Orientador: Antônio Wilson Sallum / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba / Made available in DSpace on 2018-08-22T14:55:04Z (GMT). No. of bitstreams: 1 Barbosa_VivieneSantana_M.pdf: 2692982 bytes, checksum: 8a2987c554b7ba34f2d70f33080eb9f6 (MD5) Previous issue date: 2013 / Resumo: O objetivo desse estudo foi avaliar, histológica e microbiologicamente, a ação da TFD, da clorexidina a 0,12% (CLX) e do iodo povidine a 10% (PVP-I), na periodontite experimental induzida em ratos. Para isso, 28 ratos Wistar receberam bilateralmente inserção de ligadura ao redor dos primeiros molares inferiores no baseline. Os lados foram aleatoriamente escolhidos para receber só inserção de ligadura (grupo controle) ou ligadura e uma das seguintes terapias: PVP-I a 10% (n=10), CLX a 0,12% (n=8) e TFD (n=10). Cada grupo recebeu o respectivo tratamento em três períodos: 7, 14 e 21 dias após indução da periodontite. Histometricamente, não foi observada diferença estatística na avaliação intergrupo e intragrupo, no que diz respeito à redução da reabsorção óssea alveolar (p>0,05). Histoquimicamente, a avaliação intragrupo mostrou que o grupo TFD apresentou um número menor de células TRAP-positivas/mm quando comparado o lado tratado com o lado não-tratado (p<0,05). No entanto, não houve diferença estatística nos grupos CLX e PVP-I, quando avaliados os respectivos lados que receberam terapia e os lados controle. Na avaliação entre as terapias, não foi possível verificar diferenças significativas na contagem de células TRAP-positivas em todos os grupos avaliados (p>0.05). Na avaliação microbiológica, houve uma redução significativa na carga microbiana nos molares tratados com PVP-I (p=0,03), apontando uma boa efetividade do tratamento. Dentre os molares tratados com CLX, houve uma tendência positiva para redução microbiana através dessa terapia (p=0,10). A TFD apresentou um efeito antimicrobiano apenas em alguns animais, porém sem diferença significativa entre o lado tratado e não tratado (p=0,54). Sendo assim, pode-se concluir que os três agentes mostraram um efeito antimicrobiano sobre os microrganismos totais, porém, como terapia, somente o PVP-I foi eficaz na redução do biofilme bacteriano. No que diz respeito à reabsorção, as três terapias não foram capazes de impedir a reabsorção óssea alveolar nos molares dos ratos ao final dos 21 dias de estudo / Abstract: The aim of this study was to evaluate histologically and microbiologically, the action of PDT, of the chlorhexidine 0.12% (CLX) and povidone iodine 10% (PVP-I) in a experimental rat periodontal disease model. For this purpose, 28 Wistar rats received bilateral ligature in both mandible first molars at baseline. The sides were randomly assigned to receive ligature only (control group) or ligature and one of the following therapies: PVP-I 10% (n=10), chlorhexidine 0.12% (n=8) and PDT (n=10). Each group received their treatment in three periods: 7, 14 and 21 days. Histometrically, no statistical difference was seen in the intragroup and intergroup evaluation, regarding the reduction of alveolar bone resorption (p>0.05). Histochemically, the evaluation intragroup showed that the group of PDT showed a smaller number of cells TRAP-positivas/mm when compared to CLX group (p<0.05). However, there was no statistical difference in the groups CLX and PVP-I, when evaluated the respective sides receiving therapy and control sides. In the evaluation of therapies, it was not possible to verify significant differences in counting TRAP-positive cells in all groups (p> 0.05). In microbiological evaluation, there was a significant reduction in microbial load in molars treated with PVP-I (p=0.03), indicating a good treatment effectiveness. Among the molars treated with CLX, there was a positive trend towards reduction through this therapy (p=0.10). PDT showed an antimicrobial effect only in some animals, but no significant difference between the treated side and untreated (p=0.54). Therefore, one can conclude that the three agents shown an antimicrobial effect on the total microorganisms, however, as the therapy, only the PVP-I was effective in reducing the bacterial biofilm. With respect to absorption, the three treatments were not able to prevent alveolar bone resorption in molars of the rats at the end of the 21 day study / Mestrado / Periodontia / Mestra em Clínica Odontológica

