Rift Valley Fever is a zoonotic, arthropod-borne disease that adversely affects ungulates and people. The etiologic agent, Rift Valley fever virus (RVFV; Bunyaviridae, Phlebovirus), is primarily transmitted through mosquito bites, yet can be transmitted by exposure to infectious aerosols. Presently, there are no licensed vaccines or therapeutics to prevent or treat severe RVFV infection in humans. We have previously reported on the activity of favipiravir (T-705) against the MP-12 vaccine strain of RVFV and other bunyaviruses in cell culture. Additionally, efficacy has been documented in mouse and hamster models of infection with the related Punta Toro virus. Here, we characterize a hamster RVFV challenge model and use it to evaluate the activity of favipiravir against the highly pathogenic ZH501 strain of the virus. Subcutaneous RVFV challenge resulted in substantial serum and tissue viral loads and caused severe disease and mortality within 2-3 days after infection. Oral favipiravir (200 mg/kg/day) prevented mortality in 60% or greater in hamsters challenged with RVFV when administered within 6 h post-exposure and reduced RVFV titers in serum and tissues relative to the time of treatment initiation. In contrast, although ribavirin (75 mg/kg/day) was effective at protecting animals from the peracute RVFV disease, most ultimately succumbed from a delayed-onset neurologic disease associated with high RVFV burden in the brain observed in moribund animals. When combined, T-705 and ribavirin treatment started 24 h post-infection significantly improved survival outcome and reduced serum and tissue virus titers compared to monotherapy. Our findings demonstrate significant post-RVFV exposure efficacy with favipiravir against both peracute disease and delayed-onset neuroinvasion, and suggest added benefit when combined with ribavirin.

<p> The opening of the Rio Grande Rift of Southern Colorado resulted in a wide variety of igneous features including the Spanish Peaks dual stocks, their surrounding radial dyke system and several proximal enigmatic plugs.</p> <p> Aspects of the crystallization history of two magmas have been studied by using petrographic observations and Crystal Size Distribution (CSD). These were used to examine opaques and feldspars from a rhyolitic dyke in the Spanish Peaks swarm and augite, olivine, and opaques from a gabbroic dyke within Huerfano Butte.</p> <p> Augite and opaques from Huerfano Butte reveal a history of no crystal fractionation during emplacement, no size dependent growth, and constant, continuous nucleation and growth.</p> <p> Huerfano Butte olivine and Spanish Peaks opaques have been subjected to resorption and depletion of nucleii. The resorbed olivine material was probably redeposited as augite. This could explain why Huerfano Butte augite has a much higher nucleation density than the other minerals.</p> <p> The phenocrystic feldspars from Spanish Peaks also have a deficit of nucleii, but they lack resorption features. Xenocrystic skeletal feldspars throughout the dyke lack a fines population and show resorption. The absence of fines is probably due to sorting of grains by density during magma convection before eruption.</p> / Thesis / Master of Science (MSc)

<p> The Rio Grande Rift is a major tectonomagmatic feature of the North American craton. Physiographically, the present rift is recognized as a series of grabens and half-grabens which extend for over 1000 km from south-central Colorado into Chihuahua, Mexico. Rift structures, however, are recognized as far north as the Colorado-Wyoming border. Basaltic magmatism within the rift began by 30 Ma in southern New Mexico, and by 25 Ma in northern New Mexico and Colorado. Within-rift magmatism is low in volume in comparison to rift-related activity on the rift shoulders and flanks. </p> <p> Petrologic studies of Rio Grande Rift-related volcanics are numerous, yet focus primarily on suites erupted in north-central New Mexico and Colorado. However, recently published abstracts suggest areas of southern New Mexico are receiving much needed attention. Initial attempts at characterizing the petrologic diversity and mantle sources of rift-related volcanics have concentrated on major and trace element data, as well as the application of Sr and Nd isotopes. Only minor attention has been given to Pb isotope variations. </p> <p> This thesis contains the most recent compilation of Pb isotope data for volcanic rocks erupted within the Rio Grande Rift region. The oldest rocks included in this work are· monzonite stocks erupted c. 60 Ma within the Colorado Mineral Belt. Using Pb isotope data in combination with trace element variations and Sr-Nd isotopes, a model is developed which suggests the stocks were initially derived from mantle sources with