Made available in DSpace on 2014-10-09T12:51:02Z (GMT). No. of bitstreams: 0 / Made available in DSpace on 2014-10-09T14:08:05Z (GMT). No. of bitstreams: 1 11132.pdf: 10371292 bytes, checksum: 1b7d4e1304d84398e9d2d5f40d72ea2b (MD5) / Tese (Doutoramento) / IPEN/T / Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP

Made available in DSpace on 2014-10-09T12:26:21Z (GMT). No. of bitstreams: 0 / Made available in DSpace on 2014-10-09T14:09:59Z (GMT). No. of bitstreams: 0 / O uso de radioisótopos em medicina nuclear, seja para terapia ou diagnóstico, gera rejeitos radioativos. A quantidade e características desses rejeitos variam em função da quantidade de pacientes atendidos, do tipo de procedimento realizado e do radioisótopo utilizado. A gestão desses rejeitos abrange todas as atividades técnicas e administrativas envolvidas no manuseio dos rejeitos, desde a sua geração até seu destino final e deve ser considerada e planejada desde o momento da implementação do serviço de medicina nuclear. O objetivo principal da gestão de rejeitos radioativos é garantir a proteção do homem e a preservação do meio ambiente. O regulamento que estabelece as bases para a boa gestão dos rejeitos radioativos foi elaborado pela Comissão Nacional de Energia Nuclear, em 1985. Trata-se da Norma CNEN-NE-6.05 Gerência de rejeitos radioativos em instalações radiativas que embora seja um marco relacionado à gestão dos rejeitos radioativos e ajude em grande parte no papel de orientar no projeto de um sistema de gestão em instalações radioativas de usuários de radioisótopos, aborda os tópicos de forma generalizada e não considera aspectos particulares das diferentes instalações, como é o caso dos serviços de medicina nuclear. O presente trabalho pretende colaborar com referências que forneçam orientações sobre como cumprir as exigências regulatórias e descrever o sistema de gerência de rejeitos radioativos em serviços de medicina nuclear. / Dissertacao (Mestrado) / IPEN/D / Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP

Orientadores: José Antenor Pomilio, Giancarlo Tosin / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Elétrica e de Computação / Made available in DSpace on 2018-08-27T01:27:04Z (GMT). No. of bitstreams: 1 Baader_JohannEduardo_M.pdf: 5709999 bytes, checksum: b70a7b9c4f9062486fb33d399ad88653 (MD5) Previous issue date: 2015 / Resumo: Desde 1997 o Brasil tem acesso à tecnologia de radiação síncrotron com a inauguração do Laboratório Nacional de Luz Síncrotron (LNLS), localizado na cidade de Campinas, SP. Batizada de UVX, a fonte de luz síncrotron brasileira foi um marco no desenvolvimento científico e tecnológico do país, permitindo pesquisas nas mais diversas áreas do conhecimento, como nanotecnologia, biotecnologia, fármacos, agricultura, energias alternativas, dentre outros. Em 2009 o LNLS iniciou o projeto e a construção de uma nova fonte de luz síncrotron brasileira. Nomeada Sirius, está sendo desenvolvida para ser uma das mais avançadas do mundo na geração de luz síncroton. O alto desempenho deste tipo de máquina depende fortemente da qualidade dos campos magnéticos criados pelos inúmeros magnetos que compõem a rede magnética, o que exigem uma técnica de caracterização rápida, acurada e precisa. O Grupo de Magnetos, responsável pelo projeto, construção e caracterização dos magnetos tanto da fonte UVX como da nova fonte, utiliza um sistema de medição conhecido como Técnica de Bobina Girante. Devido às especificações do projeto Sirius, foi necessário o aprimoramento da bancada de caracterização, objetivo este consolidado principalmente através da análise minuciosa das principais fontes de erro do sistema. Um modelo numérico desenvolvido para estudar algumas classes de erros da técnica deu suporte para diversas correções na bancada, o que permitiu alcançar níveis de precisão comparáveis com os sistemas de caracterização de outros laboratórios. Paralelamente, foi construída a bancada de um sistema protótipo de medição magnético, nomeado Técnica de Minibobina Girante, apresentando uma série de vantagens em relação às limitações da bancada oficial. Algumas das melhorias realizadas nesta bancada durante o seu desenvolvimento foram baseadas nos resultados advindos do modelo numérico das fontes de erros / Abstract: Since 1997 Brazil has access to synchrotron radiation technology with the inauguration of the Brazilian Synchrotron Light Source (LNLS), located in Campinas, Brazil. The source of Brazilian synchrotron light known as UVX was a milestone in scientific and technological development of the country, enabling research in several areas of knowledge such as nanotechnology, biotechnology, pharmaceuticals, agriculture, alternative energy etc. In 2009 LNLS initiated the project and the construction of a new source of Brazilian synchrotron light, named Sirius. It is being developed to be one of the most advanced in the world in the generation of synchrotron light. The high performance of this type of machine depends strongly on the quality of the magnetic fields created by magnets that compose the lattice, which demand a fast, accurate and precise characterization technique. The Magnets Group, responsible for the design, construction and characterization of both the magnetic UVX sources as new sources, uses a measuring system known as Rotating Coil System. Due to the specifications of the Sirius design, an improved characterization bench was necessary. This goal was achieved mainly through a careful analysis of the main sources of error in the system. A numerical model to study some classes of errors in the technique provided support for various fixes in the bench, which allowed us to achieve comparable levels of accuracy along with the characteristics of the systems from other laboratories. At the same time, another bench was built as a prototype system for magnetic measurements known as Small Rotating Coil System, presenting a series of advantages over the constraints of the main bench. Some of the improvements made on this bench during its development were based on the results derived from the numerical model of error sources / Mestrado / Energia Eletrica / Mestre em Engenharia Elétrica

