Lam Wai-man Wynnie. / "April 2002." / Thesis (M.D.)--Chinese University of Hong Kong, 2002. / Includes bibliographical references (p. 109-134). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Mode of access: World Wide Web.

Submitted by Bianca de Fátima Pinheiro null (bih_pinheiro@hotmail.com) on 2017-03-25T00:39:00Z No. of bitstreams: 1 Defesa - Bianca Pinheiro - VERSÃO FINAL (1).pdf: 3735855 bytes, checksum: f6debe5602c92a8fb95b71a7c3ba52c9 (MD5) / Approved for entry into archive by Luiz Galeffi (luizgaleffi@gmail.com) on 2017-03-29T18:26:16Z (GMT) No. of bitstreams: 1 pinheiro_bf_me_bot.pdf: 3735855 bytes, checksum: f6debe5602c92a8fb95b71a7c3ba52c9 (MD5) / Made available in DSpace on 2017-03-29T18:26:16Z (GMT). No. of bitstreams: 1 pinheiro_bf_me_bot.pdf: 3735855 bytes, checksum: f6debe5602c92a8fb95b71a7c3ba52c9 (MD5) Previous issue date: 2017-02-24 / Neste trabalho foram analisados os custos financeiros decorrentes da implantação de um serviço de radioterapia intraoperatória (IORT), considerando os valores gastos para a construção do centro cirúrgico e demais dependências necessárias anexas a um serviço de radioterapia pré-existente, bem como os valores de aquisição de acessórios específicos para IORT para uso em um acelerador linear clínico. Foi comparada a realização do procedimento de IORT com o acelerador linear fixo e com o equipamento irradiador móvel (INTRABEAM®). Os dados obtidos foram coletados por e-mail e telefone junto aos serviços de radioterapia cadastrados na Sociedade Brasileira de Radioterapia, e junto aos fornecedores do ramo de radioterapia (Medical Systems, Elekta Medical Systems e ZEISS), além disso, o ambiente destinado para IORT do Hospital das Clínicas de Botucatu foi avaliado nos aspectos sócios econômicos. Foram analisados artigos publicados por serviço de radioterapia que realizam IORT, e selecionados os 10 principais, ilustrando a eficiência do procedimento. A pesquisa com os centros de radioterapia apontou que dos participantes apenas 17,7% realizam o procedimento. Os custos apontados para a instalação do serviço de IORT no Hospital das Clínicas de Botucatu somam a quantia de R$290.000,00. Comparando o Acelerador Linear com o INTRABEAM®, ambos possuem um tempo total gasto no procedimento semelhante. A avaliação do CONITEC do Ministério da Saúde mostrou não ser favorável para a incorporação da IORT usando o INTRABEAM® no SUS. Avaliando os repasses financeiros para o procedimento de IORT, o SUS ainda não incorporou nas suas diretrizes, no entanto, de acordo com a esfera privada, o procedimento de IORT custaria em torno de R$11.000,00, levando em consideração os gastos do Hospital das Clínicas de Botucatu, são necessárias à realização de 27 procedimentos para a reposição do investimento inicial. São ilustrados os benefícios terapêuticos da técnica de IORT frente à radioterapia convencional. Também estão ilustrados os parâmetros físicos analisados no processo de controle de qualidade dos procedimentos de radioterapia intraoperatória. O trabalho aponta que a IORT pode contribuir para minimizar a concentração de pacientes em processo de espera pelo tratamento convencional fracionado, e assim proporcionar maior conforto aos doentes, além de reduzir os custos dos procedimentos radioterápicos atualmente reembolsados pelos sistemas de saúde. / In this study, the financial costs resulting from the implantation of an intraoperative radiotherapy service (IORT) were analyzed, considering the amounts spent for the construction of the surgical center and other necessary dependencies attached to a pre-existing radiotherapy service, as well as the acquisition values IORT-specific accessories for use in a clinical linear accelerator. The IORT procedure was compared with the fixed linear accelerator and with the mobile radiator device (INTRABEAM®). The data obtained were collected by e-mail and telephone with radiotherapy services registered at the Brazilian Society of Radiotherapy, and with radiotherapy providers (Medical Systems, Elekta Medical Systems and ZEISS), and the environment for IORT Of the Botucatu Clinic Hospital was evaluated in the socioeconomic aspects. We analyzed published articles by radiotherapy service that performed IORT, and selected the 10 main ones, illustrating the efficiency of the procedure. The research with the radiotherapy centers pointed out that of the participants only 17.5% performed the procedure. The costs indicated for the installation of the IORT service at Botucatu Clinic Hospital add up to the amount of R$ 290.000,00. Comparing the Linear Accelerator with INTRABEAM®, both have a total time spent in the similar procedure. The CONITEC evaluation of the Ministry of Health was not favorable for the incorporation of IORT using INTRABEAM® in the SUS. Evaluating the financial onlendings for the IORT procedure, the SUS has not yet incorporated into its guidelines, however, according to the private sphere, the IORT procedure would cost around R$ 11.000,00, taking into account the Botucatu Clinic Hospital, are necessary to carry out 27 procedures for the replacement of the initial investment. The therapeutic benefits of IORT versus conventional radiotherapy are illustrated. Also shown are the physical parameters analyzed in the quality control process of the intraoperative radiotherapy procedures. The study points out that IORT can contribute to minimizing the concentration of patients waiting for the conventional fractionated treatment, thus providing greater comfort to the patients, besides reducing the costs of the radiotherapy procedures currently reimbursed by the health systems.

