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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Precursor-Directed Biosynthesis of Novel Jadomycins and Expansion of the Jadomycin LibraryDupuis, Stephanie 13 August 2010 (has links)
Jadomycins are secondary metabolites produced by Streptomyces venezuelae ISP5230 VS1099 in response to conditions of stress such as heat or ethanol shock. They have been shown to exhibit antibiotic and anticancer activity. Unique structural features of the jadomycins include a rare 2,6-dideoxysugar, L-digitoxose, and an oxazolone ring with an amino acid component. Previous studies have revealed that jadomycin derivatives can be produced by altering the amino acid in S. venezuelae ISP5230 VS1099 culture media which becomes incorporated into the oxazolone ring. One jadomycin from a proteogenic amino acid and three new jadomycins from non-proteogenic amino acids have been successfully produced on a large scale (4 mg/L to 12 mg/L, 2 L) and characterized using mass spectrometry, infrared spectroscopy, UV-visible spectroscopy, and nuclear magnetic resonance spectroscopy. One of these contains a terminal alkyne functionality and has been used in cycloaddition reactions with various azides to produce a library of triazole-containing jadomycins.
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Beiträge zur Biosynthese von Strobilurin A und Oudemansin A sowie Gewinnung neuer halogenierter Strobilurine durch vorläufer-dirigierte Biosynthese / Contributions to the biosynthesis of strobilurin A and oudemansin A as well as extraction of new halogenated strobilurins by precursor-directed biosynthesisThormann, Gerald 26 January 2005 (has links)
No description available.
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Untersuchungen zur Wirkstoffproduktion extremophiler Mikroorganismen sowie Biosynthese und Derivatisierung ausgewählter mikrobieller Naturstoffe / Investigations on the Production of Bioactive Metabolites by Extremophilic Microorganisms as well as Biosynthesis and Derivatization of Selected Microbial Natural ProductsKubicek-Pejic, Adrijana 31 October 2007 (has links)
No description available.
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Beiträge zur Biosynthese der antiparasitären Naturstoffe Hormaomycin und Borrelidin sowie Strukturaufklärung von Sekundärmetaboliten aus Actinomyceten / Studies towards the biosynthesis of the antiparasitic agents hormaomycin and borrelidin and structure elucidation of secondary metabolites from actinomycetesRadzom, Markus 05 July 2006 (has links)
No description available.
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