Existe una alteración de la función de las Glándulas salivales en la fase temprana de la infección por el VIH, la cual altera la calidad y la cantidad de la saliva durante el transcurso de la enfermedad. Objetivo: Determinar el Perfil salival de los pacientes con Infección por VIH y Con y Sin Tratamiento Antirretroviral de Gran Actividad (TARGA) y su asociación con su Grado de Inmunosupresión. Material y Métodos: Se evaluaron; el Perfil salival por medio de la evaluación de los Síntomas de Hipofunción salival (Xerostomía, Disgeusia, Disfagia y Susceptibilidad de desarrollar ulceras orales) a través de una encuesta, la Tasa de Flujo salival no estimulado a través del Método Gravimétrico, el pH salival por medio de la Cinta universal de pH y la Viscosidad salival a través del Método de Ostwald; así como el Grado de Inmunosupresión por medio del Recuento de Linfocitos CD4/µl; de 126 pacientes con infección por VIH, 65 Con TARGA y 61 Sin TARGA que asistieron al Servicio de Enfermedades infecciosas y tropicales (SEIT) del Hospital Nacional Dos de Mayo - Perú, atendidos entre los meses de Diciembre del 2008 y Enero del 2009. Resultados: Los pacientes Sin TARGA presentaban un porcentaje significativamente mayor de algunos Síntomas de hipofunción salival: Xerostomía (P igual .000), Disgeusia (P igual 0.051), Disfagia (P igual .001) y Susceptibilidad de desarrollar ulceras orales (P igual .000), así como valores significativamente más altos de Viscosidad salival (P igual .000); sin embargo, presentaban también valores significativamente más bajos de Tasa de flujo salival no estimulado (P igual .000) y de pH salival (P igual .000), respecto a los pacientes Con TARGA. Por otro lado, los pacientes con un mayor Grado de Inmunosupresión presentaban porcentajes significativamente más altos de Síntomas de hipofunción salival (P igual .000) y Viscosidad salival (P igual .000), sin embargo, presentaban también valores significativamente más bajos de Tasa de Flujo salival no estimulado (P igual .000) y de pH salival (P igual .000), respecto a los pacientes con un menor Grado de Inmunosupresión. Conclusión: Existe una alteración del Perfil salival de los pacientes con Infección por VIH, la cual es significativamente mayor en los pacientes Sin TARGA y en aquellos que tienen un mayor Grado de Inmunosupresión. / In the early stage of HIV infection there is disorder of the function of salivary glands, this affects the quality and quantity of spit during the course of the disease. Objective: To determine the Salivary Profile in patients with HIV infection with and within Highly Active Anti-Retroviral Therapy (HAART) and its association with its Immunosuppression Degree. Material and Methods: It was evaluated; the Salivary Profile by mean the evaluation of Symptoms of Salivary Hypofunction (Xerostomia, Dysphagia, Dysgeusia and Susceptibility to develop oral ulcers) through a survey, the Unstimulated Salivary Flow Rate by mean Gravimetric Method, the Salivary ph by universal pH Tape, Salivary viscosity through the Ostwald Method, and the Immunosuppression Degree through the CD4/µl lymphocytes re-count; in 126 patients with HIV infection, 65 with HAART y 61 without HAART that attended to the Service of Infectious and Tropical Diseases of the Hospital Nacional Dos de Mayo – Perú, during the months of December 2008 and January 2009. Results: The Non - HAART patients presented a significantly higher percent of some Symptoms of Salivary Hypofunction: Xerostomia (P same .000), Dysgeusia (P same 0.051), Dysphagia (P same .001) and Susceptibility to develop oral ulcers (P same .000), as well as significantly higher values of Salivary viscosity (P same .000); nevertheless, they showed significantly lower results of the Unstimulated Salivary Flow Rate (P same .000) and Salivary ph (P same .000) respect to HAART patients. On the other hand, the patients with a higher Degree of Immunosuppression presented a significantly higher percent of Symptoms of Salivary Hypofunction (P same .000) and Salivary Viscosity (P same .000), however, they also presented significantly lower values of the Unstimulated Salivary Flow Rate (P same .000) and Salivary ph (P same .000) respect to lower Immunosuppression Degree patients. Conclusions: There is an alteration of the salivary profile in patient with HIV infection, which is significantly higher in Non - HAART patients and those who have a higher Immunosuppression Degree.

Thesis--New York University. / Photocopy of typescript. Ann Arbor, Mich. : University Microfilms International, 1977. -- 21 cm. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 73-80).

Thesis (Ph. D.)--Lehigh University, 2003. / Includes vita. Includes bibliographical references (leaves 150-165).

