pain threshold with objective measurements. The model could be used clinically to screen patients with low pretreatment pain thresholds so modifications of treatment mechanics or pharmacologic means could be used to allay patient pain.

Diss. (sammanfattning) Stockholm : Karol. inst., 2005. / Härtill 6 uppsatser.

Thesis (Ph.D.)--Ohio University, November, 2004. / Includes bibliographical references (p. 145-172)

Thesis (Ph.D.)--Ohio University, November, 2004. / Title from PDF t.p. Includes bibliographical references (p. 145-172)

Research has shown that the experiences of pain and aggression are linked. Past research supports the notion that individuals with an aggressive history tend to have higher pain thresholds than their less aggressive counterparts. The aim of this study was to test the notion that past aggressive behavior is positively associated with higher pain tolerances, and that higher pain tolerance would be associated with the use of a clearly aggressive response on a laboratory task. Using data from a larger study on the neuroscience of human aggression (N = 80), a serial mediation model was tested using both objective and subjective indexes of pain tolerance as mediators. Results indicated that historic aggression was positively associated with both objective and subjective pain tolerance, and objective pain tolerance mediated the relationship between historic aggression and current aggression, whereas subjective pain tolerance did not.

This study assessed the effect of an eight-minute cycling intervention using varying intensities on exercise-induced hypoalgesia (EIH). Generally, current research examines EIH using protocols that last for more than 10 minutes and reach 75% of an individual's VO2 peak. The main objective of this study was to examine the effect of varying intensities on pressure pain threshold (PPT) and heat pain threshold (HPT) at the thigh and forearm, tested pre- and post-cycling intervention. Healthy male participants (n=16) performed a graded exercise test on a cycle ergometer to establish their peak power output (PPO). In subsequent visits, participants completed five different 8-minute cycling interventions, with intensities randomly assigned to one of three counterbalanced orders. HPT and PPT were applied to the thigh and forearm two times before and after each cycling intervention. Additionally, there was a notable effect of intensity on PPT in the thigh, with significant changes at intensities of 90% (p = 0.024) and 100% (p = 0.003). In the forearm, repeated measures ANOVA indicated that there was no significant interaction or main effect for intensity and time. Similarly, for HPT, the analysis did not show significant interaction or main effects for both intensity and location. This study was the first to examine EIH using an 8-minute cycling intervention on a cycling ergometer at individualized intensities. Higher intensity cycling sessions generated EIH locally in the thigh using PPT. This intervention appeared to target the nociceptors activated by mechanical, rather than thermal stimuli, further highlighting the multi-faceted nature of EIH. A short but high intensity cycling intervention may have clinical relevance, as it can provide an intervention to reduce localized pain immediately after exercise using a pressure pain stimulus.