Orientador: Marco Antônio Rodrigues Fernandes / Resumo: Neste trabalho foram analisados os custos financeiros decorrentes da implantação de um serviço de radioterapia intraoperatória (IORT), considerando os valores gastos para a construção do centro cirúrgico e demais dependências necessárias anexas a um serviço de radioterapia pré-existente, bem como os valores de aquisição de acessórios específicos para IORT para uso em um acelerador linear clínico. Foi comparada a realização do procedimento de IORT com o acelerador linear fixo e com o equipamento irradiador móvel (INTRABEAM®). Os dados obtidos foram coletados por e-mail e telefone junto aos serviços de radioterapia cadastrados na Sociedade Brasileira de Radioterapia, e junto aos fornecedores do ramo de radioterapia (Medical Systems, Elekta Medical Systems e ZEISS), além disso, o ambiente destinado para IORT do Hospital das Clínicas de Botucatu foi avaliado nos aspectos sócios econômicos. Foram analisados artigos publicados por serviço de radioterapia que realizam IORT, e selecionados os 10 principais, ilustrando a eficiência do procedimento. A pesquisa com os centros de radioterapia apontou que dos participantes apenas 17,7% realizam o procedimento. Os custos apontados para a instalação do serviço de IORT no Hospital das Clínicas de Botucatu somam a quantia de R$290.000,00. Comparando o Acelerador Linear com o INTRABEAM®, ambos possuem um tempo total gasto no procedimento semelhante. A avaliação do CONITEC do Ministério da Saúde mostrou não ser favorável para a incorporação da ... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: In this study, the financial costs resulting from the implantation of an intraoperative radiotherapy service (IORT) were analyzed, considering the amounts spent for the construction of the surgical center and other necessary dependencies attached to a pre-existing radiotherapy service, as well as the acquisition values IORT-specific accessories for use in a clinical linear accelerator. The IORT procedure was compared with the fixed linear accelerator and with the mobile radiator device (INTRABEAM®). The data obtained were collected by e-mail and telephone with radiotherapy services registered at the Brazilian Society of Radiotherapy, and with radiotherapy providers (Medical Systems, Elekta Medical Systems and ZEISS), and the environment for IORT Of the Botucatu Clinic Hospital was evaluated in the socioeconomic aspects. We analyzed published articles by radiotherapy service that performed IORT, and selected the 10 main ones, illustrating the efficiency of the procedure. The research with the radiotherapy centers pointed out that of the participants only 17.5% performed the procedure. The costs indicated for the installation of the IORT service at Botucatu Clinic Hospital add up to the amount of R$ 290.000,00. Comparing the Linear Accelerator with INTRABEAM®, both have a total time spent in the similar procedure. The CONITEC evaluation of the Ministry of Health was not favorable for the incorporation of IORT using INTRABEAM® in the SUS. Evaluating the financial onlendings for ... (Complete abstract click electronic access below) / Mestre

The lateral penumbra of a proton pencil beam scanning system (PBS) is of great importance in sparing of organs at risk and normal tissue when treating patients. The purpose of this current work is to measure the lateral penumbra of the Ion Beam Applications (Ion Beam Applications, Louvain‐la‐Neuve, Belgium) ProteusPLUS PBS Proton Therapy System and compare the measurements with the computed results from the RayStation proton treatment planning system. The lateral penumbra (80%-20%) was measured using EBT-3 Gafchromic film in the water tank. The lateral penumbra was studied for various parameters such as range, depth, and air gap. The computed lateral penumbra was found to be higher than the measured lateral penumbra by up to 2.3 mm in the case of depth dependency at 30 cm, and lower by up to 1.18 mm in the case of an air gap of 15 cm. / Includes bibliography. / Thesis (M.S.)--Florida Atlantic University, 2019. / FAU Electronic Theses and Dissertations Collection