More than hundred years after the discovery of X-rays different kinds of ionizing radiation are ubiquitous in medicine, applied to clinical diagnostics and cancer treatment as well. Irrespective of their nature, the widespread application of radiation implies its precise dosimetric characterization and detailed knowledge of the radiobiological effects induced in cancerous and normal tissue. Starting with in vitro cell irradiation experiments, which define basic parameters for the subsequent tissue and animal studies, the whole multi-stage process is completed by clinical trials that translate the results of fundamental research into clinical application. In this context, the present dissertation focuses on the establishment of radiobiological in vitro cell experiments at unconventional, but clinical relevant radiation qualities. In the first part of the present work the energy dependent biological effectiveness of photons was studied examining low-energy X-rays (≤ 50 keV), as used for mammography, and high-energy photons (≥ 20 MeV) as proposed for future radiotherapy. Cell irradiation experiments have been performed at conventional X-ray tubes providing low-energy photons and 200 kV reference radiation as well. In parallel, unconventional quasi-monochromatic channeling X-rays and high-energy bremsstrahlung available at the radiation source ELBE of the Forschungszentrum Dresden-Rossendorf were considered for radiobiological experimentation. For their precise dosimetric characterization dosimeters based on the thermally stimulated emission of exoelectrons and on radiochromic films were evaluated, whereas just the latter was found to be suitable for the determination of absolute doses and spatial dose distributions at cell position. Standard ionization chambers were deployed for the online control of cell irradiation experiments. Radiobiological effects were analyzed in human mammary epithelial cells on different subcellular levels revealing an increasing amount of damage for decreasing photon energy. For this reason, the assumed photon energy dependence was reconfirmed for a cell line other than human lymphocytes, an important finding that was discussed on the 2007 Retreat of the German Commission on Radiological Protection. After successful finalization of the photon experiments the focus of the present dissertation was directed to the realization of in vitro cell irradiation experiments with laser-accelerated electrons. This research was carried out in the frame of the project onCOOPtics that aims on the development of laser-based particle accelerators, which promise accelerators of potentially compact size and more cost-effectiveness suitable for a widespread medical application, especially for high precision hadron therapy. The unique properties, i.e., the ultrashort bunch length and resultant ultrahigh pulse dose rate, of these unconventional particle accelerators demand for extensive investigations with respect to potential effects on the dosimetric and radiobiological characterization. Based on the experiences gained at ELBE first experiments on the radiobiological characterization of laser-accelerated electrons have been performed at the Jena Titanium:Sapphire laser system. After beam optimization, a sophisticated dosimetry system was established that allow for the online control of the beam parameters and for the controlled delivery of dose to the cell sample. Finally, worldwide first systematic in vitro cell irradiation experiments were carried out resulting in a reduced biological effectiveness for laser-accelerated electrons relative to the 200 kV X-ray reference, irrespectively on the biological effect and cell lines examined. These successful results are the basis for future in vivo studies and experiments with laser-accelerated protons.