A Articulação Temporomandibular (ATM) pode ser acometida por inúmeros distúrbios articulares sendo os mais comuns os distúrbios de desarranjo do disco e os distúrbios inflamatórios. Um sinal clínico importante nesses casos é a sensibilidade dolorosa à palpação digital ou por mensuração do Limiar de Dor à Pressão (LDP), determinado com o uso de um instrumento denominado algômetro. O presente trabalho tem o objetivo de determinar qual o valor de LDP que melhor diferencie ATMs saudáveis daquelas acometidas por distúrbios inflamatórios e dolorosos. Ainda propõem-se a determinar se há diferenças entre o LDP de ATMs saudáveis e ATMs com deslocamento de disco com redução (DDCR) assintomáticos. Para isso, foi utilizada uma amostra de 60 indivíduos de ambos os gêneros com idade entre 18 e 50 anos, avaliados pelos critérios do Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) e divididos em três grupos: 20 indivíduos com diagnóstico clínico de artralgia da ATM (com ou sem deslocamento de disco para anterior, 20 indivíduos com diagnóstico clínico de DDCR (assintomáticos) e 20 indivíduos sem dores ou ruídos na ATM (grupo controle). Toda a amostra foi submetida a exame de ressonância magnética para análise da posição do disco para confirmar o exame físico e validar os critérios de inclusão (RDC/TMD) para formação dos grupos. Foram realizados exames de algometria sobre o pólo lateral das ATMs, e obtidas Escalas de Análise Visual (EAV) para o grupo de artralgia. Os dados foram analisados por teste de análise de variância (ANOVA a um critério) e por teste de correlação de Pearson com 5% de significância. Níveis de especificidade e sensibilidade, sendo gerada curva ROC foram também determinados. O valores de LDP foram significantemente menores para o grupo com artralgia (média de 1,07 kgf/cm2 ± 0,445), quando comparados aos outros grupos. Ainda, o grupo com DDCR (média de 1,90 kgf/cm2 ± 0,647) apresentou menores valores quando comparados ao controle (média de 2,46 kgf/cm2 ± 0,593). Não foi encontrada correlação entre o LDP obtido no grupo de artralgia com a EAV e com o tempo de experiência de dor. Quando excelentes valores de sensibilidade e especificidade foram contemplados, verificou-se que o valor de palpação de 1,56 kgf/cm2 é o mais adequado para o diagnóstico de DTM de origem articular. / Temporomandibular Joint (TMJ) internal derangements are characterized by anterior disk displacement (ADD) and/or as arthralgias. An important clinical presentation in these cases is the painful tenderness to manual palpation or decreased Pressure Pain Threshold (PPT), determined with an algometer. The present study aims to determine, based on high specificity levels, the more appropriate PPT value to discriminate healthy TMJs from those with painful inflammatory processes as well as to determine the influence of asymptomatic disk displacement with reduction (DDWR) in this scenario. A sample of 60 individuals from both genders with age between 18 and 50 years were evaluated by Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) and divided into three groups: 20 patients with clinical diagnosis of TMJ arthralgia, 20 patients with clinical diagnosis of asymptomatic DDWR and 20 individuals with no TMJ pain or noise (control group). All individuals were submitted to an exam of magnetic resonance imaging for the analysis of disk position to confirm the physical exam (RDC/TMD) and to validate the group distribution. An algometry exam was performed on the TMJ lateral pole and the individuals of the arthralgia group also filled out a Visual Analogue Scale (VAS). The data were analyzed by variance test (ANOVA) and by Pearson correlation test with 5% of significance. Levels of specificity and sensibility, and ROC curves were also determined. The arthralgia group presented significant lower PPT (mean of 1.07 kgf/cm2 ± 0.445) values than the others. DDWR group (mean of 1.90 kgf/cm2 ± 0.647) has shown significant lower PPT values when compared to the control group (mean of 2.46 kgf/cm2 ± 0.593). A significant correlation between the PPT and the VAS and the time of pain experience was not found. 100% of specificity and 90% of sensitivity were obtained when 1.56 kgf/cm2 was applied to the TMJ (ROC=0.99). This value was considered to be the most appropriate to detected TMJ arthralgia.