geochemical properties similar to those which produced rift-related basaltic volcanics in northwest Colorado beginning at 25 Ma. </p> <p> Two chapters of the thesis are devoted to exploring the utility of Pb isotopes as tracers of crustal influence in continental basaltic volcanism. One deals specifically with documenting Pb isotope variations in the northwest Colorado region, whereas the second focuses on variations in the Espanola Basin of north-central New Mexico. Major results of the northwest Colorado study 1) suggest that the asthenosphere contributed to early rift (25 Ma volcanism), 2) better characterize the geochemical signature of lithospheric and asthenospheric sources during periods of active volcanism, and 3) confirm earlier suspicions regarding the effects of crustal contamination in several rock suites. Work on basaltic components of volcanism in the Espanola Basin indicate that crustal contamination was also an important process in producing the observed Pb and Sr isotopic variations in both early and later rift lavas. </p> <p> The remaining chapter of the thesis is a synthesis of all available rift data, from northern Colorado to southern New Mexico. An analysis of changes in the Pb isotopic corn position of the lithosphere with latitude is presented, as well as a cross-rift transect of the central rift region. Further, a model which combines previously published ideas on the tectonomagmatic development of the Rio Grande Rift and the Basin and Range province is proposed. The most important results of the combined model are the proposition that rifting began earlier than previously thought, and that the timing of extension and magmatism in the Rio Grande Rift is very similar to that of the Basin and Range province. Additional data from the rift, particularly the southern region, will help to confirm or deny this model. </p> / Thesis / Doctor of Philosophy (PhD)

No description available.

No description available.

The Triassic Cow Branch Formation of the Dan River Basin is host to a world-class lagerstätte deposit of exceptionally preserved insects, among other organisms. The lagerstätte occurs within a cyclic, lacustrine sedimentary succession, hypothesized to have been driven by Milankovitch climate forcing. Through an integrated sedimentological and geochemical investigation, I present evidence that the lagerstätte was deposited during a lake transgression, under intermittently anoxic and ferruginous conditions. Sedimentological evidence shows a deepening followed by shoaling through a broad fining and subsequent coarsening of the sedimentary units of the sequence. This transition in grain size occurs at the lagerstätte. Despite relatively quartz-rich sediments sourced to the basin, silica-content in the studied cycle is exceptionally low. The replacement of silica by the zeolite mineral analcime, coupled with primary dolomite precipitation suggests alkaline lake water. Geochemical evidence, including total organic carbon (TOC), pyrite sulfur and iron speciation data suggest anoxic, ferruginous waters. At the lagerstätte interval, TOC content increases significantly, coinciding with the presence of darker, more laminated sedimentary lithofacies. At the interval of the highest TOC content, a spike in pyrite sulfur content occurs; likely the result of slowed sedimentation. Organic carbon-to-pyrite sulfur ratios suggest however, that the lake water was sulfate-poor and the deep waters never became euxinic (anoxic, H2S-containing). Iron proxy data show that the studied portion of the Cow Branch Formation deposited under intermittent to persistent anoxic conditions. These data suggest a confluence of factors — lake transgression, combined with alkaline and anoxic, ferruginous water chemistry — created an ideal scenario that led to lagerstätte formation. / Master of Science

The Notre Dame Bay Magmatic Province (NDBMP) comprises a suite of Late Jurassic (Tithonian), rift-related alkaline mafic intrusions in north-central Newfoundland, Canada. This field-based study focuses on the Leading Tickles area, where the gabbroic Budgell’s Harbour Stock (BHS) and radial lamprophyre dykes intrude strongly folded and faulted Ordovician back-arc volcanic and sedimentary host rocks. The primary objective was to understand how pre-existing structures influenced the emplacement and post-intrusion deformation of the NDBMP. This thesis employs a comprehensive methodology, including field mapping, thin section analysis, stereographic projections, kinematic and dynamic analysis, GIS visualization, and 3D analog modelling to analyze the interactions between pre-existing structures and the NDBMP. The results reveal that lamprophyres preferentially exploited pre-existing Paleozoic Appalachian structures associated with the Iapetus Suture