Orientadores: Sergio de Toledo, Antonio Wilson Sallum / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba / Made available in DSpace on 2018-08-04T03:45:17Z (GMT). No. of bitstreams: 1 Rodrigues_IvanaFerreiraGomes_M.pdf: 1979982 bytes, checksum: 9156f761fe75412d468296b2a79275be (MD5) Previous issue date: 2005 / Resumo: O objetivo deste estudo foi avaliar clinicamente a utilização de um dispositivo de liberação lenta de clorexidina (PerioChip®) em pacientes engajados na Terapia Periodontal de Suporte (TPS) que ainda apresentavam áreas com sangramento à sondagem e profundidade de sondagem > 5mm e < 8mm em dentes anteriores. Foram utilizados 42 pacientes com boa saúde geral, sendo 21 pacientes no grupo teste (PerioChip®) e 21 no grupo controle (raspagem e alisamento radicular) distribuídos aleatoriamente. Os parâmetros Índice de Placa (IP), Índice Gengival (IG), Sangramento à Sondagem (SS), Profundidade de Sondagem (PS), Recessão Gengival (RG) e Nível de Inserção Clínica (NIC) foram avaliados nos períodos inicial, 6, 12 e 24 semanas. Ao término das 24 semanas, a profundidade de sondagem reduziu 2,64 + 0,02mm no grupo teste e 2,12 + 0,02mm no grupo controle (p > 0,05); o ganho de inserção clínica foi de 2,19 + 0,87mm no grupo teste e 2,07 + 1,53mm no grupo controle (p > 0,05); ambos os tratamentos mostraram diferenças intragrupo estatisticamente significantes. Com as limitações do presente estudo, pode-se concluir que os tratamentos avaliados foram igualmente efetivos em proporcionar ganho de inserção clínica em pacientes na terapia de suporte periodontal. Entretanto, considerando as bolsas periodontais profundas, o dispositivo de liberação lenta de clorexidina foi mais eficiente do que a raspagem e alisamento radicular quanto à redução na profundidade de sondagem / Abstract: The aim of this study was to clinically evaluated the use of PerioChip® in sites showing bleeding on probing and pocket depth ranging from 5mm to 8mm (anterior teeth) in maintenance patients. Forty two patients that consented to participate in the study were randomly assigned to two groups test, treated with PerioChip® and control, treated by scaling and root planing. Patients were assessed for plaque index (PI), gingival index (GI), bleeding on probing (BOP), pocket depth (PD), clinical attachment level (CAL) and gingival recession (GR) at baseline, 6, 12 and 24 weeks. After 24 weeks, a reduction of 2,64 + 0,02mm and 2,12 + 0,02mm in PD was observed for the test and control group (p > 0,05), respectively. The observed gain in CAL was 2,19 + 0,87mm and 2,07 + 1,53mm for the test and control group (p > 0,05), respectively. In both treatments, the intragroup comparisons showed statistically significant differences in the parameters evaluated. Within the limits of this study, it can be concluded that both treatments were equally effective in the reestablishment of periodontal health in inflamed sites of maintenance patients. However, considering the deep periodontal pocket, the PerioChip® was more efficient than the scaling and root planing as for the reduction in the probing depth / Mestrado / Periodontia / Mestre em Clínica Odontológica

Magister Scientiae - MSc / Periodontitis is a bacterially induced chronic inflammatory disease that destroys the supporting tissues of teeth. Clinical observations and experimental evidence indicates that there is a genetic influence of risk factors for periodontitis. A specific pattern of IL-1 polymorphisms (known as the composite IL-1 genotype) has been found to influence the severity of chronic periodontitis. The objective of this study was to evaluate the association between the IL-1 gene polymorphisms and the severity of periodontal disease in a selected Xhosa ppopulation of South africa. / South Africa

The prevalence of Osteogenesis imperfecta type III (OI III) as a category of the inherited connective tissue disorders in South Africa is of paramount importance. Although worldwide, autosomal recessive(AR) OI is rare, it had emerged that the frequency of OI III is relatively high in the indigenous Black African population of South Africa. A review of the literature revealed a paucity of information regarding the dental and craniofacial manifestations of the disorder in this ethnic group. For these reasons, the central theme of this thesis is the identification, documentation and analysis of these features in individuals with OI III in the Black African population of SA. Osteogenesis imperfecta type III (OMIM 259420) is a severe autosomal recessive disorder in which frequent fractures and progressive limb and spinal deformity result in profound physical disability. The condition is heterogeneous and dentin genesis imperfecta (DI) is an important syndromic component of some types of OI III. Other maxillofacial and dental manifestations also have significant implications in terms of management.

No description available.

The purpose of this study was to investigate if the addition of biologic materials and/or oral steroids would affect horizontal bone gain, or the bone density of the grafted bone in horizontal alveolar ridge augmentations. A retrospective chart review was completed to assess the clinical and radiographic outcomes of 53 ridge augmentation patients. An average bone gain of 3.6mm of width was found in our study based on radiographic analysis. There were no statistically significant differences found in the linear bone gain with the addition of biologic materials and steroids. A marginally statistically significant difference was found in the bone density when biologics were added (p-value=0.0653). No statistically significant difference found in the bone density with the addition of oral steroids. The use of tenting screws and resorbable occlusive membranes and a combination of allograft and xenograft bone materials provides significant clinical and radiographic dimensional changes in alveolar ridge width.

Thesis (M.S.)--University of Michigan, 1986.

Thesis (M.S.)--University of Michigan, 1971.

Thesis (M.S.)--University of Michigan, 1971.

Thesis (M.S.)--University of Michigan, 1986.