To enable a new level of connectivity among machines as well as between people and machines, future wireless applications will demand higher requirements on data rates, response time, and reliability from the communication system. This will lead to a different system design, comprising a wide range of deployment scenarios. One important aspect is the evolution of physical layer (PHY), specifically the waveform modulation. The novel generalized frequency division multiplexing (GFDM) technique is a prominent proposal for a flexible block filtered multicarrier modulation. This thesis introduces an advanced GFDM concept that enables the emulation of other prominent waveform candidates in scenarios where they perform best. Hence, a unique modulation framework is presented that is capable of addressing a wide range of scenarios and to upgrade the PHY for 5G networks. In particular, for a subset of system parameters of the modulation framework, the problem of symbol time offset (STO) and carrier frequency offset (CFO) estimation is investigated and synchronization approaches, which can operate in burst and continuous transmissions, are designed. The first part of this work presents the modulation principles of prominent 5G candidate waveforms and then focuses on the GFDM basic and advanced attributes. The GFDM concept is extended towards the use of OQAM, introducing the novel frequency-shift OQAM-GFDM, and a new low complexity model based on signal processing carried out in the time domain. A new prototype filter proposal highlights the benefits obtained in terms of a reduced out-of-band (OOB) radiation and more attractive hardware implementation cost. With proper parameterization of the advanced GFDM, the achieved gains are applicable to other filtered OFDM waveforms. In the second part, a search approach for estimating STO and CFO in GFDM is evaluated. A self-interference metric is proposed to quantify the effective SNR penalty caused by the residual time and frequency misalignment or intrinsic inter-symbol interference (ISI) and inter-carrier interference (ICI) for arbitrary pulse shape design in GFDM. In particular, the ICI can be used as a non-data aided approach for frequency estimation. Then, GFDM training sequences, defined either as an isolated preamble or embedded as a midamble or pseudo-circular pre/post-amble, are designed. Simulations show better OOB emission and good estimation results, either comparable or superior, to state-of-the-art OFDM system in wireless channels.