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Development of an in vivo animal model for testing of endodontic medicaments on pulp tissueLee, Chun-kei., 李鎮基. January 2001 (has links)
published_or_final_version / Dentistry / Master / Master of Dental Surgery
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Local impacts of large investmentsLindgren, Urban January 1997 (has links)
The aim of the thesis is to investigate local impacts of large investments. This problem has been approached from three directions and, therefore, the study consists of three themes, namely: the changing spatial patterns of corporate activities, the short-term local economic impacts of investments, and the long-term socio-economic impacts of investments on the local municipality. In order to put the impact studies of investments into a broader context the first theme provides an analysis of the macro-orientated processes that change the spatial pattern of a forest- based industry. The empirical investigation is based on a case-study of a major Swedish forest company (SCA — Svenska Cellulosa Aktiebolaget), analysing its development from the 1950s to the present (Paper I). The locational changes of production plants, sales units and headquarters have been mapped and, parallel to this study of the company's spatial evolution, the underlying corporate strategies are discussed. The second theme focuses on the short-term local economic impacts of investments which are carried out at production units. The empirical data has been collected from a major investment introducing a new technology (Light Weight Coated paper - LWC) at Ortviken, an SCA-owned paper mill in Sundsvall. The point of departure for the analysis is the identification of contracted suppliers and their location in order to obtain a picture of the investment's diffusion in the local economy. As the choice of supplier is an important part of the study, criteria on how suppliers are chosen have also been examined (Paper II). Moreover, by using results from a number of similar investment studies, an attempt is made to summarize general experiences within a tentative model for estimating the share of local purchase deriving from major investments: the Local or Non-Local (LNL) model (Paper III). The third theme of the thesis pinpoints long-term local impacts of large investments. The investment generates impacts not only concurrently with the implementation phase, but also during the operation period of the invested item. The investigation of long-term socio-economic impacts has been performed by two studies employing different methodological approaches. The first study (Paper IV) deals with ex ante local impacts of locating a nuclear waste repository in Storuman or Mala, two sparsely populated municipalities in northern Sweden. The model is a traditional macro- formulated cohort model which is combined with a 'basic/non-basic' assumption regarding the intcrdependency within the local trade and business. The second study (Paper V) refers once again to the forest-based industry by emphasising the long-term socio-economic impacts of the investment examined in Paper II. This paper employs a micro-analytical modelling approach, so that, the municipal population is represented individually within the model. A microsimulation model is elaborated in order to analyse the long-term (15 years) local population and labour market dynamics induced by the LWC-investment. Some major findings of the thesis are: * The share of local purchase is connected to the composition of the investment. Analyses have shown that the higher the technological demand and the more technically advanced the goods and services related to the investment, the smaller is the local share of the purchase. * It has proved possible to trace chain effects on different local labour-markets induced by changes in production at a particular place of work. Through linkages between the partial labour markets the closure of a major place of work will not only affect the occupational groups to which laid-off employees belong, but also give rise to changes in unemployment levels in many other occupations. / digitalisering@umu
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Comparison of time taken and breakage of six different endodontic systems to prepare molar teeth.Brittain, Roger January 2006 (has links)
The purpose of this study was to determine duration time, breakage and apical displacement, whilst using six different endodontic filing systems to prepare molar teeth. A total of 96 molar teeth were used in the study, divided equally, ie 16 teeth per system selected randomly, totalling 48 canals per system. A standardised access cavity was prepared for all the teeth before selection. The canals were filed according to the manufacturers&rsquo / guidelines. The result showed that PROTAPER® / , K3&trade / and the combination of: HERO Shaper® / , HERO Apical® / and Endoflare® / (Referred from hereon as HERO System for convenience) were statistically faster than PROFILE® / and FlexMaster® / , which were in turn faster than AETTM. Although breakage did occur in K3&trade / and HERO System this was not deemed statistically significant. Apical displacement occurred in the form of Type 1 in the AETTM, PROFILE® / and HERO System, but once again this was not statistically significant. It was concluded that more aggressive cutting features such as a positive rake<br />
angle, pyramidal shaped tip, progressive taper and absence of radial lands, if present, could have enabled K3&trade / , HERO System and PROTAPER® / to have faster times, and in addition these features did not compromise these systems with regard to apical foramina transportation and breakage.
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Application of water pinch to an integrated pulp and paper Kraft mill with an already highly closed water system.January 2009 (has links)
Sappi's Ngodwana integrated Kraft pulp and paper mill was used as case study for the application and
evaluation of the water pinch technique. The technique of water pinch originates from energy pinch, but
uses mass flow and contaminant concentration to identify water and effluent reduction opportunities.
