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Purpose. The chemistry, pharmacokinetic and pharmacodynamic properties, efficacy, and safety of the recently introduced combination antimicrobial agent ceftolozane-tazobactam are reviewed. Summary. Ceftolozane-tazobactam (Zerbaxa, Cubist Pharmaceuticals) is a cephalosporin β-lactam and β-lactamase inhibitor marketed as a fixed-dose combination agent for the treatment of complicated urinary tract and intraabdominal infections. Its dosing and chemistry provide expansive antimicrobial coverage of gram-negative organisms, including Pseudomonas aeruginosa, and stable activity against many β-lactamases, as well as coverage of most extended-spectrum β-lactamase-producing organisms and some anaerobes. Ceftolozane-tazobactam is susceptible to hydrolysis by carbapenemase enzymes but is not affected by other resistance mechanisms such as efflux pumps and porin loss. Clinical trials demonstrated that combination treatment with ceftolozane-tazobactam plus metronidazole had efficacy comparable to that of levofloxacin in patients with complicated urinary tract infections, including pyelonephritis, and comparable to that of meropenem against complicated intraabdominal infections. A Phase III trial of ceftolozane-tazobactam versus meropenem for treatment of bacterial pneumonia, including ventilator-associated pneumonia, is underway. Adverse effects reported with ceftolozane-tazobactam use are comparable to those seen with other β-lactams (e.g., hypersensitivity, nausea, diarrhea, headache). Initially, ceftolozane-tazobactam may be reserved for targeted therapy against multidrug-resistant pathogens. Conclusion. Ceftolozane-tazobactam is a new cephalosporin with enhanced activity against multidrug-resistant P. aeruginosa and other gram-negative pathogens.

Pain management in the pediatric population is complex for many reasons. Mild pain is usually managed quite well with oral acetaminophen or ibuprofen. Situations involving more severe pain often require the use of an opioid, which may be administered by many different routes, depending on clinical necessity. Acute and chronic disease states, as well as the constantly changing maturational process, produce unique challenges at every level of pediatrics in dosing and management of all medications, especially with regard to high-risk opioids. Although there has been significant progress in the understanding of opioid pharmacokinetics and pharmacodynamics in neonates, infants, children, and adolescents, somewhat limited data exist from which necessary information, concerning the safe and effective use of these agents, may be drawn. The evidence here provided is intended to be helpful in directing the practitioner to patient-specific reasons for preferring one opioid over another. As our knowledge of opioids and their effects has grown, it has become clear that older medications like codeine and meperidine (pethidine) have very limited use in pediatrics. This review provides pharmacokinetic and pharmacodynamic evidence on the currently available opioids: morphine, fentanyl (and derivatives), codeine, meperidine, oxycodone, hydrocodone, hydromorphone, methadone, buprenorphine, butorphanol, nalbuphine, pentazocin, ketobemidone, tramadol, piritramide, naloxone and naltrexone. Morphine, being the most studied opioid analgesic, is the standard against which all others are compared. Pharmacokinetic parameters of morphine that have been found in neonates, i.e., higher volume of distribution, immature metabolic processes that develop at various rates, elimination that is variable based on age and weight, as well as treated and untreated disease processes, are an example of all opioids in the population discussed in this review. Outside the premature and neonatal population, the use of opioids in infants, children, and adolescents quickly begins to resemble the established values found in adults. As such, the concerns (risks) of these medications become comparable to those seen in adults.

Includes bibliographical references. / The following research presents an exploration on the role that competency assessments and competency reports play in child sexual abuse cases. This research is informed by forensic social workers in practice within the Gauteng Province. The respondents work both within government organisations and non-government organisations. This research uses a mixed methodology approach to explore practices around competency assessments and competency reports. The respondents completed two forms of data collection namely a survey and were part of a focus group which was conducted by the researcher. The findings therefore presents both quantitative and qualitative data, and are discussed to further elaborate on practices within the Gauteng Province. Conclusions and recommendations were made by both the researcher and the respondents, which are supported by the findings of this research and existing literature in the field.

