The evolution of human beings is marked by adaptation. The ability to adapt to and manipulate our environment is one definer of intelligence, and ours is unique among life on Earth. Since moving off of the African Continent, humans have migrated to inhabit every part of the Earth. Human existence and perpetuity in the universe depends upon the success of this adaptation, and inevitably, migrating off of this planet. The technological advances being developed today will change our way of life, and enable people to travel to and live permanently on the Moon and Mars. This study involves the architectural design and construction of a completely programmable permanent Martian settlement in the year 2050. Previous studies and proposals for Martian architecture rely mostly on existing technology. The first people are not expected to reach Mars until 2030, and new and emerging technologies will radically affect the designs being considered today. Technical challenges constrain designers of space architecture today, and scientific developments will solve many of these. This study seeks to explore how new technology can positively affect the architecture of the future, affording more comfortable and livable space on Mars. With a construction date of 2050, this project differs from others by benefitting from the next four decades of profound technological advancement. Leading Futurist Raymond Kurzweil predicts that the technological singularity is within this time frame, and that the 21st Century will, “Witness on the order of 20,000 years of progress (at today’s rate of progress) (Kurzweil, Law of Accelerating Change).” This thesis theorizes that nanotechnology will enable the deployment of a completely self-constructing and programmable permanent Martian settlement designed from a series of spatial modules. The anticipated results include a modular system of architectural spaces, and an increased awareness of the architectural benefits of emerging technologies as they relate to future space architecture.