In 2006 an historic era of the Supreme Court came to a close with the retirement of its first female justice, Sandra Day O'Connor. This paper attempts to expand judicial behavior scholarship by examining O'Connor's policy preferences for possible ideological change during her twenty-five year tenure on the Court. Average liberalism scores for her overall and civil rights/civil liberties issue area votes show an increase in liberalism over time. The researcher employs time series cross section analysis with panel corrected standard errors to determine factors responsible for this increase. Issue change, interagreement with the other justices, changes in Court membership, ideological mood of the country, and political polarization account for the lion's share of the increase. Contrary to the prevailing attitudinal model, change of preference does occur; however, the issue of separating true preference change from other salient influences in a statistical model remains unresolved.

The thesis provides a comprehensive overview of key issues affecting practice, policy and patients, in current efforts for colorectal cancer (CRC) disease control. The global burden of CRC is expected to increase by 60% to more than 2.2 million new cases and 1.1 million deaths by 2030. CRC incidence and mortality rates vary up to 10-fold worldwide, which is thought to reflect variation in lifestyles, especially diet. Better primary prevention, and more effective early detection, in screening and surveillance, are needed to reduce the number of patients with CRC in future1. The risk factors for CRC development include genetic, behavioural, environmental and socio-economic factors. Changes to surveillance, which offer non-invasive testing and provide primary prevention interventions represent promising opportunities to improve outcomes and personalise care in those at risk of CRC. By systematic review of the literature, I highlight the gaps in comparative effectiveness analyses of post-polypectomy surveillance. Using micro-simulation methods I assess the role of non-invasive, faecal immunochemical testing in surveillance programmes, to optimise post-polypectomy surveillance programmes, and in an accompanying sub-study, I explore the value of adding an adjunct diet and lifestyle intervention. The acceptability of such revisions is exposed to patient preference evaluation by discrete choice experiment methods. These preferences are accompanied by evidence generated from the prospective evaluation of the health literacy, numeracy, sedentary behaviour levels, body mass index (BMI) and information provision about cancer risk factors, to highlight the potential opportunities for personalisation and optimisation of surveillance. Additional analysis examines the optimisation of a screening programme facing colonoscopy constraints, highlighting the attendant potential to reduce costs and save lives within current capacity.