The X-ray optics of synchrotron radiation beamlines are considered in this paper. The characteristics of synchrotron radiation which make it the premier source of light for studies in many regions of the electromagnetic spectrum are given. A chapter is devoted to the collimating, focusing and monochromating optics of two X-ray diffraction beamlines at the National Synchrotron Light Source. The beamlines are operated by the Naval Research Laboratory (NRL) and the Oak Ridge National Lab (ORNL). The major optical components of these beamlines are reviewed in regards to their function and their flexibility. A detailed analysis is performed on the NRL X-ray collimating mirror. The mirror is treated as an elastically bent beam. Deflection and slope error equations are developed which relate the shape of the bent mirror to its ideal surface. Visible light diffraction patterns collected from the mirror helped to establish operating conditions which provide good collimation. When the observed patterns are wed to the theoretical calculations, estimates of the average figure error are made. Finally, the effect of a highly collimated synchrotron beam on the reproducibility of the integrated intensities from polycrystalline materials is considered. The calculations show that except for the most fine grained materials, representative intensity measurements can only be made when the sample is permitted to move. / M.S.

Fluorescent x-ray screens are used in medical x-ray diagnostics to absorb x-ray photons and convert these x-ray photons to visible light. The light distribution from these screens are then registered on photographic film to give an x-ray image. Both the sensitivity and the resolution characteristics of these systems are dependent on the x-ray photon energy. To enable a study of these and some other energy dependent characteristics of x-ray screens a number of almost monoener-getic radiation sources were constructed, tested with regard to their purity and calibrated. Both film and a photo-multiplier tube were used as light detectors.The sensitivity of screens with three different screen phosphors were studied as a function of the photon energy and large variations in sensitivity was found for different photon energies and screen phosphors. The light from the screens has been compared to the absorbed energy in the screens and this comparison shows that the energy dependence of the screens can approximately be predicted by calculations of the absorbed energy, except at low photon energies where other effects like increased light absorption in the screens is present.The modulation transfer factor (MTF) was studied both experimentally and theoretically as a function of photon energy. Two effects were shown to influence the energy dependence of the MTF. At low energies an increased light diffusion will destroy the MTF and at energies above the K-edge of the high-Z elements in the screens the production and re-absorption of K-radiation will deteriorate the MTF.Both the energy dependence of the screen-film sensitivity and the MTF have been calculated for some normally used spectral distributions from x-ray tubes and significant changes due to choice of kV and filtration of the beam were found. Other effects such as the number of interacting photons in the screens per unit area, contribution of K-radiation from one screen to the other, and light contribution to the front emulsion of the film compared to the back emulsion have also been investigated as a function of photon energy.Optimization of x-ray systems and clinical routines to give the lowest possible radiation dose to the patient with an acceptable image quality is an important task to carry out. The energy dependent characteristi es of x-ray screens studied in this work is a lead in the optimizing of the system with regard to choice of x-ray screens, film and radiation quality. / digitalisering@umu

Made available in DSpace on 2014-10-09T12:28:08Z (GMT). No. of bitstreams: 0 / Made available in DSpace on 2014-10-09T14:01:44Z (GMT). No. of bitstreams: 0 / Dissertacao (Mestrado) / IPEN/D / Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP

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Made available in DSpace on 2014-10-09T12:41:36Z (GMT). No. of bitstreams: 0 / Made available in DSpace on 2014-10-09T14:08:54Z (GMT). No. of bitstreams: 0 / Dissertação (Mestrado) / IPEN/D / Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP