The repetitive ballistic movements in highland dancing, which occur at more than 100 beats/min while the dancers try to reach a maximal vertical height with each jump, could possibly develop chronic injuries similar to ballet and aerobic dance. This study aimed to determine the following: number of injuries/dancer, number of injuries/100 hours of training, the number of chronic injuries compared to acute, anatomical location of the injuries and possible predictors for sustaining an injury in highland dancers. The 76 participants, aged 7 through 22, were from two Saskatoon Dance Schools. The information was collected by retrospective and prospective questionnaires and data analyzed using a Chi-square, analysis of variance and a binary logistic regression. The six-month retrospective survey found a total of 6 dance-related injuries compared to the 42 dance-related injuries in the four-month prospective questionnaire. When analyzing only the injured dancers the CHD (competitive) had 1.62 injuries/dancer, RHD (recreational) had 1.86 injuries/dancer and the Control group (non-highland dancers) had 2.0 injuries/dancer. Significant differences were not found for the number of injuries sustained in these three dance groups (X2 = 0.72, p<0.70). The injury rate per 100 hours of training for only the injured dancers in each group was as follows; CHD 2.59 injuries/100 hours, RHD 4.51 injuries/100 hours and the Control group 4.97 injuries/100 hours. The majority of the chronic versus acute injuries were sustained by the CHD (9 chronic, 8 acute), however they were not statistically different from the RHD (4 chronic, 7 acute) (X2 = 0.738, p<0.05). Most of the injuries occurred to the lower leg, with the knee, shins/calf, ankles and the feet as the major sites. Significant differences were found for these four lower leg sites versus the rest of the body (X2 = 11.20, p<0.05). There were also no differences for the number of lower leg injuries between the CHD and RHD (X2 = 4.605, p<0.05). The three variables associated with an increased risk for sustaining an injury were age, having a previous injury and the onset of menarche.

The repetitive ballistic movements in highland dancing, which occur at more than 100 beats/min while the dancers try to reach a maximal vertical height with each jump, could possibly develop chronic injuries similar to ballet and aerobic dance. This study aimed to determine the following: number of injuries/dancer, number of injuries/100 hours of training, the number of chronic injuries compared to acute, anatomical location of the injuries and possible predictors for sustaining an injury in highland dancers. The 76 participants, aged 7 through 22, were from two Saskatoon Dance Schools. The information was collected by retrospective and prospective questionnaires and data analyzed using a Chi-square, analysis of variance and a binary logistic regression. The six-month retrospective survey found a total of 6 dance-related injuries compared to the 42 dance-related injuries in the four-month prospective questionnaire. When analyzing only the injured dancers the CHD (competitive) had 1.62 injuries/dancer, RHD (recreational) had 1.86 injuries/dancer and the Control group (non-highland dancers) had 2.0 injuries/dancer. Significant differences were not found for the number of injuries sustained in these three dance groups (X2 = 0.72, p<0.70). The injury rate per 100 hours of training for only the injured dancers in each group was as follows; CHD 2.59 injuries/100 hours, RHD 4.51 injuries/100 hours and the Control group 4.97 injuries/100 hours. The majority of the chronic versus acute injuries were sustained by the CHD (9 chronic, 8 acute), however they were not statistically different from the RHD (4 chronic, 7 acute) (X2 = 0.738, p<0.05). Most of the injuries occurred to the lower leg, with the knee, shins/calf, ankles and the feet as the major sites. Significant differences were found for these four lower leg sites versus the rest of the body (X2 = 11.20, p<0.05). There were also no differences for the number of lower leg injuries between the CHD and RHD (X2 = 4.605, p<0.05). The three variables associated with an increased risk for sustaining an injury were age, having a previous injury and the onset of menarche.

