Self-handicapping has been conceptualized as an identity-based strategy motivated by impression management and, more recently, as an avoidance coping strategy. However, additional evidence suggests that self-handicapping can provide a short-term performance boost (with detriments accruing over the long-term). I use a resource conservation perspective to suggest that this boost in performance may be attributed to an individual's motivation to conserve resources, particularly when there is reason to believe that resources spent now may be better used later. The current study tests if handicapping situations (similar to ones created following the choice to self-handicap) encourage an individual to conserve their resources (e.g., reducing effort), allowing them to spend those resources on later tasks. It was hypothesized that individuals in a handicapping situation would show greater resource conservation (evidenced by decreased effort) as well as improved performance on a follow-up resource-dependent task, compared to those not in a handicapping situation. Additionally, I hypothesize that individuals in a handicapping situation will show greater conservation and greater subsequent performance on a resource-dependent task when there is anticipation for that follow-up task. Effort was also hypothesized to mediate the relationship between group assignment and subsequent performance differences. Finally, it was hypothesized that these relationships would be moderated by neuroticism, conscientiousness, and self-handicapping tendencies (traditional moderators of SH). Prior to an in-lab study, participants (N = 162 undergraduates) completed on-line measures of self-handicapping (SHS), neuroticism, and conscientiousness. Participants were then brought to the lab individually for a study supposedly testing the effects of sound on performance. They were randomly assigned to one of three groups differing in the information given regarding: (1) the level of distraction a stimulus would produce and (2) whether a follow-up task was anticipated after the noise-based task (i.e., Distraction-Anticipation, Distraction-No Anticipation, No Effect-Anticipation). All participants were first given a series of geometric tracing designs allegedly assessing their spatial reasoning ability (series contained 4 solvable designs and 2 impossible designs) and were provided with noncontingent success feedback. Then, participants were asked to complete a new series of tracing designs (eight solvable, one impossible) while a tone was playing. Participants in the distraction conditions (i.e, Distraction-Anticipation and Distraction-No Anticipation) were led to believe that the tone had the ability to significantly impair performance, while participants in the No Effect condition believed the tone had no impact on performance. Following this task, all participants were given a series of logic questions that served as an assessment of regulatory depletion. Results supported the two primary hypotheses. When participants believed that the tone was distracting, and when they anticipated a third task, they were more accurate on the part three logic task (F(2,159) = 7.69, p<.01) compared to both those in the No Effect-Anticipation and the Distraction-No Anticipation conditions. The relationship between group assignment and part three logic performance was mediated by effort during part two (quitting r2 = .14; F(2, 105) = 8.43, p<.001; indirect effect b = -.05, SE = .03, 95% CI [-.12, -.01]). No theoretically meaningful moderators were found. The findings provide initial evidence for resource conservation as a new and unique motivation for self-handicapping. Implications for future research are discussed. / Ph. D.

