Yes

Peptide and protein sequences are most commonly represented as a strings: a series of letters selected from the twenty character alphabet of abbreviations for the naturally occurring amino acids. Here, we experiment with representations of small peptide sequences that incorporate more physiochemical information. Specifically, we develop three different physiochemical representations for a set of roughly 700 HIV–I protease substrates. These different representations are used as input to an array of six different machine learning models which are used to predict whether or not a given peptide is likely to be an acceptable substrate for the protease. Our results show that, in general, higher–dimensional physiochemical representations tend to have better performance than representations incorporating fewer dimensions selected on the basis of high information content. We contend that such representations are more biologically relevant than simple string–based representations and are likely to more accurately capture peptide characteristics that are functionally important. / Singapore-MIT Alliance (SMA)

In order to clarify the effects of a single night of CPAP titration on various cardiovascular, gas exchange, and perceptual measures, we conducted submaximal ramping exercise tests to an intensity of ~75% of the heart rate reserve in five male subjects. Means and standard deviation for their age and BMI were 57.0±14.7 years and 30.5±7.2, respectively. The baseline exercise test was administered immediately after the patients arose from bed, following an overnight PSG diagnostic evaluation. The exercise test was repeated within ~2 weeks of completion of an overnight CPAP evaluation trial. Patients reported experiencing improved sleep quality (50%) after the CPAP titration, based on comparison of morning questionnaire responses from the diagnostic PSG vs. CPAP titration. Statistical significance was not attained (p>0.05) upon analysis of the following parameters at 60% of the individuals maximum workload although there were changes in the mean values of the variables from the diagnostic PSG vs CPAP titration. The following changes were noted: heart rate increased by 6%, systolic blood pressure decreased by 6%, and the rate pressure product decreased by 5.8%. Respiratory variables changed as follows: VO2 decreased by 5.3% and VE decreased by 8.5%. The perceptual measure rate of perceived exertion (RPE) decreased by 17.5%. These preliminary findings demonstrate that self-reports of sleep quality in patients with diagnosed OSA improved after a single night of CPAP titration, even in a setting wherein the total time of CPAP sleep and reduction of apneas, hypopneas, and hypoxemic episodes are highly variable. Additionally, sleep structure revealed a marked increase in slow wave (53.2%) and REM (30.4%) sleep with CPAP titration in comparison to the diagnostic PSG. It was concluded that CPAP titration effectively improves sleep structure and patient ratings of sleep quality, but does not have significant effects on cardiorespiratory responses to submaximal endurance exercise. / Master of Science

No presente estudo, pretendemos realizar uma leitura de Ecce homo balizada pelo procedimento genealógico, pela fisio-psicologia e pela tipologia presentes no pensamento de Nietzsche. Acreditamos que a mudança que se opera no tratamento do humano a partir dessas três noções permite a Nietzsche, em Ecce homo, realizar uma espécie de duplo movimento. Por um lado, o filósofo realiza a máxima afirmação da vida e de si mesmo, dando expressão a uma série de estados afetivos que o constitui. Por outro lado, ao afirmar-se, Nietzsche marca oposição -- e nisso talvez certa transvaloração -- a um estado de coisas marcado pela desvalorização da efetividade. Nossa hipótese é de que podemos ler a obra em questão como sendo a apresentação de um tipo, o \"tipo Nietzsche\". O Nietzsche que se conta em Ecce homo é aquele que se constitui em oposição à moral socrático-platônico-cristã que predomina no ocidente. E mais que isso é um tipo que, segundo o filósofo, possui o pathos filosófico dionisíaco, ou seja, o tipo forte, saudável e que tem como prerrogativa a afirmação da vida. / This study intends to do a reflection of Ecce Homo embossed by the genealogical procedure, by the physio-psychology and the typology present in Nietzsche\'s thought. We believe that the change that takes place in the treatment of the human from these three notions, allows Nietzsche, in Ecce Homo, to do a type of double movement. In one hand, the philosopher reaches the maximum affirmation of life and oneself, giving expression to a series of affectionate states that constitute him. On the other, in affirming himself, Nietzsche marks an opposition - and with that a certain transvaluation - to a state of things marked by the devaluation of effectiveness. Our hypothesis is that we can read this work as being a presentation of a type, the \"Nietzsche type\". That Nietzsche which narrates himself in Ecce Homo is the one that is constituted in opposition to the Socraticplatonic- Christian moral that prevails on the West. Moreover, it\'s a type that, according to the philosopher, owns the Dionysius philosophical pathos, or, the strong type, healthy, that has as its prerogative the affirmation of the life.

Many plants require exposure to low temperature for a certain period during each year. This was determined more than a century ago. Understanding this phenomenon, known as the rest period, is part of a larger problem of understanding the factors which determine the ability of an organism to grow. The property of rest is ultimately a property of the actively growing cells, rather than that of the cells involved with protection and support.

