Typescript, etc. / Digitized by Kansas Correctional Industries

Thesis--Wisconsin. / Includes bibliographical references (leaves 23-25).

Thesis--Wisconsin. / Vita. Includes bibliographical references (leaves 93-100).

Thesis (M.D.)--University of Adelaide, Faculty of Medicine, 1984. / Articles and serials related to the thesis research bound in appendix. Includes bibliographical references.

No description available.

No description available.

The induction of phenylketonuria in mice through the use of excess dietary phenylalanine is an area in which limited research has been done. This study intends to pursue further work in this area, more specifically, to study the effects of excess dietary phenylalanine and the phenylalanine analogue A.P.B.A. (2-amino-3-phenyl butanoic acid) (7) on brain serotonin and brain norepinephrine. In addition, the effects of these two compounds on the incidence of audiogenic seizures will be explored.

No description available.

Research paper (M.A.) -- Cardinal Stritch College -- Milwaukee, 1969. / A research paper submitted in partial fulfillment of the requirements for the degree of Master of Arts in Education (Education of Mentally Handicapped). Includes bibliographical references (p. 25-27).

Phenylalanine hydroxylase deficiency causes phenylketonuria (PKU) in humans. PKU is a recessive genetic disease that affects 1 in 10000 births among the Caucasian population. Its gene locus is highly polymorphic in its DNA sequence among different individuals and patients with PKU. DNA polymorphisms at the PAH gene locus are used to obtain haplotypes through restriction enzyme analysis. So far forty-six distinct RFLP haplotypes have been discovered in the human population. In theory, 384 distinct RFLP haplotypes can exist. This project is to develop a program to assist the geneticists by obtaining haplotypes for each member of the PKU family. It uses information obtained from digestion of the DNA samples from the family members with the restriction enzymes. The restriction enzymes employed for this purpose are Pvuii, Bglii, EcoRI, Mspi, Xmni, Hindiii, and EcoRV. The program "PKU" generates all possible haplotypes for each member of the PKU family. The generated haplotypes may include haplotypes from the forty-six defined haplotypes list or from the 338 other haplotypes that may fit the description from the restriction enzyme analysis. The program then carries out an elimination phase during which the "extra" haplotypes that had been generated for the family members but whose presence was not supported by the data from the other family members are eliminated from the individuals' haplotype lists. The remaining haplotypes are then used to determine a sibling's carrier status of the PKU disease, i.e., whether or not a sibling is a carrier of the PKU disease. / Thesis / Master of Science (MS)