Microwave imaging finds numerous applications involving optically obscured targets. One particular area is breast cancer detection, since microwave technology promises fast low-cost image reconstruction without the use of harmful radiation typical of X-ray mammography. However, the success of microwave imaging is hindered by a critical issue, the complex nature of near-field electromagnetic scattering in tissue. To overcome this, specialized image reconstruction algorithms alongside sensitive measurement hardware are required. In this work, real-time near-field microwave imaging algorithms known as quantitative microwave holography and scattered power mapping are explored. They are experimentally demonstrated to identify potential tumor regions in tissue phantoms. Alongside this development, quality control techniques for evaluating microwave hardware are also described. Two new methods for improving the image reconstruction quality are also presented. First, a novel technique, which combines two commonly used mathematical approximations of scattering (the Born and Rytov approximations), is demonstrated yielding improved image reconstructions due to the complimentary nature of the approximations. Second, a range migration algorithm is introduced which enables near-field refocusing of a point-spread function (PSF), which is critical for algorithms that rely on measured PSFs to perform image reconstruction. / Thesis / Doctor of Philosophy (PhD) / Breast cancer remains as one of the highest causes of cancer-related deaths in women in Canada. Though X-ray mammography remains the gold standard for regular breast cancer screening, its use of harmful radiation, painful breast compression, and radiologist dependent evaluation remain as detracting factors for its use. Over the past 40 years, researchers have been exploring the use of microwave technology in place of X-ray mammography. Microwave radiation, used at power levels similar to that of a cellphone, has been demonstrated successfully in simulations of breast scans. However, in experimental evaluations with breast phantoms, the complex scattering path of the radiation through tissue complicates image reconstruction. In this thesis, methods of improving the accuracy of microwave algorithms are explored, alongside new breast phantom structures that replicate well the electrical properties of tissue. The results of this work demonstrate the flexibility of microwave imaging, and the adversities that still need to be overcome for it to begin seeing clinical use.