INTRODUCTION: Several studies identified a link between gastroesophageal reflux disease (GERD) and obstructive sleep apnea (OSA). GERD is a condition in which acid reflux from the stomach to the esophagus causes troublesome symptoms. On the other hand, OSA is defined as a sleep-related breathing disorder in which airflow significantly decreases or ceases due to upper airway obstruction, leading to arousal from sleep. OSA was found to be associated with GERD. In this study, we aim to study the characteristics and concurrent risk factors associated with GERD and OSA in a large population-based study. METHODS: Patients with the diagnosis of GERD were extracted from the National Inpatient Database (NIS) for the years 2016 to 2019. Patients' age, gender, race, and hospital information, including region and bed size, were extracted and considered as baseline characteristics. The comorbidities included are hypertension (HTN), atrial fibrillation (AFib), congestive heart failure (CHF), chronic obstructive pulmonary disease (COPD), pulmonary hypertension (PHTN), obesity, and smoking. Patients younger than 18 years old were excluded from this study. Results: Out of 22,677,620 patients with the diagnosis of GERD, 12.21% had a concurrent diagnosis of OSA (compared to 4.79% in patients without GERD, p-value <0.001). The mean age of patients with GERD and OSA was 64.47 years vs 65.42 years in patients without OSA (p-value <0.001). The GERD and OSA group had almost identical gender distribution compared to the GERD only group, as it was predominantly female patients. The white and black races were slightly more prevalent in the GERD and OSA group compared to the GERD only group. Regarding comorbidities, the prevalence of obesity was more clear in the GERD and OSA group. It was noted that the group of patients who carry a diagnosis of GERD and OSA have more prevalence of diabetes (DM), hypertension (HTN), obesity, atrial fibrillation (Afib), congestive heart failure (CHF), and pulmonary hypertension (PHTN). Patients with GERD and OSA were 21% less likely to be older than 65 years rather than younger (95% CI: 0.79-0.8, p-value <0.001), 35% less likely to be females (95% CI: 0.65-0.65, p-value <0.001), and 22% less likely to be non-white (95% CI: 0.77-0.8, p-value <0.001). Obesity was found to be the strongest association with this population, followed by PHTN, CHF, DM, HTN, Afib, and lastly smoking. CONCLUSION: Patients with GERD and OSA were found more likely to be female, white, living in the southern part of the United States, obese, diabetes mellitus type 2, and being active smokers.

Background Better understanding of the demographic distribution of epilepsy and the prevalence of 'more specific forms of epilepsy' in community-based settings would improve our understanding of this disorder at the population level . Although we now have good estimates of epilepsy prevalence for most countries, we still lack knowledge on its demographic distribution by age, ethnicity, region, and socioeconomic status. In addition, no studies to date have reported the prevalence of epilepsy syndromes using patient interview outside a hospital setting. This thesis provides the first community-based estimates of the prevalence of the most common clinical group of epilepsies presumed to have a genetic basis - The Idiopathic Generalised Epilepsies (IGE) - by patient and witness interview. Methods This thesis has involved conducting five pieces of new research: (i) a series of reviews and analyses of descriptive data on epilepsy prevalence, particularly focusing on the critical methodological issues of ascertainment, diagnosis and classification of epilepsy for epidemiological purposes; (ii) the validation of a modified diagnostic epilepsy questionnaire adapted for administration in population studies; (iii) recruitment of a community-based cohort - The Tasmanian Epilepsy Register (TER) - through the Australian national prescription database; (iv) estimation of the overall prevalence and distribution of self-reported treated epilepsy in Tasmania by imputation methods; (v) estimation of the prevalence and distribution of IGE in Tasmania by telephone interviewing. Results My modified diagnostic questionnaire, administered by telephone interviewing and interpreted with standardized guidelines, demonstrated excellent agreement with an epilepsy specialist's clinical assessment in diagnosing the presence of epilepsy (K = 0.94), seizure-onset types (K = 0.84), simple or complex partial seizures (K=0. 87), any generalized non-convulsive seizure (K=0.82), and IGE (K = 0.82). A lthough stil l substantial, agreement was not as close for secondarily general ized seizures (K = 0.74), and generalized tonic-clonic seizures (K = 0.79). 7541 patients treated with antiepileptic drugs (AEDs) in the preceding year in Tasman ia were eligible for recruitment through the Australian national prescription database. After three mail contacts, 54.0% responded, with 43.6% who indicated treatment for epilepsy representing 86.0% of total possible epilepsy cases by imputation (n=2063) in Tasmania. 1180 agreed to participate in the TER, 90.0% of participants received their AEDs either exclusively from their general practitioner (70.9%) or in combination with a medical specialist (19.1%) in the preceding twelve months. The adjusted treated epilepsy prevalence was 4.36 per 1000 (95% CI 4.34, 4.39); this was: lower in women (prevalence ratio 0.92 (95% CI 0.84, 1.00); greater with increasing age (p< 0.001 ); similar in the three main geographical regions; and similar by categories of socioeconomic status based on postcode of residence. Following enrolment, 959/1083 (88.6%) eligible TER participants completed the diagnostic telephone interviewing, with partial epilepsy classified in two thirds, and generalised epilepsy in slightly more than one-fifth. IGE was observed in 20.3%, with tonic-clonic seizures (17.03%) and the absence epilepsies combined (11.01 %) being the most common IGE seizure types and syndromes respectively. The estimated prevalence of IGE was 0.89 per 1000; is highest between the ages of 20-39 years and in females, but was similar between Tasmanian regions and socio-economic groups. IGE prevalence beyond childhood related to refractory childhood or adolescent disease rather than olderonset cases, and was characterised by the presence of myoclonic and tonic-clonic seizures. Generalised seizures, but not IGE, were less prevalent in southern Tasmania. Conclusions Utilising the design approach described in this thesis may provide an alternative to neurological assessment, and when coupled with case ascertainment through prescription data, can provide a valid estimate of the prevalence of 'more specific forms of epilepsy' in countries with high access to health services. The observed pattern of high elderly epilepsy prevalence, is similar to patterns in recent studies in other developed countries, and has important implications for future planning of health services in these countries. IGE represents a considerable proportion of community-treated disease with important aetiological and prognostic determinants occurring at the seizure rather than syndrome level of classification.

