In this paper, we discuss the question whether or not the real estate market is efficient. We define market efficiency and the efficient market hypothesis as it had been developed in the literature on financial markets. Then, we discuss the empirical evidence that exists concerning the efficiency or inefficiency of financial markets, usually seen as the reference markets as far as market efficiency is concerned. In a separate section, we turn to the real estate market. There, we define the real estate market and discuss various aspects that are decisive for the efficiency of that market. As it turns out, the result found in the literature is inconclusive. Majority of studies provide evidence supporting inefficiency of the real estate market while several studies maintain the notion of real estate market efficiency. / Series: SRE - Discussion Papers

Proefschrift Universiteit Maastricht. / Met bibliogr., lit. opg. - Met samenvatting in het Nederlands.

Les médicaments qui provoquent un allongement de la repolarisation cardiaque, mesuré sur l’électrocardiogramme (ECG) par la prolongation de l’intervalle QT, ont été associés à une augmentation du risque pro-arythmique, et plus particulièrement à la survenue de Torsades de pointes, une tachycardie ventriculaire polymorphe potentiellement mortelle. Les méthodes d'analyse du QT conventionnelles se restreignent à l’extraction de quelques complexes ECG. Cette pratique se traduit par de nombreuses limitations. L’inclusion de tous les battements enregistrés sur 24h et mesurés par des méthodes automatiques de mesure ECG a le potentiel de résoudre ces inconvénients. Ce travail de thèse a démontré que les méthodes de mesure ECG automatisées et les analyses continues peuvent supplanter les méthodes conventionnelles pour l'analyse de la prolongation du QT lors des essais cliniques. Des recommandations ont été établis afin de permettre une utilisation optimale des méthodes d'analyse ECG continues. / Drugs which induce a delay in cardiac repolarization measured as QT interval prolongation on the electrocardiogram (ECG) have been associated with a potential to increase the risk of arrhythmias, especially Torsades de pointes (TdP), a potentially lethal polymorphic ventricular tachycardia. The analyses performed using conventional methods are restricted to the extraction of a few ECG complexes. This practice is associated with several limitations. In contrast, the inclusion of all beats measured by computerized methods from continuous 24 h recordings could resolve all of these deficiencies. The current work demonstrated that automated ECG measurement methods employing continuous analysis can supplant conventional methods for the evaluation of QT prolongation in clinical studies. Recommendations have been established to provide an optimal use of continuous ECG analysis.

In the modern clinical and healthcare setting, the electronic collection and analysis of patient related vital signs and parameters are a fundamental part of the relevant treatment plan and positive patient response. Modern analytical techniques combined with readily available computer software today allow for the near real time analysis of digitally acquired measurements. In the clinical context, this can directly relate to patient survival rates and treatment success. The processing of clinical parameters, especially the Electrocardiogram (ECG) in the critical care setting has changed little in recent years and the analytical processes have mostly been managed by highly trained and experienced cardiac specialists. Warning, detection and measurement techniques are focused on the post processing of events relying heavily on averaging and analogue filtering to accurately capture waveform morphologies and deviations. This Ph. D. research investigates an alternative and the possibility to analyse, in the digital domain, bio signals with a focus on the ECG to determine if the feasibility of bit by bit or near real time analysis is indeed possible but more so if the data captured has any significance in the analysis and presentation of the wave patterns in a patient monitoring environment. The research and experiments have shown the potential for the development of logical models that address both the detection and short term predication of possible follow-on events with a focus on Myocardial Ischemic (MI) and Infraction based deviations. The research has shown that real time waveform processing compared to traditional graph based analysis, is both accurate and has the potential to be of benefit to the clinician by detecting deviations and morphologies in a real time domain. This is a significant step forward and has the potential to embed years of clinical experience into the measurement processes of clinical devices, in real terms. Also, providing expert analytical and identification input electronically at the patient bedside. The global human population is testing the healthcare systems and care capabilities with the shortage of clinical and healthcare providers in ever decreasing coverage of treatment that can be provided. The research is a moderate step in further realizing this and aiding the caregiver by providing true and relevant information and data, which assists in the clinical decision process and ultimately improving the required standard of patient care.

