Thesis (Ph. D.)--University of California, San Diego and San Diego State University, 2002. / Vita. Includes bibliographical references (leaves 94-106).

Maternal consumption of alcohol during pregnancy can induce a range of behavioral and cognitive deficits in offspring, which are collectively termed Fetal Alcohol Spectrum Disorders (FASD). There are significant delays in motor development and sensory-motor skills in children with FASD, but the underlying neurobiological mechanisms of these deficits are poorly understood. The goal of this research project is to test the hypothesis that the Kinesiological Instrument for Normal and Altered Reaching Movements (KINARM) will serve as an effective tool for identifying and measuring specific, neurologically-based motor deficits in children with FASD. These deficits were revealed through investigation of multi-joint upper limb movements during the performance of sensory-motor tasks. Children (31 FASD; 83 controls, aged 5 to 18 years, male and female) performed: (1) a visually-guided reaching task with fingertip feedback only; and children (31 FASD; 49 controls, aged 5 to 18 years, male and female) performed: (2) an arm position-matching task in the absence of visual feedback. Children with FASD differed significantly from controls in many reaching task outcome measures, specifically those related to the initial motor response and corrective responses. In particular, large effect sizes were observed for outcome measures related to the first (initial) movement (corresponding to feedforward control; e.g., direction error; distance error), as well as for those measures related to corrective responses (corresponding to feedback control; e.g., difference between minimum and maximum hand speeds; number of speed peaks during movement). In the position-matching task, children with FASD constricted the spatial workspace of the subject-controlled arm relative to the robot-controlled arm, in the horizontal axis. There was also observed a systematic shift between the subject- and robot-controlled arms in the XY end position, resulting in significant error. Additionally, children with FASD exhibited significantly increased trial-to-trial variability for final hand position of the subject-controlled arm, over all targets, and for which large effect sizes were observed. The results suggest that children with FASD have difficulty integrating sensory information into planned motor movements. The KINARM is a promising research tool that may be used to assess motor control deficits in children affected by prenatal exposure to alcohol. / Thesis (Master, Neuroscience Studies) -- Queen's University, 2010-09-02 15:10:25.653

The cognitive and/or behavioural problems associated with Fetal Alcohol Spectrum Disorder (FASD) place this population at increased risk of involvement in the justice system. Although FASD poses challenges at each stage of the justice system, legal discussion and commentary have pinpointed the sentencing stage as the phase in which the issue of FASD is most commonly raised and considered. The purpose of this study is to examine if (and how) FASD is being taking into consideration at sentencing. To this end, a comparative analysis of 87 sentencing judgments (42 FASD offenders and 45 non-FASD offenders) reported in Quicklaw was conducted. Cases were matched on most serious offence (assault, robbery and sexual assault) and jurisdiction (Yukon, British Columbia and Ontario). Descriptions of FASD and non-FASD offenders as reported by judges were found to differ in a number of significant ways. Similarly, sentencing purposes applied to each offender group emerged as distinct. Despite these distinctions, no differences were found in the type and length of sentence handed down (even after controlling for criminal record and breaches). These findings indicate a need for further research and possible policy changes.

The objective of the present study was to examine the effects of prenatal exposure to alcohol on sensorimotor coordination, emotionality, learning and memory in young adult Wistar rats. Most of the recent reports concerning behavioral effects of fetal alcohol exposure refer to the juvenile period of life and very few studies investigated different aspects of behavior simultaneously in the same subjects. In the current study, alcohol was delivered to the pregnant dams by intragastric infusions, throughout gestation days (GD) 7-20, at the dose of 6g /kg maternal body weight /day. This dose resulted in relatively high peak blood alcohol concentration (340 mg/dl) as assessed on GD 20. A pair-fed isocaloric and untreated control groups were included. Prenatal alcohol administration retarded dams&rsquo / weight gain significantly, and had an adverse effect on pups&rsquo / weight at birth but not in adulthood. No between-group differences were observed in the litter size and in the pups&rsquo / mortality. The adult brain weight was neither affected. Pups were subjected to a series of behavioural tests as young adults (at 2.5 months of age). In adulthood, rats prenatally treated with alcohol were not impaired in sensorimotor coordination and/or did not show muscle weakness as assessed by rotarod/accelerod tests. Their behavior in the open field and plus maze suggested alcohol-induced increase in iv anxiety level and some decrease in behavioral flexibility, but hyperactivity was not observed. In cognitive tasks, alcohol treated rats showed slightly slower rate of initial place learning in the water maze. However, memory retention tested after 1 and 10-day delay, reversal learning, rate of extinction of place preference, as well as working memory capacity appeared to be the same in alcohol exposed and control rats. The possible reasons of this negative result are discussed.

