Masters of Science / Background: In Africa, traditional medicine (TM) practice has been in existence since time immemorial as the major source of pharmacotherapy. However, unlike orthodox medicines TM policies and regulations are not formalised let alone standardised. African nations have different approaches and regulatory requirements whereas in some states policies are even non-existent. Aim: The aim of the mini thesis was to assess the current policies and guidelines for regulation of TM in five selected sub-Saharan African countries relative to the WHO recommendations on traditional medicine policy. Method: The mini thesis was a desk review of current policy frameworks and guidelines for regulation of traditional medicines relative to WHO recommendations on TM policy in sub- Saharan Africa using five selected countries. Result: The results from the five selected countries showed significant difference in the current policies and guidelines on the regulation of TM, but no significant difference in the actual WHO TM policy indicators that the countries implemented. Discussion: Regularisation of TM practice by integrating it into main health systems could make it more acceptable. The complexity of TM/herbal products needs a different yet integrated approach. Harmonisation of regulatory requirements eliminates the need for redundant testing, ensures consistency across regions and improves implementation of WHO TM policy indicators.