The classical meaning of pinch, as defmed by energy pinch has however been changed to a more
modem meaning. Historically the terms water or energy pinch was used to refer to the points where two
composite curves touched on energy or water graphs. This graphical meaning of pinch is gradually
being replaced to refer to the optimal po int proposed by a numerical solver beyond which improvement
of the water network is no longer possible for the given inputs. The water pinch technique was applied
by means of a numerical solver that used mixed integer non-linear programming to optimise to the
minimum cost for running the water network under investigation. The problem defmition was defined
in terms of costs associated with the use of utilities, raw material, treatment facilities and process units.
It was also possible to define factors such as environmental impact, corrosion, fouling, scaling, cooling
tower treatment cost, legal risk etc in terms of a penalty cost. The water pinch technique has been
refined in software packages that are user friendly, ca~ble of handling multi-contaminants and suitable
for varying flows. The software package WaterPinch by Linnhoff March was used. The case study
was applied on Ngodwana mill that has an already highly closed water system with effluent generation
rates as low 20 kL per ton of pulp and paper. The pinch study included sodium, chloride, calcium,
suspended solids and COD as contaminants. The study investigated different applications of the pinch
technique. The following was concluded:
• The mill's understanding of its current restrictions, ()l pinch points, of its water network was
confirmed. No new pinch points have been identified of which the mill was not aware. This
indicates that the mill was already highly knowledgeable about its water system. This was expected
of a mill that has a very low specific-effluent-generation rate. Water pinch was unable to
significantly improve on the effluent generation rate of the mill.
• The pinch analysis has identified opportunities of mixing small quantities of waste streams into
process water streams to replace fresh water. These changes can introduce minor water savings and
new risks to the process that have to be understood better before implementation.
• The mill has progressed far with the design and costing of a proposed effluent treatment plant
(ERPl). The integration of this treatment plant into the water network was investigated using the
pinch technique. The pinch solver suggested a totally different approach to the integration of the
ERPI plant compared to design of the mill. The mill's design revolves around the treatment of low
chloride streams in the ERPl plant and using of the treated water as make-up to the cooling towers.
Sodium was recovered as raw material from the cooling towers' blow-down. Pinch proposed
treatment of the high cWoride containing streams and returning the streams to users suitable of using
high chloride water. The network proposed by mill's design generates 8.2 MLlday effluent less
than the pinch proposal, and recovers sodium as raw material. The proposal presented by pinch is
not recommended and points to the difficulty in simulating factors, such as raw material recovery, in
a pinch analysis.
• Users for the excess storm water were identified using water pinch and will be suitable for
implementation. The mill has mwever decided on alternative sinks for the storm water based on
considerations such as process inter-dependency, risks associated with contamination and general
management philosophy for the different systems in the mill. These considerations could have been
included into the pinch solver, but were not because it was of interest what the second best option
would be.
• The pinch investigation proved useful to confirm certain understandings of the mill. The
investigation confirmed the difficulty of improving the water systems of the mill due to the fact that
Ngodwana is already a highly closed and integrated mill. Numerous smaller process changes have been identified by the pinch solver and could be investigated further for smaller process
improvements.
• It i; recommended that pinch technology be applied again when the mill plans to make major
process changes or expansions. It is also recommended to use water pinch on a more frequent basis
in smaller sections of the mill or for other evaluations in the mill. As a group Sappi could benefit
from the use of water pinch, especially in situations where the water network of the mill is not
already water efficient.
• The recommendations and conclusions in this report have not been subjected to technical and
economical feasibility studies. Extensive further studies must be conducted before implementation
of any of the results. Further studies must include impacts from process dynamics, long term
effects, impacts from other contaminants that have not been simulated, etc. / Thesis (M.Sc.Eng.)-University of KwaZulu-Natal, Durban, 2009.
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Simultaneous neutral sulphite semichemical pulping of hardwood and softwood.Antonides, Floris. January 2000 (has links)
The work described in this thesis was aimed at obtaining a better understanding of the neutral sulphite
semichemical pulping process employed by Mondi Kraft's Piet Retief mill, and to investigate ways to
improve this process. The unique feature of the process in this mill is that hardwood and softwood
species are pulped simultaneously in a continuous digester. The pulping trials described were carried
out in a laboratory batch digester which was build as a part of this project. Pulps were evaluated for
yield, Hypo number as an indication of the residual lignin content and strength properties. The first
part of the experimental work focused on the effect that different pulping variables have on the process
and the resulting pulp. Variables investigated were the chemical charge, pulping temperature, chip
composition and anthraquinone dosage. The second part of the work was to investigate ways in which
the process can be improved. In particular it was investigated whether it would be advantageous to
pulp hardwood and softwood separately and mix the two pulps together after pulping. The effect of
changing to an alkaline sulphite process was also briefly investigated.