Emotion regulation difficulty is commonly experienced by autistic adults and has been explored as a transdiagnostic mechanism contributing to anxiety and depression in autistic adults. Previous research has found that emotion regulation strategies and autonomic nervous system (ANS) responses involved in emotion regulation differ between autistic and non-autistic individuals. These findings highlight the role of the ANS as a measure of emotion regulation; however, this has not been studied in an autistic adult sample. The current study examined ANS activity, as measured by respiratory sinus arrhythmia (RSA), root mean square successive differences (rMSSD), and skin conductance level (SCL), and subjective ratings of valence and arousal at rest and while viewing emotional film clips and engaging in emotion regulation in autistic adults. The study consisted of 31 autistic and 31 non-autistic adults, matched on age, intellectual ability, sex, and race/ethnicity. Participants also self-reported their daily emotion regulation use via the Emotion Regulation Questionnaire. Results demonstrated group differences in baseline RSA and rMSSD, self-reported valence of viewing neutral and negative stimuli, and cognitive reappraisal used in daily life. There was also increased SCL and self-reported arousal and decreased self-reported valence to negative stimuli across the whole sample. Exploratory results also showed that SCL and self-reported arousal to negative stimuli were correlated for autistic participants, and that emotion regulation changed physiological and subjective experiences of negative emotion across the whole sample. Supplementary analyses explored the covarying role of co-occurring depression and anxiety and antidepressant use, and showed that these covariates may explain variance in some physiological and self-reported responses whereas in other models, they may suppress these changes. This study extends previous research on emotion regulation in daily life of autistic adults and is the first investigation that demonstrates how an objective measure, such as correlates of ANS, provides additional insight in emotion regulation in autistic adults beyond subjective ratings. This study is important insofar as it shows how emotion regulation strategies manifest in autistic adults and its implications for informing the use of emotion regulation treatment intervention. / Doctor of Philosophy / Autistic adults struggle to regulate their emotions which may contribute to their anxiety and depression. It is previously known that autistic people emotionally regulate differently than non-autistic people, and that their autonomic nervous system (ANS) reacts differently too. These differences may lead to information about how the ANS may measure emotion regulation, yet no one has ever studied this in autistic adults. Therefore, the following study examined ANS activity, as measured by respiratory sinus arrhythmia (RSA), root mean square successive differences (rMSSD), and skin conductance level (SCL), and self-reported ratings of positivity and excitement at rest and while watching emotional film clips and regulating their emotional responses in autistic adults. The study included 31 autistic and 31 non-autistic adults, who had similar age, intellectual ability, sex, and race/ethnicity. Participants also self-reported how often they emotionally regulated, specifically by changing their thoughts ("reappraisal") and keeping a blank face ("suppression") in their daily life using the Emotion Regulation Questionnaire. Based on this study, autistic adults had lower levels of RSA and rMSSD when they were watching a baseline video of swimming fish. They also rated lower levels of positivity when watching both neutral and negative themed film clips and shared that they used reappraisal less frequently in daily life than non-autistic adults. Everyone in the study showed increased SCL and rated lower levels of positivity when watching negative themed film clips. Also, autistic adults with higher SCL also felt greater levels of excitement when watching negative film clips. For everyone, regulating emotional experiences changed the body's responses (i.e., RSA, rMSSD, and SCL) and experiences of positivity and excitement when watching negative themed film clips. However, since having depression and anxiety and taking antidepressants may affect how participants emotionally regulate, additional analyses also explored the impact of these factors; these extra analyses found that some of the previously reported findings may be because of depression, anxiety, and antidepressants, rather than being autistic. Overall, this is the first study to explore the relationship between emotion regulation and autism in adults by looking at the ANS. It is important because it shows how autistic people emotionally regulate which can help experts design mental health treatments.

The ability to collaborate has been identified as an essential learning outcome for the 21st century. However, if group members lack the skills, abilities, and attitudes to work in a team, these groups may work inefficiently or fail to achieve what they set out to do. To achieve success, group members need to engage in productive regulatory processes to manage cognitions, behaviors, motivation, and emotions as needed to attain desired outcomes. One area of regulation that has been underemphasized in collaborative contexts is the regulation of emotions. Therefore, the purpose of this multi-paper dissertation was to examine the emotional experiences of undergraduate students working collaboratively on two online time-limited problem-solving tasks. Using a regulation of learning framework, the research unfolded over four studies drawing from a variety of data sources and building upon one another to explore the socio-emotional aspect of online collaboration. Study 1 (Webster & Hadwin, 2018) provides an overview of students’ emotions and plans for emotion regulation, self-reported during two collaborative tasks, offering an in-the-moment picture of how students feel and how they respond to those feelings. Study 2 (Bakhtiar, Webster, & Hadwin, 2018) consisted of a comparative case study to examine differences in regulation and socio-emotional interactions between two groups with contrasting socio-emotional climates. Findings revealed differences between these groups in terms of planning and preparation; therefore, the final two studies examined emotions and emotion regulation strategies reported during groupwork under different levels of planning and preparation at the individual or group level. Study 3 (Webster & Hadwin, 2019) documented the types of strategies students recalled using individually and as a group to regulate a salient emotion during collaboration and compared strategies between groups who were given different types of collaborative planning support. Finally, Study 4 (Webster, Davis, & Hadwin, 2019) compared emotions, emotion regulation strategies, and evaluations of strategy effectiveness for a purposeful sample of students who were well-prepared versus underprepared for the first of two collaborative working sessions. Four overarching factors emerged from this research as important for productive emotion regulation in online collaboration: (a) planning and preparation, (b) regulating both negative and positive emotions, (c) regulating at both individual and group levels, and (d) providing support for selecting and enacting helpful strategies. With further research, tools and interventions can be improved and utilized to support students to productively regulate in collaborative groups. / Graduate