Zone. Furthermore, magmatic activity weakened and deformed the host rocks, leading to the reactivation of Silurian thrust faults that deformed the lamprophyres post-intrusion. Movement along Luke’s Arm Fault Zone (LAFZ) in Leading Tickles may indicate a broader reactivation of the Iapetus Suture in northern Newfoundland during the Mesozoic. The variation in lamprophyre mineralogies and the presence of numerous radial dyke clusters suggest multiple magma sources coinciding with regional antiforms. / Thesis / Master of Science (MSc) / The Notre Dame Bay Magmatic Province (NDBMP) in north-central Newfoundland features Late Jurassic alkaline mafic intrusions linked to rifting. This study examines the Leading Tickles area, where gabbroic intrusions and lamprophyre dykes intersect older Ordovician rocks. The research explores how existing geological structures influenced the placement and deformation of these magmatic bodies. Using fieldwork, microscopic analysis, and 3D modeling, the study shows that ancient Appalachian structures guided the intrusion paths, and post-intrusion fault reactivations further deformed the rocks. The findings suggest multiple magma sources and broader regional tectonic movements during the Mesozoic.

L'objectif de cette thèse est le développement d'un vaccin recombinant capripoxvirus protégeant contre la variole des ruminants, la Fièvre de la Vallée du Rift (FVR) et la Peste des Petits Ruminants (PPR) comme modèle vaccinal destiné aux pays atteints par ces infections. Une première partie de ce travail a consisté en une enquête sérologique en Tunisie pour évaluer les prévalences PPR et FVR. L'enquête menée a montré une séroprévalence PPR de 7,6% et l'absence de FVR. Le risque lié à une infection par le virus de la fièvre de la vallée du Rift n'est pas nul en raison de l'identification des vecteurs compétents Culex theileri et Culex pipiens dans les zones échantillonnées. L'élaboration du vaccin capripoxvirus FVR-PPR porte sur l'expression des gènes NSmGN-FVR et H-PPR où chacune des valences est insérée dans le site de la thymidine kinase et le site d'un analogue du récepteur à l'interleukine 8 respectivement. Le vecteur choisi pour la souche vaccinale Kenya Sheeppox-1. Bien que nos travaux aient conduit à l'obtention du capripoxvirus double recombinant, ce dernier n'a pu être purifié. L'alternative a donc été d'évaluer l'effet protecteur et l'immunogénicité induits par le simple recombinant capripoxvirus- NSmGN-FVR, qui est un produit de l'étape intermédiaire dans l'élaboration du double recombinant FVR-PPR. L'effet protecteur de notre construction a été validé par deux expérimentations chez des souris Mus m. musculus MBT/Pas, avec épreuve infectieuse. Le nombre de doses administrées, les voies d'administration ont été déterminants dans cette protection justifiée par l'obtention d'anticorps neutralisants anti-FVR. L'étude de l'immunogénicité a été réalisée sur un modèle caprin sans épreuve infectieuse, une séroconversion FVR a été observée. La lymphoprolifération et le typage des sous populations lymphocytaires ont été analysés. / The aim of this thesis was to develop a capripoxvirus based recombinant vaccine against ruminant pox, Rift Valley fever (RVF) and peste des petits ruminants (PPR) considered as a vaccine model for countries affected by these infections. The first part of the work consisted in a serological survey conducted in Tunisia to detect the PPR and RVF presence. A PPR seroprevalence of 7.6% has been found and no antibodies against RVF were detected. However, the risk of infection with rift valley fever virus persists since competent vectors such as Culex pipiens and Culex theileri has been identified in the sampled areas. The development of the RVF-PPR vaccine candidate is based on the NSmGN-FVR and H-PPR gene expression - where each of the genes is inserted into the thymidine kinase and the Interleukin 8 receptor analogue genes, respectively. The vector chosen is the vaccine strain Sheeppox Kenya-1. Although the double recombinant RVF-PPR has been produced, it could not be purified. The alternative was to evaluate the protection and the immunogenicity of the single recombinant capripoxvirus NSmGN-FVR, which is a product of an intermediate step of the process of the double recombinant preparation. The protection of our vaccine candidate has been performed by two mice experiments in Mus m. musculus MBT/Pas, with challenge. The number of doses, the route of administration played a key role in the protection confirmed by the presence of neutralizing anti-RVF antibodies. The study of the immunogenicity of the vaccine candidate was conducted in goats without challenge, RVF seroconversion has been shown. Lymphoproliferation studies and lymphocytes subpopulations typing have been analysed.

