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The purpose of this study was to determine duration time, breakage and apical displacement, whilst using six different endodontic filing systems to prepare molar teeth. A total of 96 molar teeth were used in the study, divided equally, ie 16 teeth per system selected randomly, totalling 48 canals per system. A standardised access cavity was prepared for all the teeth before selection. The canals were filed according to the manufacturers&rsquo / guidelines. The result showed that PROTAPER&reg / , K3&trade / and the combination of: HERO Shaper&reg / , HERO Apical&reg / and Endoflare&reg / (Referred from hereon as HERO System for convenience) were statistically faster than PROFILE&reg / and FlexMaster&reg / , which were in turn faster than AETTM. Although breakage did occur in K3&trade / and HERO System this was not deemed statistically significant. Apical displacement occurred in the form of Type 1 in the AETTM, PROFILE&reg / and HERO System, but once again this was not statistically significant. It was concluded that more aggressive cutting features such as a positive rake<br /> angle, pyramidal shaped tip, progressive taper and absence of radial lands, if present, could have enabled K3&trade / , HERO System and PROTAPER&reg / to have faster times, and in addition these features did not compromise these systems with regard to apical foramina transportation and breakage.

In an experiment investigating the influence of M. graminicola on rice yield, M. graminicola caused as significant yield reduction in Azucena but not in Bala indicating that this variety is tolerant. The influence of abiotic (nitrogen and water) and biotic (vesicular arbuscular mycorrhiza - VAM) factors on the nematode/rice interaction were also studied. Nitrogen stress affected Azucena plants but not Bala. Drought did not influence susceptibility of either variety but caused a significant reduction in root weight which was greater when nematodes were present in both rice varieties.

Diagnosis and treatment of teeth with longitudinal fractures is challenging. Cracks are usually not visible radiographically; they require a thorough evaluation to aid in diagnosis. Patients may be asymptomatic, demanding the dentist rely on clinical findings to make a diagnosis. Early diagnosis of the presence and extent of a crack is essential for the successful management of a cracked tooth. There is limited information in the literature regarding the prevalence or predictive factors of cracks extending into the pulp chamber of teeth. The purpose of this study was to determine the prevalence of intrapulpal cracks in maxillary molars and to identify factors that may aid in diagnosing the existence of a crack. All maxillary molar teeth requiring non- surgical root canal therapy or retreatment at the Virginia Commonwealth University graduate endodontic clinic from June 2016 through December 2016 were included in the study after obtaining patient consent. Teeth were examined visually, transilluminated, stained, and examined microscopically for the presence of an intrapulpal crack. Demographic information, subjective data associated with the chief complaint, objective results of diagnostic testing (percussion, palpation, bite stick test, transillumination, probing depths, existing restorations, and diagnosis) were analyzed using chi-square and logistic regression (p<0.05) to identify associations of these findings with the existence of a crack. A total of 18% (15/82 teeth) of maxillary molars that were evaluated and had endodontic treatment initiated were cracked. There was a significant association between cracked teeth and pain on biting (P<.0001) and with probing depths greater than 4 millimeters (mm) (P < 0.003). Those positive on a tooth slooth test were more likely to have an intrapulpal crack (P<.001) and teeth with a positive transillumination test were also found to be associated with the presence of a crack(P < .001).

The circuit of recurring inhibition between motor neurons and Renshaw cells in the spinal cord has been known for around 70 years, though no determined function has been outlined as of yet. Renshaw cells are thought to be part of the central pattern generator in the spinal cord establishing them as an important part of the animal’s locomotive properties. In this study we aimed to investigate the role of Renshaw cells in locomotion with the help of optogenetics and electrophysiology. Halorhodopsin was inserted into the genome of mice and driven to expression with Cre recombinase in Renshaw cells. The spinal cord of P3 mice was extracted and by inducing fictive locomotion with appropriate neurotransmitters we could inhibit the Renshaw cells in action with a green laser, opening the halorhodopsin channels for Cl- ions. In previous experiments where the ability of Renshaw cells to release inhibitory neurotransmitters was inactivated, no effect was observed in either behavioral experiments or electrophysiological experiments. In a system where the effect of Renshaw cells was knocked out acutely with optogenetics there was no discernible change in fictive locomotion cycle length, frequency or amplitude. Nor was there an effect on alternation. The access of light to the Renshaw cells area might have been limited during the experiment considering the angle of light delivery and strength of the laser. Furthermore, the maturity of Renshaw cells at P3, the exclusive ability of the marker used to target Renshaw cells and the observed nature of neonatal inhibitory neurons acting as excitatory neurons could all be called into question about whether they contributed to these results or not.

Bimetric theory is an extension to general relativity that introduces a secondary symmetric rank-two tensor field. This secondary spin-2 field is also dynamical, and to avoid the Boulware-Deser ghost issue, the interaction between the two fields is obtained through a potential that involes the matrix square-root of the tensors. This square-root “quantity” is a linear transformation, herein referred to as the square-root isometry. In this work we explore the conditions for the existence of the square-root isometry and its group properties. Morever we study the conditions for the simultaneous 3+1 decomposition of two fields, and then, in terms of null-cones, give the (local) causal relations between fields coupled by the square-root isometry. Finally, we show the algebraic equivalency of bimetric theory and its vielbein formulation up to a one-to-one map relating the respective parameter spaces over the real numbers. / Den bimetriska teorin är en utökning av den allmänna relativitetsteorin som introducerar ett sekundärt symmetriskt tensorfält av rang-två. Det här sekundära spin-2 fältet är också dynamiskt, och för att undvika Boulware-Deser spöke, erhålls vaxelverkan mellan de två fältena genom en potential som er baserad på kvadratrotsmatris av två tensorfält. Den “kvadratroten” är en linjär avbildning som kallas kvadratrotsisometri. I detta arbete utforskas förutsättningar för existensen av kvadratrotsisometrin och ges dess egenskaper i termer av gruppteori. Därutöver utforskas förutsättningarna för den samtidiga 3+1 dekompositionen av två tensorfält och sedan, i termer av ljuskoner, ges de (lokala) kausala relationerna för tensorfält kopplade genom kvadratrotsisometrin. Slutligen bevisas den algebraiska ekvivalensen mellan den bimetriska teorin och dess vielbein formulering upp till en bijektiv relation mellan respektive parameterutrymmen över de reella talen. / <p>Summarizes the results from the project done between March 2014 and November 2014.</p>