INTRODUCTION Type 1 (insulin dependent) diabetes mellitus (T1DM) is the most common of the endocrine-metabolic syndrome of childhood and adolescence, characterized by hyperglycemia as a cardinal biochemical feature, with important consequences for physical and emotional development (Alemzadeh R. and Wyatt D.T., 2004). The incidence of childhood T1DM is rising in many countries of the world (Rewers M. et al., 1988, Karvonen M. et al., 1993, Soltèsz G.et al., 2003). In Lithuania, a significant increase over the last 20 years was found in the 10 – 14 year age group (Urbonaitė B. et al., 2002, Pundziūtė-Lyckå A. et al., 2004). Patients with T1DM are characterized by decreased salivary flow and lower buffer effect (P.A. Moore et al., 2001, A.D. Mata et al., 2004, G. Aren et al., 2003), salivary gland pathology (I.D. Mandel, 1980, S.B. Russotto, 1981), increased glucose concentration in the saliva (R. Harrisson and W.H. Bowen 1987, M.A. Belazi et al., 1998), periodontal diseases (L. Sandholm et al. 1989, V. de Pommereau et al. 1992), and oral yeasts (G. A. Bartholomew et al, 1987; P.J. Lamey et al., 1988). However, scientific data about the relationship between T1DM and oral health are contradictory. It has been suggested that hyperglycemia is associated with decreased salivary secretion and high salivary glucose levels, particularly in cases of severe insulin deficiency. However, no clear evidence has been found for a possible association between dental caries and diabetes... [to full text]

Messenger ribonucleic acid (mRNA) turns out to be an increasingly important molecule in forensic analysis of biological samples. Because of the specific role of mRNA in all living cells to transfer genetic information from DNA to proteins, mRNA is able to provide cell-specific information and regulate control of gene expression. mRNA analysis performed on an extracted mRNA sample isolated from a biological stain of a crime scene can be used to identify the nature of the tissue(s) comprising the stain. In this research, the effects of a couple of mRNA storage conditions such as cold temperature and ultraviolet light exposure on mRNA integrity from human saliva have been evaluated. Human saliva samples have been sampled and exposed to UV light and freezing temperature (-20°C) for varying lengths of time. Extracted mRNA from each sample has been quantified spectrophotometrically and subjected to real time RT-PCR to evaluate stability and integrity of one of the saliva marker transcripts, KRT13 mRNA, of treated samples compared to untreated samples. The results of this study indicated that UV light and freezing temperature don’t have a significant effect on the integrity of KRT13 mRNA. There is also no apparent correlation between Ct values of treated samples and treating intervals. This research holds important implications for the use of mRNA for applications in forensic science, an area which has not been researched extensively. / Department of Biology

For pain research, the orofacial region is unique in a number of ways. The region has complex local anatomy, including substantial sensory innervation from neural pathways, and muscles of facial expression that convey important information concerning pain intensity and associated psychological traits. Although chronic orofacial pain conditions appear prevalent, useful documentation on pain intensity ratings using well established instruments is sparse. In particular, two conditions, atypical facial pain and atypical odontalgia, are poorly understood in aetiology so that definitive treatment modalities are severely limited. The region's local biofluid, saliva, has been used to diagnose various local and systemic disease states, and to quantitate drug concentrations. However, recent studies indicate that saliva also contains some of the same peptides, e.g. bradykinin, that are involved in pain mechanisms. It may be that pharmacological-pharmacokinetic studies of these peptides could shed more information on thesignificance of their presence in saliva. This thesis consists of four major sections. Section 1 comprises of three clinical studies investigating orofacial pain. Section 2 deals with clinical laboratory studies of saliva. Section 3 is concerned with the development of chromatographic methods to assay bradykinin and its pharmacokinetics in saliva. Section 4 uses chromatography for the identification of novel salivary peptides. This thesis, then, presents clinical studies of orofacial pain and pharmacological investigations of saliva as the local biofluid.

Diss. (sammanfattning) Linköping : Univ., 2002. / Härtill 6 uppsatser.

Diss. (sammanfattning) Stockholm : Karol. inst., 2005. / Härtill 4 uppsatser.

Thesis (M.Sc. (Maxillofacial Prosthetics))--Mahidol University, 2008. / LICL has E-Thesis 0039 ; please contact computer services. LIRV has E-Thesis 0039 ; please contact circulation services.

Thesis (doctoral)--Göteborgs Universitet, 1982. / Extra t.p. with thesis statement inserted. Includes the author's published papers. Includes bibliographical references.