Análises de proveniência sedimentar são tradicionalmente utilizadas com o objetivo de reconstruir a relação entre depósitos sedimentares e suas respectivas áreas fonte, de forma a permitir a composição do contexto tectônico regional. Uma aplicação menos explorada dos métodos de análise de proveniência sedimentar é a avaliação detalhada das variações de áreas fonte ao longo da história de preenchimento de uma bacia sedimentar e das variações locais de proveniência em intervalos estratigráficos específicos. Tais estudos podem trazer importantes inferências sobre a configuração dos alto estruturais vizinhos à bacia sedimentar, assim como informações a respeito de eventos tectônicos capazes de mudar o padrão das drenagens que alimentam a bacia sedimentar. Na Bacia Camaquã (Ediacarano-Cambriano, RS) o Grupo Santa Bárbara e o Grupo Guaritas registram eventos de atividade de altos estruturais durante a sedimentação, responsáveis pela segmentação da bacia em sub-bacias. O Grupo Santa Bárbara compreende sucessões siliciclásticas distribuídas em três sub-bacias separadas pelos altos de Caçapava do Sul e da Serra das Encantadas. Na sub-bacia ocidental esse grupo apresenta depósitos de arenitos e conglomerados aluviais, depósitos siltoarenosos de ambientes fluviais distais e lacustres e depósitos conglomeráticos de leques aluviais, que compõem um ciclo retrogradacional inicial, seguido por dois ciclos progradacionais separados por uma superfície brusca. O Grupo Santa Bárbara na sub-bacia central, por sua vez, apresenta uma sucessão siltoarenosa com base conglomerática, que se estende até a porção média da sucessão sedimentar, quando dá lugar a depósitos conglomeráticos de leques aluviais que são depois sucedidos por nova sucessão siltoarenosa no topo da unidade. O Grupo Guaritas apresenta depósitos de rios entrelaçados na base e no topo da unidade, com interdigitação de sistemas deposicionais eólicos, de rios entrelaçados e de leques aluviais na porção intermediária da sucessão. Os depósitos do Grupo Santa Bárbara na sub-bacia ocidental foram investigados em detalhe por meio de levantamentos sistemáticos de dados de proveniência em escala de afloramento, em lâmina delgada e por meio de análises isotópicas em zircões detríticos. Os resultados mostram áreas fonte distintas entre os depósitos aluviais da base e do topo da unidade, sendo que em ambos a proveniência é local. Os depósitos da base têm áreas fonte a oeste e sudoeste da bacia, enquanto os depósitos do topo da unidade têm áreas fonte a leste da bacia, no alto de Caçapava da Sul, sugerindo uma mudança na configuração das áreas fonte que teria início correspondente ao primeiro nível conglomerático da sucessão aluvial intermediária da unidade. Adicionalmente os dados de proveniência indicam ausência de deslocamento entre áreas fonte e depósitos sedimentares indicando que o rejeito das falhas de borda é normal, como esperado para bacias do tipo rift. As sucessões sedimentares do Grupo Santa Bárbara na sub-bacia central foram investigadas de maneira preliminar por meio de análise de proveniência macroscópica. Os dados indicam pouca variação de áreas fonte na história da bacia, com áreas fonte predominantemente no Alto da Serra das Encantadas, que estaria então soerguido. Nos depósitos conglomeráticos superiores há uma contribuição de litoclastos atribuídos ao Alto de Caçapava do Sul. O Grupo Guaritas teve depósitos sedimentares do topo de sua sucessão estudados por meio de análise de proveniência macroscópica em depósitos de leques aluviais e em depósitos fluviais, que cobrem os anteriores em contato erosivo. Os dados apontam para proveniência estritamente local, do Alto da Serra das Encantadas nos depósitos de leques aluviais, enquanto que os depósitos fluviais contam com áreas fonte mais distantes, sugerindo que o Alto da Serra das Encantadas sofreu subsidência e foi recoberto nesse intervalo de tempo. Os dados indicam que o soerguimento do Alto de Caçapava do Sul, que se deu durante a deposição do Grupo Santa Bárbara e individualizou a sub-bacia ocidental, teria provocado uma progradação instantânea dos depósitos sedimentares, ao contrário do previsto em modelos tectônicos disponíveis, em consequência do aumento do aporte sedimentar pela erosão de sedimentos