Thesis (Ph. D.)--University of California, San Diego and San Diego State University, 2009. / Title from first page of PDF file (viewed June 16, 2009). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 109-134).

Thesis (Ph. D.)--University of California, San Diego, 2000. / Vita. Includes bibliographical references (leaves 151-168).

Thesis (Ed.D.)--University of West Florida, 2005. / Title from title page of source document. Document formatted into pages; contains 218 pages. Includes bibliographical references.

The cognitive and/or behavioural problems associated with Fetal Alcohol Spectrum Disorder (FASD) place this population at increased risk of involvement in the justice system. Although FASD poses challenges at each stage of the justice system, legal discussion and commentary have pinpointed the sentencing stage as the phase in which the issue of FASD is most commonly raised and considered. The purpose of this study is to examine if (and how) FASD is being taking into consideration at sentencing. To this end, a comparative analysis of 87 sentencing judgments (42 FASD offenders and 45 non-FASD offenders) reported in Quicklaw was conducted. Cases were matched on most serious offence (assault, robbery and sexual assault) and jurisdiction (Yukon, British Columbia and Ontario). Descriptions of FASD and non-FASD offenders as reported by judges were found to differ in a number of significant ways. Similarly, sentencing purposes applied to each offender group emerged as distinct. Despite these distinctions, no differences were found in the type and length of sentence handed down (even after controlling for criminal record and breaches). These findings indicate a need for further research and possible policy changes.

Maternal consumption of ethanol during pregnancy contributes to a set of pathologies, grouped together as the fetal alcohol spectrum disorders, affecting as many as 5% of live births in the United States annually. Ethanol acts widely in the developing embryo, affecting many tissues, but causing deficits in neuronal and neural crest populations particularly. These deleterious effects cause archetypical craniofacial expression and neurological deficits, including microcephaly and neuronal dysfunction. Severity of symptoms is linked to frequency of maternal alcohol consumption as well as the maximum blood alcohol concentration reached by the mother. The teratology of ethanol has been widely researched over the last four decades, with the link between the neural crest pathology and the fetal alcohol spectrum phenotype becoming clearer. Animal model studies have managed to replicate many of the symptoms seen in humans afflicted with fetal alcohol spectrum disorders, and have allowed us to elucidate the biochemical mechanisms behind the disease. There is no singular pathway responsible for the fetal alcohol spectrum disorders: over half a dozen models of dysfunction have been identified, and ethanol’s ability to react with a series of targets means that more pathways are likely to be discovered. Current theories regarding the effects of ethanol on the neural crest have implicated apoptosis of the cephalic neural crest, mediated by G-protein coupled receptors, activation of a phospholipase C pathway, and subsequent release of intracellular calcium; perturbations of the actin cytoskeleton leading to migration dysfunction of neural crest cells in the developing neural tube; lack of functional trophic molecules, specifically Shh, likely due to dysfunction of the cholesterol biosynthetic pathway; lack of retinoic acid production; oxidative stress, production of reactive oxygen species, and iron dysregulation; and genetics, which seems to confer greater susceptibility and resistance to ethanol in certain individuals. Ultimately, a global model for ethanol’s actions on the developing fetus eludes researchers, as do any potential treatments, and more research is required to further elucidate ethanol’s teratogenic mechanism.

Background: Pregnancy substance use is linked to low birth weight. However, less is known about relative contributions of various substances and whether effects are due to decreased gestational duration, restriction of fetal growth, or both. The study goal was to use causal modeling to evaluate the individual impact of alcohol, tobacco, cocaine, and marijuana on gestational duration and fetal growth. Methods: Participants were 3164 urban black women recruited at entry to prenatal care and followed to delivery, with all gestational dating ultrasound supported. Pregnancy substance use was assessed via self-report (alcohol, tobacco, cocaine, and marijuana). Results: Alcohol, cigarette, and cocaine use were all individually and negatively related to gestational age at delivery. However, only alcohol, cigarette, and marijuana use predicted fetal growth, with effects for alcohol and cigarette greater and more discrepant for older women. Overall, heavy cigarette smoking had the greatest individual impact on birth weight (up to 431 g). Heavy levels of use of all 4 substances by older women decreased birth weight by 26% (806 g). Conclusions: For perhaps the first time, reduced birth weight is apportioned both by type of substance and mechanism of effect. The use of alcohol and/or cigarettes was clearly more harmful to fetal growth than cocaine use. Findings demonstrate the need for continued emphasis on intervention efforts to address legal and illicit pregnancy substance use.