MSc (Med), Child Health Neurodevelopment, University of the Witwatersrand, Faculty of Health Sciences / Background: Computed tomography (CT) was introduced 40 years ago and it remains an essential part of medical practice. The indications for CT brain scans vary in different centres depending on the availability of scanners and financial resources. There is no data on the indications and results of CT brain scans in children at Chris Hani Baragwanath (CHB) Hospital. Aims: The indications for CT brain scans were quantitated and the overall results of the scans were assessed. The rate of radiological abnormalities by referral diagnosis was evaluated. Methodology: 361 Children undergoing CT brain scans were identified in a four month period from 22/01/2004 to 21/05/2004, and their records were prospectively reviewed. Results: The ages ranged from 2 days to 14 years. There were 213 males and 148 females with a male: female ratio of 1.4:1. Seizures was the commonest indication for scans (25.8%) in this study. The six common indications (partial and generalized seizures, trauma, central nervous system [CNS] infections, macrocephaly and psychomotor retardation) accounted for 67.6% of the scans. There were 233 (63.5%) abnormal scans. Cerebral atrophy was the commonest finding, present in 58 (16.1%) scans. Discussion: A high rate of positive scans was detected in this study, with intracranial infections featuring prominently (9.7%). This high yield of positive scans in the study population suggests the need for more scanner facilities at CHB hospital. DPDoFcuments Complete Click Here & Upgrade Expanded Features Unlimited Pages

Yes / Age at death estimation of human skeletal remains is one of the key issues in constructing a biological profile both in forensic and archaeological contexts. The traditional adult osteological methods evaluate macroscopically the morphological changes that occur with increasing age of specific skeletal indicators, such as the cranial sutures, the pubic bone, the auricular surface of the ilium and the sternal end of the ribs. Technologies such as CT and laser scanning are becoming more widely used in anthropology, and several new methods have been developed. This review focuses on how the osteological age-related changes have been evaluated in digital data. Firstly, the 3D virtual copies of the bones have been used to mimic the appearance of the dry bones and the application of the traditional methods. Secondly, the information directly extrapolated from CT scan has been used to qualitatively or quantitatively assess the changes of the trabecular bones, the thickness of the cortical bones, and to perform morphometric analyses. Lastly, the most innovative approach has been the mathematical quantification of the changes of the pelvic joints, calculating the complexity of the surface. The importance of new updated reference datasets, created thanks to the use of CT scanning in forensic settings, is also discussed. / CV was supported from the Danish Council for Independent Research (DFF – 4005-00102B – FTP)

No description available.

Magister Chirurgiae Dentium - MChD / Measurements and a variety of analyses of dental casts are essential for precise diagnosis of an orthodontic case. Study models have long been an essential part of orthodontic diagnosis and treatment planning. Currently virtual computerized models are available to clinicians, supplemented by dedicated software for performing needed measurements (Zilberman et al, 2003). Digital impression methods are now available and intraoral digital scanning techniques make it possible to generate study models directly from the scanning of the dentition. The aim of this study was to compare measurements taken after scanning the dental impressions to the measurements obtained from using direct intraoral scanning of the dentition. Alginate impressions of the maxillary and mandibular dentitions were taken on 20 patients and these impressions were scanned using a 3 Shape R 700 TM scanner. Direct intraoral scans of both dentitions were then performed for the same patient. Ortho analyzer TM software was used to measure the mesiodistal widths of individual teeth, and the intercanine and intermolar on digital models of the scanned impressions and digital models obtained from direct intraoral scans of the maxillary and the mandibular dentitions. The results indicated that there were no statistically significant differences between mesiodistal widths, and intercanine and intermolar distances between the two techniques (p > 0.05). Because of the high level of accuracy of the virtual measurements compared to those of the scanned impressions, it can be concluded that direct intraoral scanning of the dentition can be used with confidence in the clinical situation to measure tooth sizes and inter-arch distances for orthodontic purposes. Orthodontists commonly use models for various areas in the practice, clinical research and medico-legal documentation (Marcel, 2001)

No description available.

This report describes the results of computerized ultrasonic C-scanning of solid steel bridge pins using a raytrace model. The raytrace model was developed to facilitate interpretation of data obtained from an ultrasonic C-scanning system for the Virginia Transportation Research Council (VTRC). The report discusses the reasons behind the development of the raytrace model, as well as specifications of the model, the input conditions, and the data output and visualization. The model uses as input, various "boundary" conditions of the solid steel pin with reduced diameter pin ends, as well as size and location information of a flaw or a wear groove placed within the main pin body. The model considers sound beams to be composed of rays and calculates ray reflections/conversions. This is done until the ray returns to a receiver location or is lost due to exceeding the time-of-flight. Once the model has returned with the received ray data, it uses the receiver conditions provided (transducer used, size of scanning grid, grid resolution, etc.), and calculates a 2-Dimensional C-scan image for each particular depth/time selected. Using PV-Wave visualization software, it is possible to plot the values for each depth to view a color graph. This graphical plot can then be analyzed/compared with the field C-scans to determine the closest match of a flaw or a wear groove inside the bridge pin. This helps in deciding if the condition of the pin is acceptable. / Master of Science

