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The present study evaluates the efficacy of self-hypnosis and its components--relaxation instructions and waking analgesia suggestions--for pain reduction in patients recovering from gallbladder surgery. Forty elective surgery patients were randomly assigned to one of the three experimental pain control procedures or to a standard treatment control group--preoperative teaching. The treatments were found to be equally credible and generated equivalent expectancies for success. Pain was assessed using multiple subjective and objective measures sampled across the postoperative period. Multivariate analysis of these data indicated that the experimental treatments were no more effective in diminishing postoperative pain than the control procedure. However, the analysis revealed several significant correlates and predictors of postoperative pain. These included trait anxiety, depression, stress coping style as well as interview and rating scale reports of cognitive coping strategies. Significant predictors of credibility--expectancy, treatment utilization and cognitive coping classifications were also found. Analysis of the pain measurement strategy indicated consistency among the subjective measures--the McGill Pain Questionnaire and visual analogue scales--which were relatively independent from the objective measures, which comprised electronically monitored gross motor activity and analgesic medication requirements. Possible interpretations and implications of these results as well as suggestions for future research are discussed.

This thesis describes applications of mathematical modelling to systems of demand analgesia for the relief of acute postoperative pain. It builds upon work described in the D.Phil. thesis of M.P. Reasbeck. Following major surgery, patients are given a hand-held button which they press when in need of pain relief. The relief is afforded by automatic intravenous infusion of opiates. New clinical demand analgesia hardware, PRODAC, has been developed and data have been collected with it in two major trials involving a total of 80 patients. Patients' drug requirements have been found not to be correlated with body weight, contrary to conventional teaching. The type of operation was also found to have no significant influence upon drug requirements. The performance of transcutaneous nerve stimulation (TNS) as a method of analgesia for acute postoperative pain has been studied and found to be poor. Reasbeck's mathematical model of patients in pain has been corrected and extended. The representation of pharmacokinetics has been enhanced by modelling the transfer of drug between blood plasma and analgesic receptor sites as a first-order process. The time constant of this process has been calculated for morphine using a novel method and found to be 12 minutes. On line estimation of 2nd order pharmacokinetic time constants has been found in simulation not to be feasible. New software has been used to tune the revised model to the clinical data collected with PRODAC. Model behaviour is now demonstrably life-like, which was not previously the case. Blood samples taken during demand analgesia have permitted a comparison between measured and estimated drug concentrations, with good results.

Tez (Tıpta Uzmanlık) - Süleyman Demirel Üniversitesi, Tıp Fakültesi, Anesteziyoloji ve Reanimasyon Anabilim Dalı, 2005. / Bibliyografya var.

Thesis (Ph.D.)--University of Melbourne, Melbourne Dental School, 2009. / Typescript. Includes bibliographical references.

Thesis (M.S.)--University of Michigan, 1979.

Thesis (Ph.D.)--Duquesne University, 2004. / Title from document title page. Abstract included in electronic submission form. Includes bibliographical references (p. 90-97) and index.

Thesis (M.S.)--University of Michigan, 1979.

Thesis (M.N.)--University of Alberta, 2010. / A thesis submitted to the Faculty of Graduate Studies and Research in partial fulfillment of the requirements for the degree of Master of Nursing, Faculty of Nursing. Title from pdf file main screen (viewed on April 22, 2010). Includes bibliographical references.

Thesis (M.S.)--University of Wisconsin-Madison, 1988. / Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 120-125).