The purpose of the present study was sixfold: 1. To study the effects of x-irradiation on spinal cord activity. 2. To study the effects of CNS drugs on spinal cord function as reflected by changes in the ventral root potentials. 3. To ascertain whether one can alter the observed spinal response to ionizing radiation by applying CNS drugs prior to, during, and following x-irradiation of a given spinal cord segment. 4. To shed some light on the role of higher brain centers on spinal reflexes. 5. To shed some light on the loci of radiation insult to the spinal cord. 6. To establish evidence for a possible drug-irradiation interaction in mammals.

The purpose of this study was to test the number of rotations to fracture of the M-Wire GT® Series X(TM) rotary files compared to the original ProFile® GT® rotary files in a simulated curved canal. Eighty GT® Series X(TM) files of 25mm length were divided into eight groups of ten, one for each of the new GT® Series X(TM) files. Eighty original ProFile® GT® files of 25mm length were divided into eight groups of the same tip and taper sizes consistent with the GT® Series X(TM) file groups. Files were rotated at 300 rpm. While the angle may have slightly changed due to the flexure property of the file, the angle was the same for each file with the same tip and taper. The time to fracture was recorded and rotations to fracture were calculated. The data collected was analyzed using a two-way ANOVA, followed by specific post-hoc contrasts comparing the two brands for each tip and taper combination. The results show the M-Wire GT® Series X(TM) files were significantly more resistant to fracture by cyclic fatigue than the ProFile® GT® rotary instruments for the following tip and taper sizes: 20/.04, 30/.04, 30/.06, 30/.08, and 40/.08. The following tip and taper sizes: 20/.06, 40/.04, and 40/.06 were not statistically significant.

The purpose of this study was to examine the number of rotations to failure of two different rotary file systems, EndoSquence Brassler USA (Savannah, GA) and GT(TM) series X(TM). Files sizes 20,30,40 with 0.04, 0.06 tapers of GT series X and Endo Sequence files size and taper used were 20, 30, 40 with 0.04 and 0.06 taper. Like tip and tapers were compared between systems. All files tested were 25mm in length. Files were allocated into 12 groups of 10 files each, and mounted to a universal testing machine. Each file was rotated at 300 rpms until fractured occurred. The number of rotations to fracture were calculated. A two-way ANOVA indicated that each of the 12 groups were significantly different (p < .0001). The Brand Tip/Taper interaction indicated that the differences between the brands varied by Tip/Taper combination (p < .0001). The tip/taper combination 20/.04, the GT series X file rotated 1.4 times longer than the EndoSequence (p = 0.0027). The tip/taper combination 20/.06, the GT series X file rotated 1.61 times longer than the EndoSequence (p = <.0001). The tip/taper combination 30/.04, the GT series X file rotated 3.67 times longer, than the EndoSequence (p = <.0001). For the tip/taper combination 30/.06, the GT series X file rotated 2.63 times longer than the EndoSequence (p = <.0001). For the tip/taper combination 40/.06, the GT series X file rotated 4.05 times longer than the EndoSequence (p = <.0001). In comparing all these tip and taper combinations GT series X was significantly higher rotations to failure. Comparing tip/taper combination 40/.04, the GT series X file rotated 1.22 times longer, however, this was not significantly different than the Sequence (p = 0.0707). The results suggested that the number of rotations to failure for GT series X files were greater than the EndoSequence file of the same tip and taper combination.

The purpose of this study was to compare the resistance to fracture by the twisting of two nickel titanium (NiTi) rotary file systems. The Profile® GT® (GT) and the GT® Series X(TM) (GTX) files were tested to analyze the maximum torsional strength and the maximum angular deflection at the time of separation of the files. For each system, ten new files were tested at each of the following eight taper/size designations for a total of 160 files: 20/0.04, 20/0.06, 30/0.04, 30/0.06, 30/0.08, 40/0.04, 40/0.06, and 40/0.08. The American National Standards Institute / American Dental Association Specification No. 28 was implemented to evaluate torsional limits for these intruments. Files were mounted in a Maillefer Torsiometre machine, which records maximum torsional strength and angular deflection at separation for each file. A two-way ANOVA revealed significant differences after comparing the size and type of file. The GT files required significantly more torque to separate than the GTX files in all groups tested except the GTX file size 20/0.06, which required significantly more maximum torque than the GT file, with no significant difference between the GT and GTX files for size 30/0.04. The GT files exhibited values for angular deflection at separation that were significantly higher than those for the GTX files at sizes 30/0.04 and 40/0.08 and the GTX files exhibited higher values at size 30/0.08 with no significant difference between the brands at the remaining five file sizes. In summary, the GT files required significantly more torque to fracture and exhibited values for angular deflection at separation that were significantly higher than the GTX files for in 6 of 8 and 2 of 8 file sizes, respectively.