Mobile communications have added an ever present layer to our personal communication through which social dynamics can be reconstructed. In youth culture specifically, instant messaging allows young people to achieve limited autonomy, explore peer groups and an evolving sense of self. This dissertation explores a model for understanding how instant messaging facilitates this. Theories of media ecologies provide useful ways of explaining media environments. Nonetheless ecologies are usually conceptualised in relation to mass media rather than networked media and tend to assume that ecologies are situated in a particular physical space. The theory is nonetheless useful in understanding the everyday experience of young people using media. By extending media ecology theory to account for the personal communicative ecologies of instant messaging, this study extends the notion of ecology to account for a sense of digital social space outside the constructs of physical space. Through taking an interactional epistemological stance, qualitative research was conducted. Two focus groups were conducted to explore how instant messaging channels meet the needs of a group of young people from middle class contexts in Cape Town. The resultant discussions are applied to the framework of a 'layered' communicative ecology, taking technology, social and discursive layers into account and establishing the centrality of social space within a new and expanded model of networked messaging ecologies. The central aim of this research is to explore how relevant the application of media ecologies would be to an exploration of digital spaces of communication and practice.

The Voortrekker Road Corridor in Cape Town was recently identified as an Integration Zone according to National Treasury's Integrated City Development Grant (ICDG). Prior to this a number of private and public stakeholders founded the Greater Tygerberg Partnership, in response to the need for a coordinating body to champion inclusive regeneration and local economic development in the corridor and neighbouring northern suburbs. Funded wholly by the City of Cape Town for its first three years of operation, the Partnership had after two years in operation appeared to have made little progress in catalysing interest and tangible investment in the area, even on a micro level. This dissertation utilises the qualitative analysis method of process tracing for the period of 2012-2015 to explore themes of urban governance and conversely urban patronage. It firstly considers whether the apparent stasis is due to the Partnership being subjected to capture by strong private and political elites. Subsequently it examines whether incremental, micro-level governance initiatives and acts of public entrepreneurship, though seemingly small, have the potential to build momentum capable of overcoming such threatening predatory networks, and in so doing redirect the organisation towards achieving substantive inclusive and equitable regeneration.

Many research documents indicate that learners’ ability to transition from education and training to employment is closely linked to their work placement experience during their studies and on exit from their respective qualifications. This study identifies and analyses successful work placement practices through case studies, to understand which elements have supported TVET Colleges to facilitate the successful placement of their learners. The study starts with a historic overview of the Colleges to provide the context. It then moves on to explore, through secondary research, what the literature says about the identified elements which are institutional responsiveness; Work Integrated (WIL) units, curriculum relevance, partnerships and work readiness and their contribution to the transition from education to employment. The literature analysis was used to formulate key research questions for the primary research with three metro TVET Colleges, to explore how these Colleges have responded to the elements identified. The responses from the interviewees were used to extract the learnings from their practice and to draw out the elements that are key contributors to the successful placement of TVET learners.

Includes bibliographical references (74-75). / This creative project offers three stories that explore the value and objectives of animal welfare using the genre of narrative literary journalism. The project required extensive fieldwork specific for each article, as well as the careful analysis of the style and history of narrative literary journalism. I have also written a short essay reflecting on the process of writing these articles which clarified for me the learning curve that I have experienced on this project.

Includes abstract. / Includes bibliographical references. / This research paper uses content analysis to analyse the subtext of Obama's campaign messages and virtual ethnography to analyse the way that information technology was used to further his campaign's goals. The findings suggest that while historic forces, such as economic turbulence and the unpopularity of outgoing President George W Bush, helped propel Obama to power, his campaign was nonetheless revolutionary. It will be argued that it contained several elements of trail blazing innovation that are likely to redefine political communications in the U.S and globally.

Includes bibliographical references. / This study investigates the children's experiences whilst awaiting trial at Dyambu Youth Centre. DYC is the largest Youth Development Centre in the country, which serves involuntary clients. A qualitative research method was used to investigate whether the children in the centre do experience change, or does change come about as a result of other factors? Does staff succeed in transferring their skills and motivation to these children? Do the children feel they belong to DYC whilst awaiting trial? Seeing that a whole range of issues needed to be explored and investigated, interview schedules and focus groups were administered and the children's views about DYC had to be investigated from themselves, their parents, staff, volunteers and probation officers at court, who were responsible for their admission at DYC.