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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
101

Host-pathogen interactions in chronic infections

Arnold, Markus F. F. January 2012 (has links)
The BacA protein plays a key role in the symbiosis of Sinorhizobium meliloti with the leguminous plant alfalfa (Medicago sativa) and is proposed to be the transmembrane subunit of an ATP‐binding cassette (ABC) transporter. BacA homologues are also present in Brucella species, enteric bacteria (known as SbmA) and Mycobacterium tuberculosis. The S. meliloti‐alfalfa symbiosis, although beneficial to both partners, can also be viewed as a chronic infection. The M. tuberculosis BacA protein is important for M. tuberculosis for the maintenance of a chronic infection. In order to study the M. tuberculosis BacA protein a codon optimised M. tuberculosis bacA gene was synthesised and cloned into vectors for expression in an S. meliloti ΔbacA mutant. Evidence is presented that M. tuberculosis BacA sensitises an S. meliloti ΔbacA mutant towards the glycopeptide bleomycin and the truncated proline rich peptide Bac71‐16, and further that a functional ATPase domain is essential to perform BacA mediated peptide transport. The M. tuberculosis BacA protein protected an S. meliloti ΔbacA mutant from being killed by host defensins. In addition, it was determined that M. tuberculosis BacA‐mediated protection of the legume symbiont S. meliloti against legume defensins as well as mouse alveolar lavages and human ‐defensin 2 is dependent on an ATPase domain which is present in the M. tuberculosis BacA protein. M. tuberculosis encounters ‐defensins during mammalian infections in the host’s lungs and my data show that BacA is likely to be important in conferring immunity to these peptides. The mechanism of persistent infection by M. tuberculosis is therefore very reminiscent of the Sinorhizobium ‐ legume interaction. Also Salmonella enterica is able to cause asymptomatic infections and about 5% of these develop a chronic carrier state and are able to spread the pathogen. In enteric bacterial species SbmA is in close proximity to the putative lipoprotein YaiW. In this study it was determined that YaiW is exposed on the cell surface and that it is involved in the protection of E. coli and potentially Salmonella spp. against a cysteine rich host peptide. YaiW is potentially involved in swarming motility. It was also determined that an alfalfa plant infection model can distinguish between Salmonella strains forming acute and chronic infections. Staphylococcus aureus is one of the major hospital acquired and opportunistic pathogens. Asymptomatic carriers, infected with multi‐drug resistant strains (MRSA) pose a threat to immunocompromised individuals. Here, novel compounds and ways from a variety of sources have been tested for their potential antimicrobial activity against a range of multi‐drug resistant clinical S. aureus isolates. This project significantly advanced the molecular understanding of asymptomatic bacteria‐host infections and helped to understand and establish novel ways to treat infections with multi‐drug resistant clinical pathogens.
102

Host-pathogen interactions in lentiviral post-entry restriction and nuclear import

Price, Amanda Jane January 2011 (has links)
No description available.
103

Studies on the pathophysiology of parasitic disease.

Symons, Lawrence Eric Alexander. January 1900 (has links) (PDF)
Thesis (D.Sc.1974) from the Dept. of Entomology, University of Adelaide.
104

Plasmodium chabaudi adami : vaccine antigens and antigenic variation /

Bucsu, Eva. January 2003 (has links)
Thesis (Ph.D.)--University of Melbourne, Dept. of Medical Biology, 2003. / Typescript (photocopy). Includes bibliographical references (leaves 161-194).
105

Brood size and offspring sex ratio of the intertidal amphipod, Corophium volutator (Pallas): apparent effects of a novel microsporidian /

Cook, Kathleen A., January 1900 (has links)
Thesis (M.Sc.) - Carleton University, 2006. / Includes bibliographical references (p. 54-74). Also available in electronic format on the Internet.
106

Studies on the host-parasite relationships in experimental trypanosomiasis with Trypanosoma equiperdum and various laboratory animals

Carter, Thomas Chauncey. January 1930 (has links)
Thesis (Ph. D.)--University of Wisconsin--Madison, 1930. / Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 49-51).
107

Host-pathogen interactions between the fungal pathogen Phloeospora mimosae-pigrae and Mimosa pigra, giant sensitive plant /

Hennecke, Berthold Rembertus. January 2002 (has links) (PDF)
Thesis (Ph.D.) - University of Queensland, 2003. / Includes bibliography.
108

The biology of Thysanosoma actinioides (Cestoda: anoplocephalidae) a parasite of ruminants /

Allen, Rex Wayne. January 1970 (has links)
Thesis--University of Wisconsin. / Includes bibliographical references (leaves 113-120).
109

Interaction of Pseudomonas solanacearum with tobacco cell walls and with a wall-associated agglutinin

Duvick, Jonathan Paul. January 1982 (has links)
Thesis (Ph. D.)--University of Wisconsin--Madison, 1982. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 137-153).
110

A fine structure study of the host-parasite interactions of three fungal diseases

Camp, Russell Rufus, January 1970 (has links)
Thesis (Ph. D.)--University of Wisconsin, 1971. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliography.

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