Die Entwicklung eines künstlerischen Gestaltungsprogramms für das komplette Schloss Albrechtsburg steht im Zentrum des Beitrages. Dabei reicht der Bogen von der Beauftragung des Kunsthistorikers Wilhelm Rossmann 1874 über die Ausarbeitung eines Entwurfs zur Ausschmückung, dessen Diskussion in der Fachwelt, den Blick auf Vorbilder und die Auswahl der Künstler bis hin zu Fragen der Ausführung und Technik der Wandgemälde.

Monotopic proteins represent a specialized group of membrane proteins in that they are engaged in biochemical events taking place at the membrane interface. In particular, the monotopic lipid-synthesizing enzymes are able to synthesize amphiphilic lipid products by catalyzing two biochemically distinct molecules (substrates) at the membrane interface. Thus, from an evolutionary point of view, anchoring into the membrane interface enables monotopic enzymes to confer sensitivity to a changing environment by regulating their activities in the lipid biosynthetic pathways in order to maintain a certain membrane homeostasis. We are focused on a plant lipid-synthesizing enzyme DGD2 involved in phosphate shortage stress, and analyzed the potentially important lipid anchoring segments of it, by a set of biochemical and biophysical approaches. A mechanism was proposed to explain how DGD2 adjusts its activity to maintain a proper membrane. In addition, a multivariate-based bioinformatics approach was used to predict the lipid-binding segments for GT-B fold monotopic enzymes. In contrast, a soluble protein Myr1 from yeast, implicated in vesicular traffic, was also proposed to be a membrane stress sensor as it is able to exert different binding properties to stressed membranes, which is probably due to the presence of strongly plus-charged clusters in the protein. Moreover, a bacterial monotopic enzyme MGS was found to be able to induce massive amounts of intracellular vesicles in Escherichia coli cells. The mechanisms involve several steps: binding, bilayer lateral expansion, stimulation of lipid synthesis, and membrane bending. Proteolytic and mutant studies indicate that plus-charged residues and the scaffold-like structure of MGS are crucial for the vesiculation process. Hence, a number of features are involved governing the behaviour of monotopic membrane proteins at the lipid bilayer interface. / At the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 3: Manuscript. Paper 5: Manuscript.

Today, globalization, new technologies and modernization bring a lot of negative influences on our environment and society we live in, compared to the positive effects they create. And that is the reason why so many companies are embarking on socially beneficial goals, rather than profit. The aim of the diploma thesis is to explore and evaluate a concept of corporate social responsibility at Rossmann. In the theoretical part of the thesis I familiarize the reader with corporate social responsibility, dealing with the main characteristics of the concept and actual situation in the Czech republic. The second chapter deals with the characteristics of Rossmann and its activities in the CSR field. The practical part consists of two parts. The first one focuses on internal and external analysis of the company`s environment with regards to CSR. The second practical part is concerned with the empirical research, that was realized by the questionnaire investigation. Following the gained knowledge I will answer the fundamental question: How is the corporate social responsibility part of the company strategy? I will propose measures that will lead to increasing awareness of CSR and the advantages that using CSR brings to the company more effectively.

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