Imbalancen im Bereich der autonomen Innervation des Herzens auf Sinusknotenebene zeigen sich anhand des Fehlens der „heart rate variability“ und der „heart rate turbulence“ und werden bereits zur Risikoeinschätzung von KHK-Patienten herangezogen, während Untersuchungen zur autonomen Dysbalance auf Ventrikelebene bisher kaum durchgeführt wurden. Daher war das Ziel dieser Arbeit eine Risikostratifizierung von Patienten nach einem Myokardinfarkt anhand dynamischer Veränderungen der QT-Zeit, zu denen es nach einer ventrikulären Extrasystole kommt. In der Einleitung wird die Wichtigkeit der Beachtung allgemeiner kardiovaskulärer Risikofaktoren erläutert. Es wird auf die Komplexität der QT-Zeit, deren beeinflussende Faktoren sowie auf den Einfluss des autonomen Nervensystems auf die Repolarisation der Herzkammern eingegangen. Im Abschnitt „Material und Methode“ und in „Auswertungen und Berechnungen“ wird das Patientenkollektiv vorgestellt, außerdem werden die Programme beschrieben, die zum Erzeugen der Daten verwendet wurden. Als Ergebnis lässt sich festhalten, dass Schlag-zu-Schlag-Analysen der QT-Zeit nach ventrikulären Extrasystolen signifikante Unterschiede aufzeigen zwischen den Patienten, die einen Follow-up von zwei Jahren nach einem Myokardinfarkt überlebt haben und denen, die während dieses Beobachtungszeitraumes aufgrund kardiovaskulärer Komplikationen verstarben. Der Aufwand, der hierfür betrieben werden muss, ist jedoch so hoch, dass diese Analysen wohl nicht zur routinemäßigen Anwendung kommen werden. / Imbalance of the autonomic innervation of heart to sinus node level is shown by the lack of “heart rate variability” and “heart rate turbulence”, which are already used for risk stratification of patients with coronary artery disease, while there were hardly any investigations carried out on the autonomic imbalance at the level of the ventricle. Therefore the aim of this study was a risk stratification of patients, who had suffered myocardial infarction, based on dynamic changes of the QT interval, which occur after a ventricular premature beat. In the introduction, the importance of the observance of general cardiovascular risk factors is explained. It addresses the complexity of the QT interval, the influencing factors and the influence of the autonomic nervous system on the repolarization of the ventricles. In the section "Materials and Methods" and in "Evaluations and Calculations" the population of patients is presented, as well as the programs are described that were used to generate the data. The result can be seen therefore, that beat-to-beat measurements of the QT interval after ventricular premature beats show significant differences between those patients, who survived a follow-up of two years after myocardial infarction and those, who died during this period due to cardiovascular complications. The effort, which must be used for this purpose is so high, that these analyses will probably not be applicable as a matter of routine.

The CPR3 is a handheld radar device. This device is capable of detecting movement through walls and is mainly intended for police and military use. It is equipped with a Bluetooth module that enables remote control. To enhance the mobility of the users that utilize this functionality, a Windows Mobile application is developed. This application is meant to replace the already existing Windows application used for remotely controlling these radar devices. Furthermore, a small evaluation of the framework used for the development of the application is performed. Also, a theoretical performance analysis is performed on the ZigBee standard. The goal is to find out whether or not ZigBee is a suitable replacement technology for Bluetooth as the primary means of communication within the system.

