In recent decades, research on family life and religion has been conducted. Much of the research done on religion and well-being has shown beneficial effects of religion or religious practices on well-being (Bonner, Koven, & Patrick, 2003; Loser, Klein, Hill, & Dollahite, 2008). Using data from the Flourishing Families Project (N = 359 adolescents), the relationship between religious variables (family religious practices, family religious importance and religiosity), family climate measures (family connectedness and parent conflict) and adolescent depressive symptoms was examined. Results indicate no significant relationship between religious variables and adolescent depressive symptoms, but a positive relationship between parent conflict and adolescent depressive symptoms and a negative relationship between family connectedness and adolescent depressive symptoms. These findings suggest that while family climate is important to adolescent depressive symptoms, religious activity as measured by family practices is not protective.