O objetivo dessa tese foi avaliar alguns desses fatores, verificar a influência da ortodontia sobre alterações oclusais, limiares de dor à pressão da região orofacial, hábitos orais parafuncionais, e percepção de qualidade de vida. Foram selecionados 111 pacientes com idade entre 13 e 55 anos e ausência de sintomas de DTM que iniciaram terapia ortodôntica corretiva. O experimento foi dividido em três etapas: t1 (no momento da instalação do aparelho), t2 (2 meses após o início do tratamento), e t3 (6 meses após o início do tratamento). Em todas etapas os pacientes foram examinados clinicamente para avaliação oclusal e seus limiares de dor à pressão foram avaliados com um algômetro digital. Também foram aplicados questionários sobre hábitos orais parafuncionais (OBC) e percepção de saúde oral na qualidade de vida (OHIP-14br). Foram feitas comparações a respeito de cada variável quantitativa considerando os três tempos de avaliação por meio de Análise de variância (ANOVA) a um critério. O teste t foi utilizado para avaliar diferenças entre as médias das variáveis quantitativas no tempo inicial (t1) e tempo final (t3) de avaliação. Para avaliar o efeito da ortodontia sobre variáveis qualitativas oclusais foi utilizado o teste exato de Fisher. Foram considerados estatisticamente significantes aqueles resultados que apresentaram nível de significância igual ou menor que 0,05. Nenhum dos 111 pacientes desenvolveram sintomas de DTM até o momento final de avaliação. Não foram observadas mudanças oclusais quantitativas significativas (p>0,05) entre t1 e t3, no entanto os fatores qualitativos como mudanças nos padrões oclusais foram alterados significativamente (p<0,05). O tratamento ortodôntico não alterou os limiares de dor à pressão, mas foi observado um aumento significativo (p<0,05) nos escores de OHIP entre os períodos t1 e t3. O tratamento ortodôntico também não aumentou ou diminuiu a presença de hábitos orais parafuncionais, e não foram encontradas diferenças entre sexo e Limear de Dor a Pressão (LDP) nos indivíduos que possuíam mais ou menos hábitos. No entanto, pacientes mais velhos relataram maiores escores de OBC, e foi encontrada correlação entre pacientes com maiores escores de OBC e menores escores para o OHIP. O estudo concluiu que a movimentação ortodôntica não teve efeito sobre limiares de dor na região orofacial e não influencia na presença de hábitos orais parafuncionais. No entanto, o tratamento ortodôntico teve um efeito positivo sobre a percepção de saúde oral na qualidade de vida. / The aim of this thesis was to evaluate some of these factors, examining the influence of orthodontics on occlusal changes, pain pressure thresholds of the orofacial region, parafunctional oral habits, and the perception of quality of life. 111 patients aged 13 to 55 that showed no signs or symptoms of TMD and began orthodontic treatment were selected. The experiment was divided into three phases: t1 (when the orthodontic device was installed), t2 (two months after the installation), and t3 (six months after the start of the treatment). At all phases, the patients were examined clinically for occlusal evaluation and their pain pressure thresholds were assessed with an analog algometer. They were also applied questionnaires on parafunctional oral habits (OBC) and perception of oral health on the quality of life (OHIP-14br). Comparisons were made with respect to each quantitative variable considering the three phases of evaluation through a one-way analysis of variance (ANOVA) for each variable. The t test was used to assess differences between the means of quantitative variables at baseline (T1) and the final evaluation (t3). To evaluate the effect of orthodontics on occlusal qualitative variables Fisher\'s exact test was used. Statistical significance was considered for those results with a significance level equal to or less than 0.05. None of the 111 patients developed symptoms of TMD within the evaluation time. No significant occlusal quantitative changes were observed (p> 0.05) between t1 and t3, however the qualitative factors considered as occlusal patterns were significantly changed (p <0.05). Orthodontic treatment did not alter pain pressure thresholds but a significant increase (p <0.05) in scores of OHIP was observed between phases t1 and t3. Orthodontic treatment did not increase or decrease the pesence of parafunctional oral habits, and no differences were found between sex and LDP in individuals who possessed more/less parafunctional habits. However, older patients reported higher OBC scores, and correlation was found between patients with higher OBC scores and lower scores for OHIP. The study concluded that orthodontic treatment did not have an effect on orofacial pain hresholds, nor the presence of parafunctional oral habits. The perception of oral health on quality of life improved significantly with treatment and patients with lessparafunctional oral habits presented a better quality of life.

Thesis (M.Ost.)--Unitec New Zealand, 2006. / Includes bibliographical references (leaves 50-53).