To keep up in the rapidly changing market for smart mobile phones, newways of consuming information is needed. In this master thesis project aPortable Document Format (PDF) viewer with more features than existingPDF viewers for Symbian^3 was developed, called PDF Eagle. PDF Eaglewas implemented using the Qt framework, allowing it to be easily ported todierent platforms. PDF documents have a rich structure and to be fullycompatible with the standard and at the same time responsive enough to berun on a mobile platform is a formidable technical challenge. This reportdescribes the issues that had to be resolved all the way to a functioning "app"that was marketed on the Nokia market in October 2011 with a great success.Among the technical challenges was a way to correctly render coloured objectsin PDFs. A gradient is a way to colour an area in a PDF le. Results of testsshowed that PDF Eagle is more capable of handling gradients, shadows andencrypted PDF les compared to other mobile PDF viewers. The conclusion ofthis report is that PDF Eagle is on par with or outmatches other PDF viewerson the targeted platform. This work also shows the feasibility of incrementallydownloading the pages of a PDF le which provides a better user experienceby faster viewing.

<p>Sudden death from arrhythmia is a major cause of mortality in the United States. Unfortunately, no current diagnostic test can accurately predict risk for sudden arrhythmic death. Because ventricular arrhythmias often result from abnormalities of repolarization, assessment of myocardial repolarization using the electrocardiogram (ECG) can aid in prediction of arrhythmia risk. Non-linear, rate-dependent changes in myocardial repolarization can promote the development of arrhythmia, but few studies examine how these dynamic changes in repolarization affect the ECG. This dissertation describes the use of a computer model to investigate the effect of dynamic changes in myocardial repolarization on the ECG T wave.</p><p>To simulate action potential conduction from the endocardium to the epicardium of the free wall of the canine left ventricle, 1-dimensional multicellular computer fiber models were created. Each fiber model was composed of endocardial, midmyocardial, and epicardial cells. For each cell type, existing mathematical models were modified to approximate experimental data for four types of dynamic repolarization behavior: (1) dynamic restitution, the response to steady-state pacing; (2) S1-S2 restitution, the response to a premature or postmature stimulus; (3) short-term memory (STM), the response to an abrupt change in pacing rate; and (4) repolarization alternans, beat-to-beat alternation in cellular repolarization time. Repolarization times were obtained from endocardial, midmyocardial, and epicardial regions in the fiber model and compared to parameters measured from a computed transmural ECG.</p><p>Spatial differences in repolarization created two voltage gradients that influenced the ECG: an endocardial-midmyocardial (endo-mid) gradient and a midmyocardial-epicardial (mid-epi) gradient. Epicardial dynamic restitution changes altered the mid-epi gradient, influencing the rising phase of the ECG T wave, and endocardial dynamic restitution changes altered the endo-mid gradient, influencing the falling phase of the T wave. Changes in epicardial or endocardial repolarization due to S1-S2 restitution or STM caused transient changes in the rising or falling phase of the T wave, respectively.</p><p>During repolarization alternans, an alternating, asymmetric distribution of extracellular potential around the fiber influenced the measurement of T-wave alternans (TWA) in the ECG. Presence of a resistive barrier in the fiber model altered the magnitude of repolarization alternans as well as the TWA amplitude in the ECG with effects dependent on barrier location. The resistive barrier also modified the relationship between cellular repolarization alternans magnitude and TWA amplitude.</p><p>The results presented in this dissertation explain basic mechanisms by which dynamic changes in myocardial repolarization affect the ECG T wave. These mechanisms form the foundation for the development of techniques to identify arrhythmogenic, dynamic changes in the myocardium using the ECG. Future studies in higher-dimensional, more complex models will build upon these results by considering the influence of additional voltage gradients, more realistic tissue geometries, and heterogeneities in the volume conductor.</p> / Dissertation

Gemeinsamer Workshop von Universitaetsrechenzentrum und Professur Rechnernetze und verteilte Systeme (Fakultaet fuer Informatik) der TU Chemnitz. Workshop-Thema: Infrastruktur der ¨Digitalen Universitaet¨ Der Vortrag stellt einen kleinen Ausschnitt aus dem Qt-Programmierkonzept vor: den Signal-Slot-Mechanismus. Als Beispielanwendung wird auf einen Noteneditor verwiesen.

Konstanz, FH, Diplomarb., 2003.