1. There are two major pieces of work (the Code Review and Sutton) and a number of themes that are the subject matter for this submission. The Insurance Council of Australia appointed me as the Independent Reviewer of the General Insurance Code of Practice, under the Code and the Terms of Reference, on 3 May 2012. 2. The Code Review work took about two years and involved the Code Issues Paper in October 2012 of 111 pages and the Code Review Report in May 2013 of 205 pages. The majority of my recommendations were accepted and the report has made a contribution to the rethinking of self-regulation and the place of voluntary codes in financial services. By then I was writing, with Professor Robert Merkin QC Sutton on Insurance Law for its 4th Edition. It is two volumes, 24 chapters and about 2100 pages excluding tables and index; my contribution was 12 chapters totalling about 960 pages. 3. The Code Review work, particularly on government agency regulation and self-regulation, influenced the pervasive material in Sutton on regulation. It was the subject of the AIDA Rome paper in 2014 on Principles for Self-Regulation; the paper was published by AIDA. 4. Sutton was published in 2015. Its themes are set out below. Those themes are in turn influences in the other work for this submission. There are seven main themes in the publications which I present in this submission. 5. The historical influences in relation to my Code Review and the historical contextual material in Sutton stimulated my interest in the wider influences on the development of commerce, insurance and law, with a central interest in the ethical foundations of the law and regulation. This aspect was also developed in the Masel Lecture and the article William Murray, Lord Mansfield: His Life, Times and Legacy – Good Faith and Good Works. 6. There had been a number of issues raised in my Code Review about mental illness, insurance and discrimination. I spoke at AIDA in Rome 2014 on Insurance Discrimination Law and the paper was published by AIDA. Then in 2016, the Australian Centre for Financial Studies commissioned me to write the ACFS MID Paper on the use by insurers of mental illness data. The historical perspective and the regulatory framework were important features of both papers. 7. A number of the Sutton themes were first opened out in my Professional Indemnity Insurance Law. The main themes were, in decreasing order of connection with Professional Indemnity Insurance Law, as follows. The first theme is the identification, development and application of the indemnity principle. The second is the adaptation and application of the analysis of contracts by primary and secondary obligations. This theme is in Sutton on the main concepts in insurance as well as liability insurance issues. The Liability Disputes Chapter condenses this thinking and account. The third theme was a renovation of how life insurance issues should be analysed and presented. This life insurance material was then adapted and infused with practical guidance on the decision making process on some issues for the FOS Life Insurance Manual. I developed an aspect of life insurance in the TPD Article. Each of these themes are in my submission original in concept and execution. Each has influenced the development of the law by legisation and the courts.

"Host resolution of viral infection is dependent upon components of the innate and acquired immune system. The mammalian protein Apobec3 plays an important role as part of the immune system’s innate defenses through its modification of reverse transcribed viral DNA. Recently, Apobec3 was found to directly inhibit HIV-1 and HBV replication through deaminating newly transcribed deoxycytidine residues to deoxyuridine. The ability of mouse and simian Apobec3 variants to inhibit human retroviruses and vice versa highlights the utility of analyzing cross-species homologues. To better understand this editing enzyme, differentially pathogen-susceptible inbred mice were used as an experimental model. The purpose of this project is to examine the effects of murine Apobec3 (muA3) alternative splicing on its DNA-editing characteristics. Three distinct Apobec3 isoforms were isolated from pathogen-susceptible BALB/cByJ (“C”) inbred mice, and two Apobec3 isoforms came from pathogen-resistant C57BL/6ByJ (“Y”) mice. The five muA3 isoforms were cloned, sequenced, and expressed from a constitutive promoter in a haploid Saccharomyces cerevisia strain. MuA3 DNA-editing activity was measured via the CAN1 forward mutation assay. The five isoforms studied in this project were discovered to be strain-specific. One isoform from each mouse strain mutated the yeast CAN1 locus significantly. Additionally, both muA3 isoform mRNAs derived from the pathogen-resistant Y mice were found to persist at a higher level (2.7 -12.4 fold) than any of the C mouse isoforms. This suggests that the absence of exon 5 or some other signal in the Y mice may influence transcript stability. Evidence also suggests that the murine Apobec3 start codon is actually 33bp upstream of its reference start, with implications for previous research performed using muA3. Sequencing analysis of genomic DNA revealed the presence of a 4bp insertion in a region of BALB/cByJ muA3 which may have disrupted an intronic splicing enhancer signal. Furthermore, a novel BALB/cByJ Apobec3 isoform was characterized. This is the first report of strain-specific processing with regard to muA3."