O objetivo dessa tese foi avaliar alguns desses fatores, verificar a influência da ortodontia sobre alterações oclusais, limiares de dor à pressão da região orofacial, hábitos orais parafuncionais, e percepção de qualidade de vida. Foram selecionados 111 pacientes com idade entre 13 e 55 anos e ausência de sintomas de DTM que iniciaram terapia ortodôntica corretiva. O experimento foi dividido em três etapas: t1 (no momento da instalação do aparelho), t2 (2 meses após o início do tratamento), e t3 (6 meses após o início do tratamento). Em todas etapas os pacientes foram examinados clinicamente para avaliação oclusal e seus limiares de dor à pressão foram avaliados com um algômetro digital. Também foram aplicados questionários sobre hábitos orais parafuncionais (OBC) e percepção de saúde oral na qualidade de vida (OHIP-14br). Foram feitas comparações a respeito de cada variável quantitativa considerando os três tempos de avaliação por meio de Análise de variância (ANOVA) a um critério. O teste t foi utilizado para avaliar diferenças entre as médias das variáveis quantitativas no tempo inicial (t1) e tempo final (t3) de avaliação. Para avaliar o efeito da ortodontia sobre variáveis qualitativas oclusais foi utilizado o teste exato de Fisher. Foram considerados estatisticamente significantes aqueles resultados que apresentaram nível de significância igual ou menor que 0,05. Nenhum dos 111 pacientes desenvolveram sintomas de DTM até o momento final de avaliação. Não foram observadas mudanças oclusais quantitativas significativas (p>0,05) entre t1 e t3, no entanto os fatores qualitativos como mudanças nos padrões oclusais foram alterados significativamente (p<0,05). O tratamento ortodôntico não alterou os limiares de dor à pressão, mas foi observado um aumento significativo (p<0,05) nos escores de OHIP entre os períodos t1 e t3. O tratamento ortodôntico também não aumentou ou diminuiu a presença de hábitos orais parafuncionais, e não foram encontradas diferenças entre sexo e Limear de Dor a Pressão (LDP) nos indivíduos que possuíam mais ou menos hábitos. No entanto, pacientes mais velhos relataram maiores escores de OBC, e foi encontrada correlação entre pacientes com maiores escores de OBC e menores escores para o OHIP. O estudo concluiu que a movimentação ortodôntica não teve efeito sobre limiares de dor na região orofacial e não influencia na presença de hábitos orais parafuncionais. No entanto, o tratamento ortodôntico teve um efeito positivo sobre a percepção de saúde oral na qualidade de vida. / The aim of this thesis was to evaluate some of these factors, examining the influence of orthodontics on occlusal changes, pain pressure thresholds of the orofacial region, parafunctional oral habits, and the perception of quality of life. 111 patients aged 13 to 55 that showed no signs or symptoms of TMD and began orthodontic treatment were selected. The experiment was divided into three phases: t1 (when the orthodontic device was installed), t2 (two months after the installation), and t3 (six months after the start of the treatment). At all phases, the patients were examined clinically for occlusal evaluation and their pain pressure thresholds were assessed with an analog algometer. They were also applied questionnaires on parafunctional oral habits (OBC) and perception of oral health on the quality of life (OHIP-14br). Comparisons were made with respect to each quantitative variable considering the three phases of evaluation through a one-way analysis of variance (ANOVA) for each variable. The t test was used to assess differences between the means of quantitative variables at baseline (T1) and the final evaluation (t3). To evaluate the effect of orthodontics on occlusal qualitative variables Fisher\'s exact test was used. Statistical significance was considered for those results with a significance level equal to or less than 0.05. None of the 111 patients developed symptoms of TMD within the evaluation time. No significant occlusal quantitative changes were observed (p> 0.05) between t1 and t3, however the qualitative factors considered as occlusal patterns were significantly changed (p <0.05). Orthodontic treatment did not alter pain pressure thresholds but a significant increase (p <0.05) in scores of OHIP was observed between phases t1 and t3. Orthodontic treatment did not increase or decrease the pesence of parafunctional oral habits, and no differences were found between sex and LDP in individuals who possessed more/less parafunctional habits. However, older patients reported higher OBC scores, and correlation was found between patients with higher OBC scores and lower scores for OHIP. The study concluded that orthodontic treatment did not have an effect on orofacial pain hresholds, nor the presence of parafunctional oral habits. The perception of oral health on quality of life improved significantly with treatment and patients with lessparafunctional oral habits presented a better quality of life.