München, Techn. Univ., Diss., 2004.

Thesis (M.S.)--Oregon State University, 2008. / Printout. Includes bibliographical references (leaves 29-32). Also available on the World Wide Web.

Thesis (Ph. D.)--University of Chicago, 1922. / "Private edition, distributed by the University of Chicago libraries, Chicago, Illinois." "Reprinted from the Biological bulletin, vol. XLIV, no. 3, March, 1923." Bibliography: p. 151-152. Also available on the Internet.

Thesis (Th. M.)--Grace Theological Seminary, 1979. / Includes abstract. Includes bibliographical references (leaves [99]-106).

Thesis (PH. D.)--University of Chicago, 1915. / "A Private edition distributed by the University of Chicago Libraries." "Reprinted from the Journal of experimental zoölogy, vol. 20, no. 2. February, 1916." Bibliography: p. 161-163. Also available on the Internet.

Thesis (PH. D)--University of Chicago, 1921. / "Author's abstract of this paper issued by the [Wistar institute] Bibliographic service, May 1." "Private edition, distributed by the University of Chicago libraries, Chicago, Illinois." "Reprinted from the Journal of experimental zoology, vol. 36, no. 1, July, 1922." Bibliography: p. 46-47. Also available on the Internet.

No description available.

Acute liver failure confers a high risk of death, with liver transplantation offering the only effective therapy for life-threatening cases. Hepatic macrophages are crucial for innate immune integrity and effective hepatocyte proliferation. The macrophage may therefore present a novel therapeutic target to enhance regeneration following acute liver injury. In this thesis I describe the development and use of mouse models of liver injury including partial hepatectomy, partial hepatectomy plus chronic liver injury and paracetamol intoxication. I show the development of liver function assays in these models including quantification of hepatic clearance of indocyanine green by fluorescent imaging and assessment of hepatic phagocytic capacity using fluorescent microbeads. I then describe macrophage based therapeutic interventions in mouse models of liver injury. Firstly the direct administration of bone marrow derived macrophages in partial hepatectomy plus chronic liver injury. I then tested the administration of macrophage colony stimulating factor in mouse models of partial hepatectomy, partial hepatectomy plus chronic liver injury and paracetamol intoxication, describing the phenotype and exploring mechanisms of action. Collaborating with others I assessed serum CSF1 levels in humans with liver injury due to partial hepatectomy or paracetamol intoxication. I show that in acute liver failure a high serum CSF1 level is predictive of survival, indicating a new mechanistic biomarker.

Over the last decade, the concept of using sport for regeneration purposes has gained increasing credibility in a number of cities throughout the UK. Despite this, little is known about the economic importance of sport at the local level. Although research has been carried out on the economic activity generated through sport since the mid 1980s (Henley Centre for Forecasting, 1986), the majority of studies have been undertaken at the national and regional level. This thesis investigates the economic importance of sport at the local level, using Sheffield as a case study. It represents the first study of sport-related economic activity to be carried out at the city level, in the UK. Following a critical evaluation of the feasible methodologies for measuring the economic importance of sport at the local level, the National Income Accounting framework was found to be most appropriate for measuring sport-related economic activity in Sheffield. To satisfy the data requirements of this framework, extensive primary data collection was undertaken in the voluntary, consumer and commercial sport sectors using questionnaires and structured interviews. This was used, together with data collected from secondary sources and previous economic impact studies in the UK, to estimate the value-added and employment created from sport-related economic activity in Sheffield. The findings of the research revealed that the economic importance of sport in Sheffield in 1996/97 was approximately twice the level predicted from current national estimates. The value-added by sport-related economic activity was found to be £165.61 million, which was approximately 4.11% of GDP in Sheffield in 1996/97, compared with just 1.61% of GDP at the national level (LIRC, 1997). Whilst a number of explanations for these findings are explored within the thesis, one of the most significant findings of the research is that previous estimates, established in other studies on the economic importance of sport in the UK, have been inaccurate and have essentially underestimated the size of the sport-related economic activity. The research also evaluated the potential role for sport in economic regeneration and provided evidence to suggest that sport can perform as a basic sector activity, a function widely assumed to be fulfilled only by producer services, manufacturing and agricultural activities (Williams, 1997). The study demonstrates that sport is an industrial sector within its own right and that it has considerable potential for generating benefits, including local economic development, job creation and urban renewal. Nevertheless, the thesis suggests that the future development of the sports industry for regeneration purposes should take the form of an integrated approach with other cultural industries and tourism.

The study proposes to operationalise sustainable development within an urban environment and at a variety of scales - strategic to neighbourhood. The study examines the convergence of ideas within urbanity and sustainability, identifying inconsistencies and contradictions within current thematic research. It proposes a consensual approach to understanding the linked substantive, analytical and procedural attributes underlying a developing chronology of concepts relating to sustainability. This chronology of ideas provides the basis for a systems-based framework that recognises the complexity of urban areas. The study advocates and introduces an adaptive framework of spatial indicators of urbanism to simplify and communicate an holistic overview of attributes of sustainability. This interpretation of holism is based on thematic (qualitative / quantitative) and scalar (strategic / local) based integration on a consistent (spatial) basis. This adaptive framework is designed to be suitable for locality specific subjective interpretations of sustainability. It is linked to a non-expert methodological 'toolkit' that places an emphasis on currently undervalued qualitative and spatial data collection methods. This is a mixed and multi- method approach to understanding spatial (urban) systems that complements empirical data sets. A series of case studies are used to test and refine qualitative collection from primary and secondary sources and spatialisation methods. Sample material is then used to test the utility and ease of use of GIS for data manipulation, analysis and modelling. Two detailed and complementary applications of the adaptive framework, the data inventory / collection methods and the use of GIS based digital spatial databases are used to illustrate the potential range of applications and highlight problems of use. A number of possible future developments of the study are suggested for maximising the utility of the conceptual approach and a developed spatial database for a variety of agents, exploring additional dimensions of the urban system.