NDLTD Global ETD Search
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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

Search results

Showing 491 to 500 of 4284 (0.049 seconds)
491

Characterisation and comparative autoradiography of #alpha#←2-adrenoceptors and I←2-sites in mammalian brain

Hudson, Alan Leslie January 1994 (has links)
No description available.
615.1
492

An investigation of glial metabotropic glutamate receptors and their signalling mechanisms

Kanumilli, Srinivasan January 2001 (has links)
No description available.
615.1
493

ESTROGEN BINDING SITES IN HUMAN NEOPLASIA; DETECTION USING A MORPHOLOGIC TECHNIQUE.

PENNY, ROBERT JAMES. January 1984 (has links)
Thirty six cases of human endometrium (9 normals, 9 adenomatous hyperplasias and 18 cancers) were established as finite monolayer tissue cultures. All were evaluated for the presence of estrogen binding sites (EBS) by an indirect immunofluorescent (IF) technique. Positive EBS were identified in 33% of normals, 67% of hyperplasias and 62% of cancers. Serial subpassage EBS evaluation was performed in fourteen cases. In was observed that the stability of EBS positivity in vitro was related to type of endometrium rather than culture longevity (2 of 2 normals, 2 of 4 hyperplasias and 1 of 8 cancers remained positive throughout the period of study). Twelve of the cancers were studied for estrogen receptor by cytosol assay and 11 (91.6%) correlated with the IF marker method. Thirty-eight cases of breast cancer were studied for EBS by a direct cytochemical and immunofluorescent technique. Evaluation by the direct method proved to be consistent and easy in performance. Morphologic positivity was 60% with the indirect method and 94.7% with the direct method. Correlation with the chemical cytosol was 77% with the indirect method and 86.8% with the direct method. These results confirm and compare favorably with other reported studies of morphologic methods. It was suggested that attention should be directed to cellular localization of receptors as a possible means for predicting endocrine responsiveness of neoplasms. Cancers from tissues presumed to be target-variants for estrogen stimulation were investigated with the direct cytochemical technique to determine if EBS were present. Forty-eight randomly selected tumors from multiple organ systems were assessed for EBS. Appropriate control tests were used to determine specificity. A total of 23 of the 48 cases were interpreted as positive for EBS. These sites were localized to cytoplasmic, nuclear and nucleolar cellular compartments. Estrogen and progesterone receptors in patients with breast carcinoma are of value in the selection of patients for hormonal adjuvant therapy. Whether this will prove to be true for EBS in a variety of neoplasms is currently unknown and is worthy of investigation.
Binding sites (Biochemistry)
Estrogen -- Receptors.
Tumors -- Treatment.
494

ISOLATION AND IN VITRO CHARACTERIZATION OF MAMMALIAN CEREBRAL CORTICAL FACTORS INTERACTIVE WITH THE CENTRAL NERVOUS SYSTEM BENZODIAZEPINE RECEPTOR (ENDOGENOUS LIGANDS).

Chen, Andrew David. January 1985 (has links)
No description available.
Benzodiazepines -- Receptors.
Benzodiazepines.
Central nervous system.
Neurotransmitters.
495

The role of CD4 and CXCR4 mediated apoptosis in T cell depletion during HIV-1 infection

Ritsou, Elena January 2001 (has links)
No description available.
579
496

Studies on the processing of proenkephalin A by the prohormone converting enzymes PC1 and PC2

Brar, Bhawanjit Kaur January 1995 (has links)
No description available.
572
497

The role of αv integrins in regulating keratinocyte behaviour

Thomas, Gareth J. January 2000 (has links)
No description available.
572.8
498

Studies on the regulation of the Oct-4 gene in embryonal carinoma cells

Sylvester, Ian January 1995 (has links)
No description available.
572.8
499

Investigation of the agrin and neuregulin pathways in the neuromuscular junction disorganisation of the kyphoscoliotic mouse

Biggin, Andrew January 1998 (has links)
No description available.
572
500

A study of the application of ligand binding to the ultrasensitive measurement of receptors

Farajollahi, Mohammad Morad January 1997 (has links)
No description available.
610

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