The COVID-19 pandemic has had a major impact on Swedish business owners. Based on conservation of resources theory, it was predicted that two stressors (perceived uncertainty and financial prognosis) and one resource (eudaimonic well-being) are predictors of personal and financial success of business owners during the COVID-19 pandemic. Moreover, moderation effects of eudaimonic well-being on uncertainty and financial prognosis on both success aspects were hypothesized. Data from 210 Swedish business owners were collected during May-June 2020 (Time 1), of these 67 participated a second time in February 2021 (Time 2). Using hierarchical multiple regression analyses over different time periods, results revealed that uncertainty and financial prognosis were negatively associated with personal and financial success. The hypothesized moderation effects of eudaimonic well-being were not significant. Results were relatively stable for the different time periods and longitudinal associations were found.