This thesis proposes to determine the role of regulation that promotes competition in the telecommunications market in Chile. Regulation has been used in the telecommunications sector at different points in time to fulfil various market needs. Before liberalisation of the telecommunications market, regulation established the parameters of the state-owned telecommunications company. Later, regulations specified the rights and duties of the incumbent. Hypothetically, a higher degree of regulation is necessary to develop new markets, and once progress has been made, a lesser degree of rules is required. This heavier regulation has been called 'regulation for competition', ‘regulatory competition law’ or 'synthetic competition'. Instead, this research proposes the concept of ‘emulated competition’, which is useful to clarify the role of regulation as a mechanism to promote competition. To build the concept of ‘emulated competition’, the thesis reviews the relationship between sectoral regulation and competition law from a theoretical viewpoint. Subsequently, the thesis carries out a comparative analysis between the United States (US) and the European Union (EU) regarding the treatment of certain abuse of dominance cases, particularly with regard to ‘margin squeeze’. To study the Chilean model, the research reviews the constitutional framework of economic regulation and competition law, examining the evolution of pro-competition regulatory tools since the beginning of privatisation. Furthermore, the thesis analyses the case law and regulation issued by the Chilean competition authority in the same period. The analysed topic allows a review of how emulated competition operates in Chile. To sum up, competition law alone is not the best way to introduce competition in the telecommunications market. Therefore, sector-specific regulation has been used to promote competition. In some jurisdictions, it works together with competition law, such as in the EU and Chile. In others, they are incompatible, such as the US. Emulated competition rules could have a higher impact on competition law when they are complements. The research also proposes a model for considering non-economic objectives in competition law matters, and it is a breakthrough in the debate of how to incorporate them in such situations. Finally, the emulated competition concept provides a systematic way of dealing with the intended and unintended effects of pro-competition regulatory tools. The concept itself summarises the contribution to the literature.

The topic of my thesis is An Employment Notice, comparing Czech and German regulation. The purpose of the thesis is to describe and to analyse an employment notice according to Czech Labour Codex and German Labour statutes. First chapter presents legal principals. Second chapter is to consider the role of international organisations and the European Union within in the context of an employment notice. In next one types of employment termination are introduced, for instance an agreement on employment termination, the institute of an employment notice, termination due to employee's death and an employment termination of fixed period. Following chapter is crucial one for the aim of my thesis. It is divided into several parts which deal with reasons of employment termination by an employer, types of an employment notice, delivery, grounds of employment notice, notice periods, and a protection against an employment notice. That chapter also contains comparison of Czech and German law. Next part of my thesis is to be concerned with collective dismissal in Czech and German regulation. In my conclusion I summarize essential differences between both national regulations and try to outline suitable regulation legal arrangement of an employment notice "de lege ferenda".