The effects of controlled atmosphere on the metabolism of Golden Delicious and Rome Beauty apples, Anjou pears, and Lambert and Bing cherries were studied with respect to changes caused in the normal metabolic functions carried on during storage of these fruits. Atmospheres consisting of 1.5 per cent CO2 and 2.5 per cent O2 for the apples and pears and 10.5 per cent CO2 and 2.5 per cent O2 for the cherries were employed. Fungi of the strains Botrytis alli, Rhizopus nigricans, and Penicillium expansum were subjected to controlled atmospheres at 21° C to determine the toxic effect of CA. The fungi were grown on agar plates instead of fruit to prevent bias, such as condition of the fruit. Periodically, fruit was taken directly from the storage treatments and analyzed for CO2 evolution, for total and reducing sugars, organic acids, amino acids, and cytochrome c oxidase. Fruits were also taken from the storage treatments and held for a specific time at 15° C before analysis. The CA used in this experiment had an inhibitory effect on the fungi that were used. Botrytis alli and Penicillium expansum were particularly susceptible. It was found the height of the mycelial mat was less, the mycelium growth was less, and while sporulation was not eliminated, it was severely retarded. Combinations of CA and lowered temperatures should attain a high degree of fungal control. The results showed that CA had an inhibitory effect on the metabolic system of stored fruits. The specific areas of metabolic inhibition are not known exactly. This inhibition does not appear to be of a permanent nature as shown by the post storage analysis. Any differences that occurred in the CA stored fruit as contrasted to the fruit from the conventional stored fruit appeared to be able to correct themselves once they were removed from the CA.

No presente estudo, pretendemos realizar uma leitura de Ecce homo balizada pelo procedimento genealógico, pela fisio-psicologia e pela tipologia presentes no pensamento de Nietzsche. Acreditamos que a mudança que se opera no tratamento do humano a partir dessas três noções permite a Nietzsche, em Ecce homo, realizar uma espécie de duplo movimento. Por um lado, o filósofo realiza a máxima afirmação da vida e de si mesmo, dando expressão a uma série de estados afetivos que o constitui. Por outro lado, ao afirmar-se, Nietzsche marca oposição -- e nisso talvez certa transvaloração -- a um estado de coisas marcado pela desvalorização da efetividade. Nossa hipótese é de que podemos ler a obra em questão como sendo a apresentação de um tipo, o \"tipo Nietzsche\". O Nietzsche que se conta em Ecce homo é aquele que se constitui em oposição à moral socrático-platônico-cristã que predomina no ocidente. E mais que isso é um tipo que, segundo o filósofo, possui o pathos filosófico dionisíaco, ou seja, o tipo forte, saudável e que tem como prerrogativa a afirmação da vida. / This study intends to do a reflection of Ecce Homo embossed by the genealogical procedure, by the physio-psychology and the typology present in Nietzsche\'s thought. We believe that the change that takes place in the treatment of the human from these three notions, allows Nietzsche, in Ecce Homo, to do a type of double movement. In one hand, the philosopher reaches the maximum affirmation of life and oneself, giving expression to a series of affectionate states that constitute him. On the other, in affirming himself, Nietzsche marks an opposition - and with that a certain transvaluation - to a state of things marked by the devaluation of effectiveness. Our hypothesis is that we can read this work as being a presentation of a type, the \"Nietzsche type\". That Nietzsche which narrates himself in Ecce Homo is the one that is constituted in opposition to the Socraticplatonic- Christian moral that prevails on the West. Moreover, it\'s a type that, according to the philosopher, owns the Dionysius philosophical pathos, or, the strong type, healthy, that has as its prerogative the affirmation of the life.

The extent and nature of physio-chemical changes that take place in detached leaves after harvest and during storage have been reviewed and discussed by Osborne (1962) and Rogers (1955). These changes include loss of moisture (Wittwer et al., 1962), chlorophyll degredation (Person et al., 1957), Protein loss (Thimann and Manmahan, 1960), and result in subsequent appearance of the visual manifestations of senescence of plant tissues. As lettuce, like most leafy vegetables, deteriorates rapidly and steadily after harvest. Loss of quality is inevitable and can only be minimized by rapid handling and with the best possible storage conditions (Pratt et al., 1954). In recent years, abundant work has been done to delay senescence by the use of various chemicals. Among the investigated chemicals, kinetin (6-furfurylarninopurine) and its related c ompounds show some promise. Van Overbeek et al. (1941) reported a potent new growthpromoting factor (kinetin) in coconut milk. This chemical is active in causing many of the growth reactions of c oconut milk at exceedingly small dosages. Subsequently several arninopurine compounds were synthesized. One of which is SD 4901 (Verdan), N6-benzyladenine, an experimental senescence inhibitor, was developed by Shell Development Company, Modesto, California in 1960. Many reports showed that this chemical is capable of delaying senescence of plant tissues on the basis of restoring protein molecules and respiration inhibition. On the other hand, others have shown stimulation of respiration and delaying of senescence. Paucity of scientific literature on the stability of those chemicals on leafy vegetables gave impetus to a study of the comparative influence of pre- and post-harvest applications of 6-furfurylaminopurine and N6-benzyladenine as related to successive harvest times. Such studies may have considerable economic bearing upon storing and shipping leafy vegetables to distant markets. This thesis presents effects of different concentrations (5, 10, and 20 ppm.) of pre- and post-harvest applications of 6-furfurylaminopurine and N6-benzyladenine as related to three successive harvest times (at one week intervals) on chlorophyll content, moisture content, total nitrogen, insoluble and soluble nitrogen, oxygen uptake, 0 and co2 production during storage (at 40 Fo and 85 percent RH) of "Great Lakes" variety of lettuce.

