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No description available.

Numerical models (GMS MODFLOW, SEAM3D, and SEAM3D Interface) were applied to simulate groundwater flow, petroleum hydrocarbon compound (PHC) transport and biodegradation, and the transport and biotransformation of chlorinated ethenes at Site FT-002 Plattsburgh Air Force Base (PAFB), NY. Site FT-002 was contaminated with waste jet fuel and chlorinated ethenes used as a fire source during fire fighting training. The results of groundwater analysis indicated that the aquifer exhibited aerobic, nitrate reducing, ferrogenic, sulfate reducing and methanogenic conditions due to the biodegradation of the PHCs. Additional groundwater analysis showed the biotransformation of TCE to DCE, VC, and ethene. A numerical model was developed to simulate and assess the extent to which reductive dechlorination and direct anaerobic oxidation were responsible for the biotransformation of the chlorinated ethenes. Reductive dechlorination accounted for the 100%, 98.3%, and 97.5% of the biotransformation of TCE, DCE, and VC respectively. Direct anaerobic oxidation accounted for 1.7% and 2.5% of the biotransformation of DCE and VC respectively. Though direct anaerobic oxidation only accounted for a small percentage of total biotransformation it was necessary to fully develop the biotransformation of the DCE and VC in the ferrogenic zone. This study focused on the mechanisms responsible for the biotransformation of chlorinated ethenes, specifically reductive dechlorination and direct anaerobic oxidation. By further defining the NAPL source and initial conditions it could be used as a tool to accurately predict the monitored natural attenuation (MNA) of the FT-002 contaminant plume. / Master of Science

Groundwater contaminants such as chlorinated ethenes, chlorinated ethanes and nitroaromatic explosive compounds (e.g. 2,4,6-Trinitrotoluene (TNT)) degrade in the subsurface primarily by microbially catalyzed reductive transformation reactions. From a regulatory point of view, the capability to simulate the kinetics of these reductive transformation reactions coupled with other attenuation processes in the subsurface (e.g., sorption, advection, and dispersion) is required for site-specific solute transport models. A kinetic model based on Michaelis-Menten type equations (Widdowson 2004) has been successfully validated for the linear reductive dechlorination pathway of chlorinated ethenes, and implemented in solute transport codes such as SEAM3D (Waddill and Widdowson 2000). However, TNT degrades through more complex branched pathways, and kinetic models are lacking in the current literature. This research study was undertaken with the objective of extending the kinetic model developed for the linear reductive pathway of chlorinated ethenes to branched pathways. The proposed extended kinetic model was validated with experimental concentration-time data of TNT and its metabolites from two prior published laboratory studies (Daun et al. 2000; Hwang et al. 2000), both in the presence and absence of sorption. The model-predicted concentrations with time of TNT and its degradation intermediates and end-products correlated well with the experimental data. The model is further compatible with and can be easily incorporated into solute transport codes (e.g., SEAM3D), and used to evaluate the fate and transport of TNT and other similar contaminants in the subsurface. / Master of Science

The central aim of this thesis is to argue that the autonomous nature of mentalistic explanation presents a stronger constraint on what counts as a satisfactory statement of the relation between the mental and the physical than can be acknowledged within the metaphysical framework of non-reductive physicalism. Although the chief merit of non-reductive physicalism appears to be its ability to respect the irreducibility of mental concepts to physical concepts, whilst respecting the primacy of the physical ontology, I claim that its commitment to the principles of physicalism prevents that framework from being able to accommodate what I will refer to as the deeper extent of the autonomous nature of mentalistic explanation. The deeper extent of the autonomous nature of mentalistic explanation manifests itself in the fact that the work carried out by mentalistic explanations is completely separate from the work carried out by physicalistic explanations. I claim that the deeper extent of the autonomous nature of mentalistic explanation cannot be recognised within a metaphysical framework which claims to recognise the primacy of the physical ontology because recopsing deep autonomy requires giving up the assumption that the mental must be related to the physical in the manner appropriate to discharging such metaphysical principles. I defend the claim that we can recognise the deeper extent of the autonomous nature of mentalistic explanation if we take our successful explanatory practices as the starting point of our investigation, and only then revert to the question of how best to articulate the relation between the mental and the physical. My claim is that there is an intrinsic connection between the nature of the mental and the nature of human relationships, and I therefore suggest that the autonomous nature of mentalistic explanation ought to be understood in connection with the autonomous nature of human relationships. The basic ideas in this thesis are derived by combining features of Wittgenstein’s rule following considerations with features of John MacMurray’s approach to human relationships. On the basis of this combination, I argue for the more specific claim that there is an intrinsic connection between what it means to say that an individual has the capacity to think and what it means to say that he has the capacity to be involved in various types of human relationships. This connection is then used to develop a non-causal account of human action to challenge the physicalist ’s causal account, which will be used to support the claim that mentalistic explanations are autonomous with respect to physicalistic explanations in the deeper sense. I conclude by arguing that the considerations which put us in position to recognise the deeper extent of the autonomous nature of mentalistic explanation ought to constrain our statement of the relation between the mental and the physical, and I suggest that this statement should be consistent with the way in which mentalistic and physicalistic explanations carry out their work in our explanatory practices. I claim that individuals are subject to mentalistic explanations in so far as they have a life to live in the world with other people, and that individuals are subject to physicalistic explanations in so far as human beings are creatures whose life has a natural biological dimension. But rather than identifying the mental with the physical, and thereby compromise the deeper extent of the autonomous nature of mentalistic explanation, I suggest that this relation might be understood in terms of the fact that the mental is embedded in the dimension of human life which is constituted by the involvement of individuals in various types of relationshps with each other, and that the dimension of human life in which physicalistic explanations are operative is presupposed as the causal background which must be in place if individuals are to have such a life to live in the world.

