Kauno gamybinėse vaistinėse dozuoti milteliai yra dažnai gaminama vaisto forma ir sudaro 11,58 proc. ekstemporalių kartinių vaistų. Miltelių gamyba, pakuojant į popierines kapsules, nėra pakankamai racionali. Pacientų atžvilgiu – tai nesandari laikyti ir nepatogi vartoti vaisto forma, todėl miltelius racionaliau yra pakuoti į kietąsias, skrandyje suyrančias kapsules. Šio darbo tikslas - nustatyti ir įvertinti dažniausiai vaistinėse pasitaikančių miltelių kapsuliavimo sąlygas. Tyrimo objektai yra sudėtiniai milteliai ir jais užpildytos kapsulės. Taikyti tyrimų metodai: miltelių technologinių savybių nustatymo metodai (Carr indeksas, Hausner koeficientas, kūgio kampas), kapsulių masės vienodumo ir stabilumo nustatymo – gravimetriniai metodai. Atrinktos dažniausiai vaistinėse gaminamos ekstemporalių kartinių miltelių sudėtys. Aspkaičiavus papildomus pagalbinių medžiagų kiekius atrinktoms miltelių sudėtims, jie pritaikyti pakuoti į kietąsias skrandyje suyrančias kapsules. Įvertinta papildomos pagalbinės medžiagos kiekio įtaka technologinėms miltelių mišinių savybėms ir dozavimo tikslumui. Atlikti užpildytų kapsulių kokybės ir stabilumo tyrimai stebint kapsulių masės vienodumą, turinio drėgmės kiekį ir kapsulių suirimo laiką. Parinkus dažniausiai vaistinėse gaminamų ekstemporalių kartinių miltelių receptūras, modeliuojant papildomus pagalbinės medžiagos kiekius, miltelių mišinys pritaikytas kapsuliavimui. Naudotos rankinės kapsulių pildymo mašinėlės “Capsuline – 15”, “Capsuline... [toliau žr. visą tekstą] / Powder is often produce drug form in Kaunas industrial pharmacy and consists of 11,58 per cent. Powder manufacture, packing in paper caps are not rational enough. An attitude of patient, this formulation is leaking and inconvenient to use. Powder is more rational packed in solid gastro - soluble capsules. The aim of this research is to set the encapsulation conditions of commonly occurring powder mixtures. The study objects are composite powders and hard gelatin capsules filled them. Research methods have been applied in this study: methods for determining powder technological properties (Carr index, Hausner ratio, angle of reponse), capsule mass uniformity and stability tests. Commonly produced extemporaneous powder mixtures in pharmacies were selected. Estimated an additional content of adjuvant substances for powder compositions and applied to the encapsulation of hard gelatin capsules. Evaluated influence of the estimated content of adjuvant substances on the technological properties of the powder mixture and dosing accuracy. Perform filled capsules quality and stability studies monitoring of moisture content in capsules, mass uniformity and disintegration time of capsules. Modeling of adjuvant substances quantities, powder mixture applied for capsulation. Manual capsule filling machines “Capsuline – 15”, “Capsuline – 60” and semi-automatic capsule filling machine “Feton Fastlock 100” were used. The uniformity of capsules mass and stability studies of produced... [to full text]

Aim: The objective of this project was to use analytical powder decompression (APDC) in tablet compaction processes to study the elastic behavior of powders. Background: During powder compaction, the particles undergo four stages of rearrangement, plastic deformation or particle fracture, and elastic deformation. The analytical powder compression protocol considers the loading phase and the elastic deformation during the unloading phase is neglected (Nordström et al., 2012). Using APDC analysis may give access to the underlying elastic characteristics of powders including tablet elastic recovery and powder modulus of elasticity (Persson et al., 2018). Methods: Two materials with different elasticity properties, NaCl and maize starch, were selected. After standard powder characterization, the powders were used in tablet compaction experiments with various pressures, compression and decompression rates, and lubrication. The resulting powder elastic modulus (EM) and tablet elastic recovery during unloading (ERin-die) and after ejection (ERout-of-die) up to 24 h were evaluated. Results: EM for NaCl was reduced by increased pressure or addition of internal lubrication, but no impact was seen from the compaction speeds. ERin-die for NaCl was doubled by the internal lubrication. For maize starch, EM increased at higher pressure, but it was not affected by the speeds or internal lubrication. ERout-of-die was negligible for NaCl, but it increased for maize starch with time. Conclusion: The larger nonlinear profile during unloading for maize starch can be a sign of mixed elastic and inelastic phenomena. The ascending trend for EM vs pressure for maize starch can be attributed to a larger interparticle cohesion and lower porosity. Addition of internal lubrication to NaCl lowered the tablet strengths which led to extensive relaxation and therefore much larger ERin-die.