The post-harvest physiology of sugarbeet (Beta vulgaris) roots was studied during controlled atmosphere (CA) storage at 35° and 50°F. Zero, 3, 6 and 10% carbon dioxide and 5% oxygen concentrations were employed to investigate the most beneficial concentrations of gases. Under the experimental conditions beets were stored successfully for 200 days. The maximum beneficial effects of CA were observed under 6% carbon dioxide and 5% oxygen at 35°F. Regardless of storage temperatures , sucrose retention was highest in the beets stored under CA, compared to conventional refrigeration (CR). Other beneficial effects include less hydrolysis of sucrose to reducing sugars and a decrease in raffinose accumulation. Fungal growth and sprouting were also inhibited significantly, under CA. In the second phase of the studies, investigations were conducted on sugarbeets to study the effects of different levels of nitrogen fertilizer on the optimum CA storage at 40°F. Regardless of the level of nitrogen fertilization, the beets stored under CA demonstrated beneficial effects as described earlier. In addition, respiration, measured on the whole beets, and amino nitrogen content of the beets were lower in the CA-stored beets than those stored under CR. Accumulation of citric acid and succinic acid was significant in the CA-stored beets.

Tyrimo objektas: smulkiosios motorikos ir funkcinio savarankiškumo kaita pirminės reabilitacijos eigoje. Tyrimo problema: kadangi kiekvieno sergančiojo insultu reabilitacija turi skirtingų krypčių poreikius, o literatūroje iki šiol nėra apibrėţtos stratifikacijos ir reabilitacijos programų individualizavimo krypčių, skirtų insulto paţeistos rankos judesių valdymui atgauti (Meldrum, 2004), siekiant efektyviai panaudoti reabilitacijos išteklius, svarbu numatyti galimas ligos baigtis (Milinavičienė ir kt., 2007). Todėl analizavome smulkiosios motorikos atsigavimą pirminės reabilitacijos etape pacientams, patyrusiems išeminį galvos smegenų insultą, siekiant įvardinti nors kelis atskaitos taškus formuojant kineziterapijos artimuosius bei tolimuosius tikslus – retrospektyviai perţiūrint įgyvendintus tikslus, keltus tipiškos funkcinės būklės tiriamųjų grupei – kuriuos matome rezultatų analizėje. Tyrimo tikslas: išanalizuoti ir įvertinti pacientų, patyrusių išeminį galvos smegenų insultą, smulkiosios motorikos atsigavimą bei funkcinio savarankiškumo kaitą, pirminės reabilitacijos eigoje. Tyrimo uţdaviniai: 1. Ištirti ir įvardinti dominuojantį smulkiosios motorikos atsigavimą pirminės reabilitacijos eigoje; 2. Ištirti ir įvertinti pacientų funkcinio savarankiškumo kaitą, pirminės reabilitacijos eigoje; Tyrimo hipotezė: pirminės reabilitacijos etape artimieji bei tolimieji kineziterapijos tikslai turėtų atitikti paciento regeneracinį potencialą, kuris taip pat galėtų būti įvertintas... [toliau žr. visą tekstą] / Study subject: the dynamis of interchange of fine motor and functional independence in the process of the initial rehabilitation. The problem of the study: the rehabilitation of each patient suffering from stroke has different requirements, however, to this date literature does not indicate defined individualisation types of stratification and rehabilitation programmes, assigned to recover the control of stroke affected hand/arm movement (Meldrum, 2004). In order to effectively use rehabilitation resources, it is important to foresee the possible consequences of the disease (Milinavičienė ir kt., 2007). Therefore we analysed the fine motor recovery at the initial rehabilitation stage in the patients who had suffered ischemic head brain stroke. Study aim: to analyse and evaluate patients‘, who had suffered ischemic head brain stroke, the small motor post stroke recovery as well as the change in functional independence in the initial rehabilitation stage. Study goals: 1. To examine and name the dominant fine motor recovery in the initial rehabilitation stage; 2. to examine and evaluate change in patients‘ functional independence in the initial rehabilitation stage; Hypothesis: at the initial rehabilitation stage the short-term and long-term physio-therapeutic goals have to match a patient‘s regenerative potential, which can also be evaluated with reference to the initial functional stage at a patient‘s arrival to hospital. Study methods: Barthel test measuring a patient‘s... [to full text]