Fluorescence enhanced optical tomography is a promising molecular imaging modality which employs a near infrared fluorescent molecule as an imaging agent and time-dependent measurements of fluorescent light propagation and generation. In this dissertation a novel fluorescence tomography algorithm is proposed to reconstruct images of targets contrasted by fluorescence within the tissues from boundary fluorescence emission measurements. An adaptive finite element based reconstruction algorithm for high resolution, fluorescence tomography was developed and validated with non-contact, planewave frequency-domain fluorescence measurements on a tissue phantom. The image reconstruction problem was posed as an optimization problem in which the fluorescence optical property map which minimized the difference between the experimentally observed boundary fluorescence and that predicted from the diffusion model was sought. A regularized Gauss-Newton algorithm was derived and dual adaptive meshes were employed for solution of coupled photon diffusion equations and for updating the fluorescence optical property map in the tissue phantom. The algorithm was developed in a continuous function space setting in a mesh independent manner. This allowed the meshes to adapt during the tomography process to yield high resolution images of fluorescent targets and to accurately simulate the light propagation in tissue phantoms from area-illumination. Frequency-domain fluorescence data collected at the illumination surface was used for reconstructing the fluorescence yield distribution in a 512 cm3, tissue phantom filled with 1% Liposyn solution. Fluorescent targets containing 1 micro-molar Indocyanine Green solution in 1% Liposyn and were suspended at the depths of up to 2cm from the illumination surface. Fluorescence measurements at the illumination surface were acquired by a gain-modulated image intensified CCD camera system outfitted with holographic band rejection and optical band pass filters. Excitation light at the phantom surface source was quantified by utilizing cross polarizers. Rayleigh resolution studies to determine the minimum detectable sepatation of two embedded fluorescent targets was attempted and in the absence of measurement noise, resolution down to the transport limit of 1mm was attained. The results of this work demonstrate the feasibility of high-resolution, molecular tomography in clinic with rapid non-contact area measurements.

This interdisciplinary research project combines the fields of nautical archaeology and computer visualization to create an interactive virtual reconstruction of the 1606 Portuguese vessel Nossa Senhora dos Mártires, also known as the Pepper Wreck. Using reconstruction information provided by Dr. Filipe Castro (Texas A&M Department of Anthropology), a detailed 3D computer model of the ship was constructed and filled with cargo to demonstrate how the ship might have been loaded on the return voyage from India. The models are realistically shaded, lighted, and placed into an appropriate virtual environment. The scene can be viewed using the real-time immersive and interactive system developed by Dr. Frederic Parke (Texas A&M Department of Visualization). The process developed to convert the available information and data into a reconstructed 3D model is documented. This documentation allows future projects to adapt this process for other archaeological visualizations, as well as informs archaeologists about the type of data most useful for computer visualizations of this kind.

A projected fringe profilometry (PFP) is an optical measurements technology which is widely used at present in gauging the object's three dimensional appearance. PFP is frequently used in detecting the quality of products in the industry due to the specialty of non-contact type, the short retrieve time and low environmental effect. As a result of the development for many years, PFP treats in the gauging static state of the object's three dimensional appearance has had the extremely fine gauging efficiency and the precision in , however in the dynamic inspected object in the gauging , not yet was still mature. If could to develop a set of gauging way in the dynamic inspected object , the application would be more widespread. Taking PFP as the gauging principle, analyzing the changes between the dynamic treat measured object and the fringe. Using the simple mathematics to describe the interaction relations between the fringe and the inspected the object. Finally, reconstructed the inspected object' three dimensional appearance. May know biggest superiority by the experimental process, in the situation of without losing the information of fringe, PFP can reconstruct the inspected object' three dimensional appearance and do not need the motion condition information.

In this thesis we treat two inverse problems concerning the determination of unknown boundary terms. <br />We deal with the stability issue and the reconstruction one as well.

Texte remanié de: Diss.--Kulturwissenschaftliche Fakultät--Universität Bayreuth, 1997. / Bibliogr. p. 345-358.

Thèse de doctorat--Signal et images--Paris--ENST, 2007. / Bibliogr. p. 159-175. Index. Résumé en anglais et en français.

Thèse de doctorat : Images et Systèmes : Villeurbanne, INSA : 2002. / Le chap.7 est rédigé en anglais. Titre provenant de l'écran-titre. Bibliogr. p.145-150.

Thesis (Ph. D.)--Oregon State University, 2010. / Printout. Includes bibliographical references (leaves 115-117). Also available on the World Wide Web.

Thesis (Ph. D.)--University of Washington, 2003. / Vita. Includes bibliographical references (leaves 113-124).

Includes bibliographical references (p. 114-123).