It was found that the current process is optimized as far as the chemical charge and pulping temperature
is concerned. Increasing the softwood percentage used to 50 % (from current value of 41 %) increases
the tear strength, whilst decreasing it to 30 % increases the tensile strength of the resulting pulp. It was
also determined that increasing the AQ dosage from 0.1 % to 0.5 % might bring savings in chemical
costs. It is suggested that this is investigated in a mill trial.
It was further found that pulping the two species separately improves the tear strength of the pulp by
about 20 % compared with that which was pulped simultaneously. The results indicate that no benefits
concerning the chemical costs, pulping temperature, pulp yield, burst strength or tensile strength are to
be gained from separate pulping.
Preliminary results indicated that significant strength increases and possible chemical cost savings are
to be gained by changing from a neutral sulphite to an alkaline sulphite process. Further work to
determine the reproducibility of these results, as well as the effect of different chemical charge and
ratios is suggested. / Thesis (M.Sc.Eng.)-University of Natal, Durban, 2000.
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Endodontic Radiolucency on a Mature Permanent Tooth in the Pediatric Population: Can the Tooth be Vital?Lentini, Erika 25 April 2014 (has links)
The objective was to determine the prevalence of vital teeth requiring non-surgical root canal therapy (NSRCT) that present with radiolucencies in mature permanent teeth in a pediatric population. A retrospective electronic dental chart review of children treated with NSRCT at VCU’s School of Dentistry between November 30, 2009 and March 1, 2013 was conducted. The presence or absence of a periapical radiolucency was determined from digital radiographs by three calibrated dentists. Specific characteristics of each tooth were collected. Statistical analysis using logistic regression was completed on all teeth with radiolucencies and vital teeth with radiolucencies. NSRCT was completed on 551 teeth. Radiolucencies were present in 246 teeth. Vitality data on access was only available in 184 teeth. In these, the prevalence of vital teeth with radiolucencies was 45.1% (n=83). Significant differences were noted for tooth type, gender, and puberty. Post-pubertal subjects had more vital teeth with radiolucencies than pubertal subjects.
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Lowering the Number of False Positive Responses to Electric Pulp Tests by Qualifying Patient ResponseLee, Katherine JS 01 January 2015 (has links)
The electric pulp test (EPT) has been shown to be a valuable tool in assessing pulp vitality. One of its drawbacks, however, is its high number of false positives. The purpose of this study was to determine if qualifying the type of sensation elicited by the test could lower the percentage of false positive responses. A retrospective chart review of an eleven-month period was conducted, examining all patients with necrotic teeth tested with the EPT. Of 189 teeth, when the patient responded to EPT at first sensation 23.3% of teeth were incorrectly identified as vital. When the patient was asked to respond only if they felt an uncomfortable sensation, the false positive rate was lowered to 8.5%, a statistically significant difference. No association was found between the teeth reclassified as necrotic and age, gender, type of tooth, or number of canals.
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A Justification for the Trend Towards Indirect Pulp TherapyKuhnen, Marissa 01 January 2015 (has links)
Purpose: The purpose of this retrospective chart review was to determine how primary molars needing vital pulp therapy have been treated in the past four years at Virginia Commonwealth University (VCU) and to determine which treatments: indirect pulp therapy (IPT), formocresol pulpotomy, and ferric sulfate pulpotomy have been successful. Methods: AxiUm records that contained the procedure codes D3120 (Pulp Cap – Indirect) or D3220 (Therapeutic Pulpotomy) were totaled by year. Visit records were queried again to identify treatment failures i.e. extractions or pulpectomy. Results: In 2010, 52% of vital pulp therapies were ferric sulfate pulpotomies and in 2014 over 90% were indirect pulp therapy. Indirect pulp therapy had a 96.2% success rate, formocresol pulpotomy had a 65.8% success rate and ferric sulfate had a 62.9% success rate at three years (PConclusions:Indirect pulp therapy is a successful treatment option for the primary tooth with deep caries approaching the pulp
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Impact of ingredient selection on rheological properties of a semi-liquid syrup model for use in pulp/paste candyStangl, Kimberly January 1900 (has links)