Thesis (M.A.)--Boston University / The standardized uptake value (SUV) is increasingly being used for diagnosis, staging, and monitoring disease in clinical oncology. Comparing tumor SUV to background SUV is an attractive way to minimize variability and ensure the quality of scans across different institutions. The liver has been identified as a potential source for background normalization, however no studies have compared the liver to other background sites for a variety of cancers. The purpose of this study was to evaluate the use of liver uptake for the standardization of FDG PET/CT imaging. Scans from 145 patients were prospectively reviewed under the supervision of a radiologist with board certification in nuclear medicine (R.M.S. , 3 years of experience). Liver SUV values were correlated to mediastinum SUV values in lung and breast cancer patients, and internal jugular vein (IJV) SUV values in head and neck cancer patients. The independent t-test was used to determine if there was a statistically significant affect of the amount of incubation time or use of intravenous contrast on the SUV. For the lung and breast cancer patients, a strong correlation was observed between the mediastinum SUVmean and liver SUVmean (r = 0.89), whereas for the head and neck cancer patients, a weaker correlation was observed between the IJV SUVmean and the liver SUVmean (r = 0.69). Neither the amount of incubation time nor the use of IV contrast demonstrated a significant affect on the SUV. We conclude that liver SUVmean may be used to standardize FOG PET/CT studies in cancers of the lung, breast and head and neck. However, additional studies in other cancers as well as the affects of age, gender, benign disease and use of chemotherapy are still desired before widespread adoption of this standard.

Cranial vault thickness (CVT) has been reported at many different osteometric landmarks and features on the vault. Historically, only a few landmarks are used, often bregma, lambda, vertex, and right and left euryon, and frequently comparisons are based only on “thick” versus “thin” to describe the vault overall. What is inherent in this strategy is the use of a few locations to characterize the entire vault. The problem remains that there is little information concerning CVT variation throughout an individual's vault, and the causes of variation within recent Homo sapiens important to investigating thickness variation between species in Homo. This work describes thickness variation over the entire superior vault and compares the sexes, age groups and populations in recent H. sapiens. A proportional grid is applied to the superior vault to measure thickness at 219 sampling points in a geographically diverse sample of recent H. sapiens. Thickness values are analyzed in their two-dimensional spatial relationships to determine patterns of vault thickness. Males were identified to be thicker than females at more lateral locations and along the midsagittal plane, although this finding is not statistically significant. Individuals over the age of 45 years are found to be statistically significantly thicker than individuals younger than 31 years at more lateral locations of the vault. Aboriginal Australians are statistically significantly thicker at more lateral locations of the vault than any other populations, whereas Northern Canada/Greenland individuals were thinner than other populations at these locations. The trend of thicker vaults in the older age group and the Australians is identified across the vault, although is not statistically significant at more locations. Several thickness patterns are identified. The boss thickening pattern is the most common pattern, followed by a midsagittal pattern, a posterior pattern, and an anterior pattern. Some specimens do not demonstrate thickness variation and are coded as undifferentiated. Each pattern is observed alone and in combination with others, signifying that pattern causes are not mutually exclusive. Boss thickening is interpreted as the result of passive bone thickening during normal bone and brain growth during fetal and adolescent development. The midsagittal thickness pattern coincides with inferred strain along the sagittal suture from nuchal muscle engagement during mastication. Previous researchers have proposed adaptive explanations for thickness variation, such as protection from interpersonal violence; the patterns of cranial vault thickness reported here point to normal growth and development of the brain as a driving force, a relationship that could drive thickness variation in other Homo species. Comparing thickness at bregma, and the frontal and parietal eminences for recent H. sapiens and H. erectus, there is no statistical difference between African and Asian H. erectus, and between the on average thicker H. sapiens populations and H. erectus, based on published data. Future work will investigate the presence or absence of thickness patterns in these fossil species.

One of the serious public health problems is the Traumatic Brain Injury, also known as silent epidemic, affecting millions every year. Management of these patients essentially involves neuroimaging and noncontrast CT scans are the first choice amongst doctors. Significant anatomical changes identified on the neuroimages and volumetric assessment of haemorrhages and haematomas are of critical importance for assessing the patients’ condition for targeted therapeutic and/or surgical interventions. Manual demarcation and annotation by experts is still considered gold standard, however, the interpretation of neuroimages is fraught with inter-observer variability and is considered ’Achilles heel’ amongst radiologists. Errors and variability can be attributed to factors such as poor perception, inaccurate deduction, incomplete knowledge or the quality of the image and only a third of doctors confidently report the findings. The applicability of computer aided dianosis in segmenting the apposite regions and giving ’second opinion’ has been positively appraised to assist the radiologists, however, results of the approaches vary due to parameters of algorithms and manual intervention required from doctors and this presents a gap for automated segmentation and estimation of measurements of noncontrast brain CT scans. The Pattern Driven, Content Aware Active Contours (PDCAAC) Framework developed in this thesis provides robust and efficient segmentation of significant anatomical landmarks, estimations of their sizes and correlation to CT rating to assist the radiologists in establishing the diagnosis and prognosis more confidently. The integration of clinical profile of the patient into image segmentation algorithms has significantly improved their performance by highlighting characteristics of the region of interest. The modified active contour method in the PDCAAC framework achieves Jaccard Similarity Index (JI) of 0.87, which is a significant improvement over the existing methods of active contours achieving JI of 0.807 with Simple Linear Iterative Clustering and Distance Regularized Level Set Evolution. The Intraclass Correlation Coefficient of intracranial measurements is >0.97 compared with radiologists. Automatic seeding of the initial seed curve within the region of interest is incorporated into the method which is a novel approach and alleviates limitation of existing methods. The proposed PDCAAC framework can be construed as a contribution towards research to formulate correlations between image features and clinical variables encompassing normal development, ageing, pathological and traumatic cases propitious to improve management of such patients. Establishing prognosis usually entails survival but the focus can also be extended to functional outcomes, residual disability and quality of life issues.

京都大学 / 0048 / 新制・課程博士 / 博士(医学) / 甲第18853号 / 医博第3964号 / 新制||医||1007(附属図書館) / 31804 / 京都大学大学院医学研究科医学専攻 / (主査)教授 山田 泰広, 教授 武田 俊一, 教授 野田 亮 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM