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1	Klinická variabilita vzácných demencí a její možné příčiny / Clinical variability of rare dementias: manifestations and possible reasons Tesař, Adam January 2021 (has links) Clinical variants of dementia are limiting their diagnosis and can leads to underdiagnosing or substitution of two different diseases with the same symptomatology. The aim of this study is a better understanding of a factors involved in the clinical variability of rare dementias. Progressive supranuclear palsy and Gerstmann-Sträussler-Scheinker syndrome caused by mismatch mutation P102L in Prion protein are used as model diseases. In this thesis, we firstly demonstrate the influence of the distribution of neuropathology and its spread on the clinical phenotype of the disease. Although a single neurodegenerative disease increases the risk of neurodegenerative comorbidity, this other neuropathology does not affect the phenotypic presentation of the primary disease. Monogenetically inherited proteinopathies can have a different clinical subtype, which is not only conditioned by causal protein polymorphisms, but can be influenced by the wild type allele of causal protein. A more accurate understanding of the symptomatic variability in dementias will allow a better focus of a drug studies and, in the future a treatment, but it will also lead to a better understanding of the pathogenesis of neurodegenerative diseases. Keywords: dementia, Progressive supranuclear palsy, Gerstmann-Sträussler-Scheinker...
2	Pflanze-Herbivore-Parasitoid Interaktionen auf Wildrosenarten und ihren Hybriden entlang eines geographischen Gradienten / Plant-herbivore-parasitoid interations on dog rose species and their hybrids along a geographic gradient Klinge, Katrin 19 January 2006 (has links) No description available. 590 Tiere (Zoologie) WN Mathematics and Natural Science Hundsrosen Phänotyp Rhagoletis alternata Diplolepis rosae Phragmidium phytophage Insekten Hybridisierung Allozyme genetische Differenzierung multitrophische Interaktionen geographischer Gradient Fressbarkeit Spodoptera littoralis Rosa canina Rosa corymbifera Rosa rubiginosa dog roses phenotyp Rhagoletis alternata <si>Diplolepis rosae Phragmidium phytophagous insects hybridisation allozymes genetic differentiation multitrophic interactions geographic gradient palatability Spodoptera littoralis Rosa canina Rosa corymbifera Rosa rubiginosa 42.65 Tiergeographie Tierökologie

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Klinická variabilita vzácných demencí a její možné příčiny / Clinical variability of rare dementias: manifestations and possible reasons

Pflanze-Herbivore-Parasitoid Interaktionen auf Wildrosenarten und ihren Hybriden entlang eines geographischen Gradienten / Plant-herbivore-parasitoid interations on dog rose species and their hybrids along a geographic gradient