Master of Science / Food Science / Sajid Alavi / Pulp/paste candy is popular in Mexico and is gaining popularity around the world. Pulp/paste candy is characterized as a soft, semi-fluid candy with particles in a colloidal suspension, typically squeezed out of the package for consumption. It is made by hydrating gums in water and mixing them with corn syrup, acid, powdered/pulverized sugar, and other minor ingredients yielding a product around 80°Brix and pH between 2-3. Over time the sucrose in the candy tends to invert, causing two types of failure: package leakage and solidification in package. Based on the findings of previous work from Molina-Rubio et al. (2010), a modified semi-liquid syrup model system was created with corn syrup, sugar, gums, and water. The model system was used to identify the influence these ingredients had on viscosity and texture since these factors are linked to the typical modes of failure in pulp/paste candy. An oscillatory sweep was used on a controlled force rheometer to identify the linear viscoelastic range. Oneway ANOVA with Tukey HSD was used to compare % total solids levels with complex viscosity at 0.1 rad/sec (there was a significant difference between all levels) and minimum tan (delta) (mid and high level were similar). Using a stepwise method, ANOVA models were generated that showed statistically significant effects on complex viscosity for gum level and sugar level as well as interactions (p < 0.05) between invert syrup-water, gum-water, and sugar type-water. The type of gum and the amount of corn syrup used didn’t significantly impact on the viscosity of the system. Using probe tests helped to analyze samples that were too thick for the rheometer. Analysis showed an inflection point for exponentially increased hardness (85-93%TS) that should be further investigated. The stepwise regression model generated for stickiness showed that the invert syrup-water interaction was significant along with gum type. These results are applicable to the confectionery industry and can help companies test and create a candy that meets the packaging and shelf life constraints that they desire. Targeting invert syrup-water levels and the hydration of the gum will have the most impact on the final product’s viscosity and stickiness, which are important for primary package filling and storage. To create an easy to eat candy, no invert syrup should be used in formulation and gellan gum would be better to use than xanthan. Higher solids (> 85%) should also be avoided since it would create a candy that is harder to squeeze out of the package due to higher viscosity and textural hardness.
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Purification, application and immunolocalization of thermostable xylanasesGovender, Stephanie January 2014 (has links)
Submitted in fulfillment of the requirements of the degree of Master of Technology (Biotechnology), Durban University of Technology, Durban, South Africa, 2014. / Microbial enzymes are gaining worldwide attention due to their potential industrial applications. Microorganisms producing thermostable -xylanase and their associated hemicellulases have significant application in the paper and pulp, food, animal feed, and textile industries. The potential of partially purified xylanase from Thermomyces lanuginosus MC 134, Luminase PB 100, Luminase PB 200 (a commercial xylanase) and
T. lanuginosus DSM 5826 (Sigma Aldrich) was evaluated in bleaching of bagasse pulp. The temperature and pH optima for all the enzymes were 60°C and pH 6, respectively. The temperature (50- 80°C) and pH (5-8) stability of the enzymes were also assessed. All the enzymes were relatively stable at 60°C and pH 6 for 180 min. T. lanuginosus MC 134 retained 80% of its activity at 60°C and pH 6 for 180 min and PB 200 retained 75% of its activity at 80°C for 180 min. T. lanuginosus MC 134 also exhibited good alkaline stability at pH 8.
The commercial xylanases Luminase PB 100, Luminase PB 200, T. lanuginosus DSM 5826 (Sigma Aldrich) were purified to homogeneity using a gel filtration column packed with sephadex G-100 and characterized for Km and Vmax. However extracellular crude xylanases from T. lanuginosus MC 134 was purified to homogeneity using (N )2S04 precipitation and gel filtration column, packed with sephadex G-100. The purified
xylanases exhibited a molecular mass of- 26 to 24 kDa, given range as determined by SDS page. The Km and Vmax values of Luminase PB 100, Luminase PB 200,
T. lanuginosus MC 134, and T. lanuginosus DSM 5826, xylanases were determined by the Michaelis-Menten equation using birchwood xylan as the substrate. The Km value for Luminase PB 100, Luminase PB 200, T. lanuginosus DSM 5826 and T. lanuginosus MC 134 were, 8.1 mg/mL, 11.7 mg/mL and 14.3 mg/mL respectively. The Vmax for Luminase PB 100, Luminase PB 200, T lanuginosus DSM 5826 and T lanuginosus MC 134 were 232.6, 454.6 and 74.6 !Jl11ol/min/mg.
Biobleaching conditions of the xylanases were also optimised and the release of reducing sugars and lignin derived compounds showed that an enzyme dosage of 50U/g of pulp was ideal for biobleaching at pH 6 and 60°C for 180 min. This brightness for T lanuginosus MC 134, Luminase PB 200, Luminase PB 100 was 45.5 ± 0.11%, 44.1 ± 0.007% and 42.7 ± 0.03% respectively at pH 6, compared to untreated samples. Reducing sugars and UV-absorbing lignin-derived compound values were considerably higher in xylanase-treated samples. All the enzymes analysed exhibited similar trends in the release of lignin derived compounds and reducing sugars which indicated their potential in the pulp and paper industry. / PDF Full-text unavailable. Please refer to hard copy for Full-text / M
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