pouco litificados depositados sobre o Alto de Caçapava do Sul e de uma queda na taxa de subsidência das bacias provocado por um amplo domeamento antes da nucleação da falha de borda. Tal progradação está registrada nas sucessões aluviais intermediárias do Grupo Santa Bárbara nas sub-bacias ocidental e central. Após o estabelecimento da falha normal na borda leste do alto estrutural há uma passagem brusca para depósitos mais distais, na sub-bacia ocidental seguida de progradação de cunhas clásticas no topo da unidade, enquanto que na sub-bacia central há uma retrogradação sugerindo que o soerguimento do Alto de Caçapava do Sul tenha resultado na captura de um sistema de drenagem que alimentava toda a bacia para o graben da bacia ocidental, diminuindo assim o aporte sedimentar na sub-bacia central. O Grupo Guaritas indica, por sua vez, uma situação inversa, com mudança nos sistemas deposicionais provocada pela subsidência do Alto da Serra das Encantadas, que teria permitido a captura de sistemas de drenagem para dentro da bacia, promovendo o aumento do aporte sedimentar e a substituição dos sistemas eólicos e de leques aluviais por sistemas fluviais entrelaçados. / Sedimentary provenance is generally used aiming the reconstruction of the relations between sedimentary deposits and their source areas, in order to interpret the regional tectonic setting. An application that is less frequent in sedimentary provenance analysis is the detailed assessment of the changes in the source areas during the infilling history of a sedimentary basin and of the local variation of the provenance data in specific stratigraphic intervals. Such studies can result in important inferences concerning the configuration of adjacent structural highs, as well as information about tectonic events that are capable of changing the drainage network feeding the sedimentary basin. In the Camaquã Basin (RS) the Santa Bárbara and Guaritas groups register events of syn-sedimentary movement of structural highs, which caused the segmentation of the basin into sub-basins. The Santa Bárbara Group comprises siliciclastic successions distributed in three sub-basins separated by the Caçapava do Sul and Serra das Encantadas structural highs. The western sub-basin contains alluvial sandstones and conglomerates, siltstones and sandstones of fluvial and lacustrine environments, and alluvial fan conglomerates, disposed in a initial retrogradatinoal cycle, and two overlying progradational cycles, which are separated by a abrupt flooding surface. In the central sub-basin, the Santa Bárbara Group comprises a siltstone and sandstone succession with conglomerates at its base, followed by alluvial fan conglomeratic deposits in the middle part of the sedimentary succession, which in turn is succeeded by another succession of siltstones and sandstones at the top of the group. The Guaritas Group shows braided river deposits both at the base and the top of the unit, with interfingering of eolian, braided river and alluvial fan systems in the intermediate part of the succession. The deposits of the Santa Bárbara Group in the western sub-basin were investigated in detail through systematic studies of provenance both at the outcrop scale and in thin sections and by detrital zircon isotope analysis. The results show distinct source areas for the alluvial deposits of the base and the top of the unit, with a local sources for both of them. The lower deposits had source areas to the west and southwest of the basin, while the upper ones had source areas to the east of the basin, on the Caçapava do Sul High, suggesting a change in the configuration of the source areas, with its onset corresponding to the first conglomeratic level of the intermediate alluvial succession of the Santa Bárbara Group. The provenance data also shows that there is no significant lateral displacement deposits relative to their source areas, suggesting that the main displacement of the border faults was normal, as expected for rift basins. The sedimentary successions of the Santa Bárbara Group in the central sub-basin were preliminarily investigated through macroscopic provenance analysis. The data implies only in small changes of the source areas through the history of the basin, with source areas