Diss. (sammanfattning) Stockholm : Karol. inst., 2003. / Härtill 5 uppsatser.

Thesis (Ph.D.)--University of Alabama at Birmingham, 2009. / Title from first page of PDF file (viewed on June 10, 2009). Includes bibliographical references.

Thesis (Ph. D.)--University of Washington, 2007. / Vita. Includes bibliographical references (leaves 54-62).

O tamanduá-bandeira Myrmecophaga tridactyla é uma espécie considerada “vulnerável” no Brasil, por estar ameaçado de extinção em algumas regiões do país. O presente projeto teve por objetivo identificar e caracterizar as estruturas macro e microscópicas do pâncreas nessa espécie. Para tanto, foram dissecados 16 pâncreas de tamanduás-bandeira provenientes do Hospital Veterinário “Dr. Halim Atique” do Centro Universitário de Rio Preto (UNIRP). As amostras coletadas, foram provenientes de casos de animais atendidos no referido Hospital e que vieram a óbito. O pâncreas situava-se no antímero esquerdo do corpo do animal, apresentava coloração pálida, corpo central e superfície lobulada. Acompanhava a curvatura ventricular maior do estomago aderindo-se na porção inicial do duodeno. Relaciona-se crâniodorsalmente com o baço e ventrículo gástrico, e caudoventralmente com a cápsula fibrosa renal (que aloja o rim esquerdo) e intestinos. Estruturalmente, o órgão demonstrou duas partes distintas: a primeira delas com características exócrinas, composta por ácinos pancreáticos e a segunda endócrina, formada pelas ilhotas pancreáticas encontradas nas regiões media, caudoventral e lobar esquerda. A analise ultraestrutural permitiu identificar nas células centro-acinosas do pâncreas vesículas com grânulos de zimogênio, mitocôndrias, Aparelho de Golgi e retículo endoplasmático rugoso / The giant anteater Myrmecophaga tridactyla is a species considered 'vulnerable' in Brazil since it is threatened in some Brazilian regions. This study aimed to identify and characterize morphological structures of the pancreas in this species. For this, 16 anteaters pancreas from the Veterinary Hospital "Dr. Halim Atique at University Center of Rio Preto (UNIRP), were dissected. All samples were from animals treated at the hospital which died of natural causes. The pancreas was located in the left antimere of the animal’s body, being lobulated and having a pale color and central body. It followed the greater curvature of the stomach, adhering on the initial portion of the duodenum. It was craniodorsally related to the spleen and gizzard, and caudoventrally to the renal fibrous capsule (which houses the left kidney) and intestines. Structurally, the organ had two distinct parts: an exocrine, composed of pancreatic acini; and and endocrine, formed by pancreatic islets found in the medial, caudoventral and left lobar regions. The ultrastructural analysis allowed identifying the central-acinar pancreatic cells with vesicles zymogen granules, mitochondria, Golgi apparatus and rough endoplasmic reticulum

京都大学 / 0048 / 新制・課程博士 / 博士(医学) / 甲第19567号 / 医博第4074号 / 新制||医||1013(附属図書館) / 32603 / 京都大学大学院医学研究科医学専攻 / (主査)教授 武田 俊一, 教授 小川 誠司, 教授 野田 亮 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM

京都大学 / 0048 / 新制・課程博士 / 博士(医学) / 甲第20794号 / 医博第4294号 / 新制||医||1025(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 妹尾 浩, 教授 浅野 雅秀, 教授 川口 義弥 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM

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Background Pancreatic heterotopia (PH) is defined as ectopic pancreatic tissue outside the normal pancreas and its vasculature and duct system. Most frequently, PH is detected incidentally by histopathological examination. The aim of the present study was to analyze a large single-center series of duodenal PH with respect to the clinical presentation. Methods A prospective pancreatic database was retrospectively analyzed for cases of PH of the duodenum. All pancreatic and duodenal resections performed between January 2000 and October 2015 were included and screened for histopathologically proven duodenal PH. PH was classified according to Heinrich’s classification (Type I acini, ducts, and islet cells; Type II acini and ducts; Type III only ducts). Results A total of 1274 pancreatic and duodenal resections were performed within the study period, and 67 cases of PH (5.3%) were identified. The respective patients were predominantly male (72%) and either underwent pancreatoduodenectomy (n = 60); a limited pancreas resection with partial duodenal resection (n = 4); distal pancreatectomy with partial duodenal resection (n = 1); total pancreatectomy (n = 1); or enucleation (n = 1). Whereas 65 patients (83.5%) were asymptomatic, 11 patients (18.4%) presented with symptoms related to PH (most frequently with abdominal pain [72%] and duodenal obstruction [55%]). Of those, seven patients (63.6%) had chronic pancreatitis in the heterotopic pancreas. The risk of malignant transformation into adenocarcinoma was 2.9%. Conclusions PH is found in approximately 5% of pancreatic or duodenal resections and is generally asymptomatic. Chronic pancreatitis is not uncommon in heterotopic pancreatic tissue, and even there is a risk of malignant transformation. PH should be considered for the differential diagnosis of duodenal lesions and surgery should be considered, especially in symptomatic cases.

Background Pancreatic heterotopia (PH) is defined as ectopic pancreatic tissue outside the normal pancreas and its vasculature and duct system. Most frequently, PH is detected incidentally by histopathological examination. The aim of the present study was to analyze a large single-center series of duodenal PH with respect to the clinical presentation. Methods A prospective pancreatic database was retrospectively analyzed for cases of PH of the duodenum. All pancreatic and duodenal resections performed between January 2000 and October 2015 were included and screened for histopathologically proven duodenal PH. PH was classified according to Heinrich’s classification (Type I acini, ducts, and islet cells; Type II acini and ducts; Type III only ducts). Results A total of 1274 pancreatic and duodenal resections were performed within the study period, and 67 cases of PH (5.3%) were identified. The respective patients were predominantly male (72%) and either underwent pancreatoduodenectomy (n = 60); a limited pancreas resection with partial duodenal resection (n = 4); distal pancreatectomy with partial duodenal resection (n = 1); total pancreatectomy (n = 1); or enucleation (n = 1). Whereas 65 patients (83.5%) were asymptomatic, 11 patients (18.4%) presented with symptoms related to PH (most frequently with abdominal pain [72%] and duodenal obstruction [55%]). Of those, seven patients (63.6%) had chronic pancreatitis in the heterotopic pancreas. The risk of malignant transformation into adenocarcinoma was 2.9%. Conclusions PH is found in approximately 5% of pancreatic or duodenal resections and is generally asymptomatic. Chronic pancreatitis is not uncommon in heterotopic pancreatic tissue, and even there is a risk of malignant transformation. PH should be considered for the differential diagnosis of duodenal lesions and surgery should be considered, especially in symptomatic cases.