I argue in this thesis that Aristotle’s hylomorphic metaphysics, supported by his theory of causality and his theory of the soul (De Anima), holds the key to solving the problem of mental causation in contemporary philosophy of mind. A core aspect of the contemporary mind-body problem is the problem of mental causation (how does the mind interact with the body to cause actions in humans). Without mental causation, in the realist sense of the word, it is difficult to see how humans are held responsible for their actions. There have been different approaches to solving the mind-body problem, but each has met with its own set of problems, except, I argue, Aristotle’s hylomorphism. Jaegwon Kim argues that Davidson’s anomalous monism cum supervenience renders mental causation epiphenomenal, and that a mental state is causally efficacious only when reduced to the physical properties. I argue that it is the phenomenal consciousness that accounts for our actions, and while neither Davidson’s nor Kim’s accounts of action can adequately deal with phenomenal consciousness, Aristotle’s metaphysics can. I argue that the ancient and neo-Aristotelian notion of self-knowledge is akin to our contemporary notion of phenomenal consciousness and that Aristotle saves the notion of autonomous mental causation through his theory of hylomorphism that holds every substance is a composite of matter (body) and form (soul). My thesis is thus a novel invitation to rethink Aristotle’s psychology and philosophy of mind in the context of contemporary philosophy of mind. / Thesis (DPhil)--University of Pretoria 2020. / University of Pretoria(Postgraduate Bursary (2017-2018) / Philosophy / DPhil / Unrestricted

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Let G be a reductive algebraic group defined over an algebraically closed field of characteristic p. A subgroup H of G is called G-complete reducible whenever H is contained in a parabolic subgroup P of G, it is contained in some Levi subgroup of P. In this thesis, we present a pair of reductive subgroups H and M of G of type E_7 such that H<M and H is G-completely reducible but not M-completely reducible.

The purpose of this research was to investigate the microorganisms, genetics and biochemistry of anaerobic dechlorination of chlorinated ethanes, which are common groundwater contaminants. Specifically, this project used mixed microbial cultures to study the dechlorination of 1,2-dichloroethane (1,2-DCA), 1,1,2-trichloroethane (1,1,2-TCA) and 1,1,1-trichloroethane (1,1,1-TCA). A mixed microbial culture enriched from a contaminated multilayered aquifer in West Louisiana dechlorinated 1,2-DCA, 1,1,2-TCA, tetrachloroethene, trichloroethene, cis-dichloroethene and vinyl chloride (VC) to non-toxic ethene when amended with ethanol as the electron donor. 16S rRNA gene sequence analysis revealed the presence of the putative dechlorinating organisms Dehalobacter and Dehalococcoides spp. Denaturing gradient gel electrophoresis analysis and quantitative PCR (qPCR) with species-specific primers demonstrated that both organisms grew during the dichloroelimination of 1,2-DCA to ethene. Conversely, during the dichloroelimination of 1,1,2-TCA to VC only Dehalobacter grew, while during the reductive dechlorination of VC to ethene only Dehalococcoides grew. Further enrichment with 1,2-DCA, H2 and acetate yielded a co-culture of Dehalobacter and Acetobacterium spp. that did not dechlorinate other chlorinated ethanes or ethenes. Dehalobacter grew in the presence but not in the absence of 1,2-DCA, while Acetobacterium growth was not affected by 1,2-DCA. A novel putative Dehalobacter-associated 1,2-DCA reductive dehalogenase gene was identified and was shown to be transcribed only in the presence of 1,2-DCA. An enrichment microbial culture derived from a 1,1,1-TCA-contaminated site in the northeastern United States was also studied. This culture, referred to as MS, reductively dechlorinated 1,1,1-TCA to 1,1-dichloroethane (1,1-DCA) and then to monochloroethane (CA) when amended with methanol, ethanol, acetate and lactate. 16S rRNA gene sequence analysis revealed the presence of the putative dechlorinating organism Dehalobacter sp., whose growth during 1,1,1-TCA and 1,1-DCA dechlorination was confirmed by qPCR. In the presence of chlorinated ethenes, dechlorination 1,1,1-TCA by the culture MS was slowed, while dechlorination of 1,1-DCA was completely inhibited. Experiments with cell-free extracts and whole cell suspensions of culture MS suggested that chlorinated ethenes have direct inhibitory effects on 1,1,1-TCA reductive dehalogenase(s), while the inhibition of 1,1-DCA dechlorination may be due to effects on non-dehalogenase components of Dehalobacter sp. cells. Additionally, two novel reductive dehalogenase genes associated with 1,1,1-TCA reductive dechlorination were identified.

Thesis advisor: James P. Morken / This dissertation describes the development of two enantioselective methods of carbon-carbon bond formation. Chapter one discusses the development of an enantioselective Pd(0)-catalyzed conjugate addition of allylboronic acid pinacol ester to &alpha;,&beta;-unsaturated methylidene ketones. Utilizing the same rationale for regio- and enantiocontrol as in the related enantioselective conjugate allylation of arylidene ketones, this method addresses the gap in technology by expanding the scope of the reaction to include alkyl-substituted enones. Chapter two examines the coupling of allyl electrophiles and allyl metal reagents. With computational insight into the reaction mechanism, a catalyst system was designed to control regioselectivity and enantioselectivity. Isotope labeling studies were carried out to probe the mechanism of the transformation. The reaction also proves to be diastereoselective when a substituted allyl boron reagent is employed. / Thesis (PhD) — Boston College, 2011. / Submitted to: Boston College. Graduate School of Arts and Sciences. / Discipline: Chemistry.