in the Serra das Encantadas High, which was then uplifted. In the upper conglomeratic deposits there is some contribution of lithoclasts from the Caçapava do Sul High. The sedimentary deposits of the top of the Guaritas Group were studied through macroscopic provenance analysis in alluvial fan and fluvial deposits, the latter covering the alluvial fans in erosive contact. The data points to strictly local provenance, from the Serra das Encantadas High in the alluvial fan deposits, while the fluvial deposits had also more distant source areas. This suggests that the Serra das Encantadas High subsided during this period, and was covered by the younger fluvial deposits. The collected data suggests that the Caçapava do Sul High uplift, which took place during the deposition of the Santa Bárbara Group and individualized the western sub-basin, triggered a progradation of the sedimentary deposits. This is not in accordance with the existing models, and could be explained as a result of both of an increase in the sedimentary input by erosion of unlithified sediments deposited on the Caçapava do Sul High and of the fall in the subsidence rates of the sedimentary basins due to a wide doming before the nucleation of the main border fault. Such progradation is registered in the alluvial successions of the Santa Bárbara Group in the western and central sub-basins. After the definition of the normal faulting in the eastern border of the structural high, an abrupt passage to distal facies took place in the occidental sub-basin, which was in turn was followed by progradation of clastic wedges on the top of the unit, while in the central sub-basin there is a retrogradation, suggesting that the uplift of the Caçapava do Sul High would have resulted in the capture of a main drainage system, that fed the entire basin, to the western basin graben, and so decreasing the sedimentary input to the central sub-basin. The Guaritas Group in its turn indicates a change in the depositional systems caused by the subsidence of the Serra das Encantadas High, which allowed the capture of drainage systems to the basin, thus increasing the sedimentary input and the substitution of the eolian and alluvial fan systems by braided fluvial systems.

As coquinas de bivalves do Grupo Lagoa Feia (Eoaptiano) ocorrem na área sudoeste da Bacia de Campos e constituem reservatórios de hidrocarbonetos. Foram descritos 1030 metros de testemunhos e 368 lâminas delgadas para definir os controles estratigráficos dos eventos e produtos diagenéticos observados e propor um método de predição da paragênese diagenética. Inicialmente foram definidas 34 fácies sedimentares posteriormente agrupadas em 7 associações de fácies nas quais foram reconhecidos os conjuntos de processos geneticamente relacionados, que levaram à interpretação do paleosistema deposicional. Sete produtos eodiagenéticos foram observados na seção informalmente denominada Coquina Inferior e desses, quatro alteram bastante as características permoporosas primárias das rochas, sendo eles: cimentação por calcita blocosa em mosaico, cimentação por sílica microcristalina (quartzo), cimentação por calcedônia e dissolução. Interpreta-se um forte controle do(s) tipo(s) de produto(s) diagenético(s) com a variação do nível base do lago, conforme as seguintes premissas: o cimento de sílica microcristalina ocorre preferencialmente quando o nível base está alto e as rochas sob condições lacustre freáticas, pois, devido ao grande escoamento superficial, o lago neste momento encontra-se enriquecido em Si (proveniente do intemperismo e lixiviação das seções de rochas anteriores), porém ainda diluído (com um volume de água muito amplo), favorecendo a precipitação do quartzo e não da calcedônia. A partir do momento em que o nível do lago cai relativamente, a concentração de Si aumenta e a calcedônia passa a ser o cimento principal. Neste momento, as rochas estão sob condições de ambiente de zona de mistura, pois o nível do lago estaria mais baixo, porém ainda não totalmente em condições de domínio meteórico. A seguir, com nível do lago mais baixo ainda, as rochas passam para o ambiente meteórico e ocorre a precipitação de calcita blocosa (provavelmente necessitando de um tempo de residência baixo, pois o mineral