Two-dimensional transmission dosimetry in radiotherapy has been discussed in the literature for some time as being a potential method for in vivo dosimetry. However, it still remains to become a wide spread practice in radiotherapy clinics. This is most likely due to the variety in radiotherapy treatment sites and the challenges they would present in terms of detection and interpretation at the transmitted dose level. Thus, the full potential and limitations of applying transmission dosimetry in the presence of dosimetry errors still need to be demonstrated. This thesis is a theoretical evaluation of transmission dosimetry using the Pinnacle3 treatment planning system. The accuracy of predicting reliable and accurate absolute transmitted dose maps using the planning system dose algorithm for comparison with measured transmitted dose maps was initially investigated. The resolution in the dose calculations at the transmitted level was then evaluated for rectilinear and curved homogeneous phantoms and rectilinear inhomogeneous phantoms, followed by studies combining both surface curvature and heterogeneities using anthropomorphic phantoms. In order to perform transmitted dose calculations at clinically relevant beam focus-to-transmitted dose plane distances using clinical patient CT data it was first necessary to extend the CT volume. Finally, the thesis explored the efficacy of applying transmission dosimetry in the clinic by simulating realistic dosimetry errors in the planning system using patient treatment plans for a prostate, head and neck, and breast CRT (Conformal Radiotherapy) treatment. Any differences at the transmitted dose level were interpreted and quantified using the gamma formalism. To determine whether the transmitted dose alone was a sufficient indicator of the dosimetry errors, the magnitude in transmission dose differences were compared with those predicted at the midplane of the patient. Dose-Volume Histograms (DVHs) were also used to evaluate the clinical significance of the dose delivery errors on the target volume and surrounding healthy tissue structures. / http://proxy.library.adelaide.edu.au/login?url= http://library.adelaide.edu.au/cgi-bin/Pwebrecon.cgi?BBID=1339807 / Thesis (Ph.D.) - University of Adelaide, School of Chemistry and Physics, 2008

Thesis (M.Sc.). / Written for the Medical Physics Unit. Title from title page of PDF (viewed 2008/05/29). Includes bibliographical references.

Thesis (M.Sc.). / Written for the Medical Physics Unit. Title from title page of PDF (viewed 2008/07/29). Includes bibliographical references.

Thesis (M.S.)--Medical University of Ohio, 2005. / "In partial fulfillment of the requirements for the degree of Master of Science in Biomedical Sciences." Major advisor: E. Ishmael Parsai. Includes abstract. Document formatted into pages: 144 p. Title from title page of PDF document. Title at ETD Web site: Development of Graphical User Interfaces (GUI) software and databases for radiation therapy applications. Bibliography: page 65.

Thesis (Masters Diploma (Technology))--Cape Technikon, Cape Town, 1995 / The development of a 200 MeV clinical proton therapy facility at the National Accelerator Centre required an interlock and control system to supervise the delivery of radiation to a patient. The interlock and control system is responsible for ensunng that nobody enters the treatment vault during an irradiation, the extraction of the beamstop devices 'from the beam-line to allow the irradiation of the patient and the insertion of those beam-stop devices when an error condition is detected. Because of its nature, the interlock and control system should be designed so that in the event of an error condition being detected, it should fail to a safe state. This is achieved by modelling the interlock and control system with an appropriate modeling method. This thesis describes a graphical modelling method called Petri-nets, which was used to model the system, and the software developed from the model.

Diffuse midline glioma (DMG) is the most aggressive primary brain tumor in children. All previous studies examining the role of systemic agents have failed to demonstrate a survival benefit; the only standard of care is radiation therapy (RT), which provides transient symptomatic relief and limited survival advantage. Successful implementation of radiosensitization strategies in DMG remains elusive. In this project, we identify Napabucasin, an NAD(P)H Quinone Dehydrogenase 1 (NQO1)-bioactivatable reactive oxygen species (ROS) inducer, as a potent radiosensitizer in DMG both in vitro and in vivo. We show Napabucasin-mediated ROS production and cytotoxicity are dependent on NQO1, and establish the novel safety, feasibility, and survival benefit of convection-enhanced drug delivery (CED) of Napabucasin to circumvent the blood-brain barrier (BBB) concurrent with RT in an orthotopic DMG mouse model. Using this multi-modality strategy, we identify a promising treatment paradigm in DMG that may also be utilized to develop novel therapeutic treatments for other brain tumors.