Background Better understanding of the demographic distribution of epilepsy and the prevalence of 'more specific forms of epilepsy' in community-based settings would improve our understanding of this disorder at the population level . Although we now have good estimates of epilepsy prevalence for most countries, we still lack knowledge on its demographic distribution by age, ethnicity, region, and socioeconomic status. In addition, no studies to date have reported the prevalence of epilepsy syndromes using patient interview outside a hospital setting. This thesis provides the first community-based estimates of the prevalence of the most common clinical group of epilepsies presumed to have a genetic basis - The Idiopathic Generalised Epilepsies (IGE) - by patient and witness interview. Methods This thesis has involved conducting five pieces of new research: (i) a series of reviews and analyses of descriptive data on epilepsy prevalence, particularly focusing on the critical methodological issues of ascertainment, diagnosis and classification of epilepsy for epidemiological purposes; (ii) the validation of a modified diagnostic epilepsy questionnaire adapted for administration in population studies; (iii) recruitment of a community-based cohort - The Tasmanian Epilepsy Register (TER) - through the Australian national prescription database; (iv) estimation of the overall prevalence and distribution of self-reported treated epilepsy in Tasmania by imputation methods; (v) estimation of the prevalence and distribution of IGE in Tasmania by telephone interviewing. Results My modified diagnostic questionnaire, administered by telephone interviewing and interpreted with standardized guidelines, demonstrated excellent agreement with an epilepsy specialist's clinical assessment in diagnosing the presence of epilepsy (K = 0.94), seizure-onset types (K = 0.84), simple or complex partial seizures (K=0. 87), any generalized non-convulsive seizure (K=0.82), and IGE (K = 0.82). A lthough stil l substantial, agreement was not as close for secondarily general ized seizures (K = 0.74), and generalized tonic-clonic seizures (K = 0.79). 7541 patients treated with antiepileptic drugs (AEDs) in the preceding year in Tasman ia were eligible for recruitment through the Australian national prescription database. After three mail contacts, 54.0% responded, with 43.6% who indicated treatment for epilepsy representing 86.0% of total possible epilepsy cases by imputation (n=2063) in Tasmania. 1180 agreed to participate in the TER, 90.0% of participants received their AEDs either exclusively from their general practitioner (70.9%) or in combination with a medical specialist (19.1%) in the preceding twelve months. The adjusted treated epilepsy prevalence was 4.36 per 1000 (95% CI 4.34, 4.39); this was: lower in women (prevalence ratio 0.92 (95% CI 0.84, 1.00); greater with increasing age (p< 0.001 ); similar in the three main geographical regions; and similar by categories of socioeconomic status based on postcode of residence. Following enrolment, 959/1083 (88.6%) eligible TER participants completed the diagnostic telephone interviewing, with partial epilepsy classified in two thirds, and generalised epilepsy in slightly more than one-fifth. IGE was observed in 20.3%, with tonic-clonic seizures (17.03%) and the absence epilepsies combined (11.01 %) being the most common IGE seizure types and syndromes respectively. The estimated prevalence of IGE was 0.89 per 1000; is highest between the ages of 20-39 years and in females, but was similar between Tasmanian regions and socio-economic groups. IGE prevalence beyond childhood related to refractory childhood or adolescent disease rather than olderonset cases, and was characterised by the presence of myoclonic and tonic-clonic seizures. Generalised seizures, but not IGE, were less prevalent in southern Tasmania. Conclusions Utilising the design approach described in this thesis may provide an alternative to neurological assessment, and when coupled with case ascertainment through prescription data, can provide a valid estimate of the prevalence of 'more specific forms of epilepsy' in countries with high access to health services. The observed pattern of high elderly epilepsy prevalence, is similar to patterns in recent studies in other developed countries, and has important implications for future planning of health services in these countries. IGE represents a considerable proportion of community-treated disease with important aetiological and prognostic determinants occurring at the seizure rather than syndrome level of classification.