Psychological conditions, including stress, compromise immune defenses. Although this concept is not novel, the molecular mechanism behind it remains unclear. Neuropeptide Y (NPY), regulates anxiety and is a part of the stress response. The NPY system also modulates immune functions such as cytokine release, cell migration, and innate immune cell activity. Postganglionic sympathetic nerves innervating lymphoid organs release NPY, which together with other peptides activate five receptors (Y1, Y2, Y4, Y5, and y6). Additionally, immune cells themselves release NPY following activation. Previous studies have shown that Y1 mediates NPY-immune effects and data presented here shows expression of Y1 on a wide range of immune cells. Results presented in this thesis, using Y1-deficient mice (Y1-/-), have uncovered a novel role for Y1 on immune cells. NPY acts endogenously to inhibit T cell activation whereas Y1-/- T cells are hyper-responsive to activation and trigger severe colitis after transfer into lymphopenic mice. Thus, signalling through the Y1 receptor on T cells inhibits T cell activation and controls the magnitude of T cell responses. Paradoxically, in Y1-/- mice, T cell differentiation to Th1 T cells appears to be defective as these mice were resistant to T helper type 1 (Th1) cell???mediated inflammatory responses and showed reduced levels of the Th1 cell???promoting cytokine interleukin 12 and reduced interferon ?? production. This defect was due to functionally impaired antigen presenting cells (APCs). Y1-deficient APCs are defective in their ability to produce Th1-promoting cytokines and present antigens to T cells and consequently, Y1-/- mice had reduced numbers of effector T cells. Key reciprocal bone marrow chimera experiments indicated that this effect is intrinsic to immune cells and not driven by other Y1-expressing cell types. These results demonstrate a fundamental bimodal role for the Y1 receptor in the immune system, serving as a strong negative regulator on T cells as well as a key activator of APC function. The findings presented in this thesis uncover a sophisticated molecular mechanism regulating immune cell functions and thus adds to a growing number of signalling pathways shared by the immune and nervous system.

La famille des protéines SIBLINGs comprend la sialoprotéine osseuse (BSP), lostéopontine (OPN), la sialophosphoprotéine de dentine (DSPP), la protéine de matrice de dentine 1 (DMP1), la phosphoglycoprotéine de matrice extracellulaire (MEPE) et lénameline (ENAM). Comme leur nom lindique, ces protéines ont dabord été identifiées au niveau de la matrice minéralisée de los et de la dent. Durant la dernière décennie, notre Laboratoire et dautres équipes ont démontré que cette famille de protéines est également exprimée par un certain nombre de tissus tumoraux. Nous avons entrepris ce doctorat dans la continuité des projets de recherche menés au Laboratoire sintéressant à létude des SIBLINGs au cours de la progression tumorale et métastatique. La première partie de notre projet a consisté à investiguer les mécanismes de régulation de lexpression du gène de la BSP humaine au niveau de cellules ostéoblastiques. Le facteur de transcription Runx2 est un facteur clé de la régulation des gènes osseux. Dès lors, nous avons émis lhypothèse selon laquelle linduction de lexpression du gène de la BSP observée au cours de la différenciation ostéoblastique pourrait être sous la dépendance de ce facteur. Nous avons ensuite étudié la régulation du gène de la BSP au niveau de cellules cancéreuses mammaires. En effet, nous avons voulu déterminer si lexpression de la BSP était sous la dépendance de mécanismes de régulation transcriptionnelle différents de ceux observés au niveau de cellules dorigine osseuse. Lobjectif final étant de bloquer spécifiquement lexpression de la BSP au niveau des tumeurs. Notre stratégie a dabord consisté à identifier les principaux facteurs transcriptionnels impliqués dans cette régulation puis à en étudier limpact sur lactivité du promoteur de la BSP au niveau des deux types cellulaires considérés. Dans la deuxième partie de ce projet, nous nous sommes consacrés à létude dun autre membre de la famille des SIBLINGs, lOPN, afin den identifier le rôle au niveau des gliomes humains. Précédemment, il a été démontré que lOPN est surexprimée dans les gliomes et ce, en corrélation avec le grade de la tumeur. Cependant, il ny a que peu détudes décrivant le rôle de lOPN dans les gliomes. Dès lors, nous avons voulu vérifier limportance de lOPN au cours du développement des gliomes en utilisant la technique dinterférence à lARN.

This paper argues in favour of principle-based securities regulation for Canada. The author examines the current state of Canadian securities regulation and why change is needed. The author then examines the characteristics of principle-based regulation and contrasts it against rule-based regulation while exposing the advantages and disadvantages of both regulatory models. In proposing a principle-based model for Canadian securities regulation, the author looks to the use of this type of regulation in the capital markets of certain Canadian provinces, the United States and the United Kingdom and then examines certain attributes of Canadian capital markets that have to be considered in the application of principle-based securities regulation to Canada. In supporting principle-based regulation as the modern form of securities regulation, the author discusses lessons learned from the global financial crisis and how those lessons can be applied in the promotion of principle-based securities regulation for Canada.