ocorre em todo o intervalo da Coquina Inferior) no meteórico freático, e dissolução no meteórico vadoso. Quando o nível do lago volta a subir, as condições favorecem novamente a precipitação de calcedônia, e, em um nível posterior, mais alto ainda, de sílica microcristalina, iniciando assim um novo ciclo de alterações diagenéticas. A correlação entre a paleobatimetria deposicional da associação de fácies sedimentar e o nível base requerido para determinado(s) tipo(s) de produto(s) diagenético(s) encontrado(s) levou à criação de uma curva de \"velocidade relativa de variação do nível base\", que pôde também ser construída sinteticamente a partir das fácies sedimentares e dos perfis de raios gama e sônico. Tendo em mãos essa curva sintética, foi possível fazer o \"caminho inverso\" e criar um modelo preditivo (ou seja, sem descrição da diagênese em lâminas delgadas) da paragênese diagenética a partir da associação de fácies sedimentar e da \"velocidade relativa de variação do nível base\" em escala de poço (1D) e também em um grid geocelular (3D). A seção Coquina Inferior dos reservatórios da Bacia de Campos apresenta elevado grau de heterogeneidade vertical, gerada pela ciclicidade estratigráfica e pela intensa modificação eodiagenética. O entendimento dos fatores controladores da diagênese levou à criação de um método preditivo da paragênese diagenética em escala de poço (1D) e também em um grid geocelular (3D) que poderá ser usado para a caracterização e gerenciamento de outros campos petrolíferos em carbonatos. / The bivalve coquina from Lagoa Feia Group (Eoaptian), occurs in southwestern part of Campos Basin and consists petroleum reservoirs. 1030 meters of core and 368 thin sections were described to define the stratigraphic controls of the diagenetic events and then create a diagenetic paragenesis predictive method. Firstly, 34 sedimentary facies were defined and then grouped in seven facies associations. These associations have the same genetically depositional process relationship and they were used to define the depositional paleosystem. Seven eodiagenetic products were observed in the informally called Lower Coquina section and four from these products cause an important primary rock permeability and porosity alteration: block calcite cementation, microcrystaline silica (quartz) cementation, chalcedony cementation and dissolution. There is a strong control of the diagentic(s) product(s) type(s) and the base level variation. Microcrystaline silica occurs when the base level is high and the conditions are under lacustrine phreatic environment. Under these conditions, the lake has a Si enrichment due to run off great rates but still diluted, because the huge volume of water. This situation favors the precipitation of quartz instead of chalcedony. When the lake level falls, Si concentration rises, and chalcedony becomes the main cement phase. At this time, the conditions are mostly under mixing zone. When the lake falls again, meteoric environment becomes predominant. At the meteoric phreatic environment blocky calcite occurs as cement and at the meteoric vadose zone environment dissolution is the main process. When the lake level raises again, the conditions favor the precipitation of chalcedony and, in the next level, (higher base level than previous) the conditions are good to microcrystaline silica precipitation. At this moment, a new diagenetic cycle is started. The correlation between depositional paleobathymetry of sedimentary facies association and the lake level required for different types of diagenetic paragenesis led to the creation of a curve called \"relative velocity of base level variation\". This curve may also be calculated synthetically from sedimentary facies, gamma ray and velocity logs. With this synthetic curve it was possible to do a \"reverse path\" procedure and generated a diagenetic paragenesis predictive method. The coquina reservoir has a high level of heterogeneity due to stratigraphic cyclicality and due to eodiagenetic transformations. The understanding of diagenetic controls led to a diagenetic predictive method creation on 1D (well) and 3D (geocell grid). This knowledge can be used for the characterization and management of others carbonates associated oil fields.