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Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Lucie Hlinková Supervisor: Prof. MUDr. Radomír Hrdina, CSc. Title of diploma thesis: Treatment of schizophrenia Schizophrenia is a serious mental disease, mostly chronic. It affects about 1 % of population, first episode of the disease occurs mostly between the age of 15 and 35. It manifests itself with disorders of perception, behavior and thinking. The specific symptoms include hallucinations, delusions, disorganized speech and behavior, catatonia, disorders of attention and volition and social withdrawal. Etiopathogenesis of schizophrenia is likely affected by both genetic and environmental factors, the true cause of the disease has not been discovered yet. The goal of the treatment is to improve the patient's quality of life and prevent the occurrence of relapses. Drugs acting on the dopaminergic system are effective in the treatment of schizophrenia, where as antagonists bind to the dopamine receptors. These medicines are called antipsychotics, they are divided into two generations. The first generation is characterized by high affinity mainly for dopamine receptors, the second one in addition by binding to serotonin receptors. Each class of antipsychotics is characterized by the...

Proefschrift Universiteit van Amsterdam. / Met lit. opg. - Met samenvatting in het Nederlands.

Based on thesis, New School for Social Research. / Bibliography: p. 178-181.

Based on thesis, New School for Social Research. / Bibliography: p. 178-181.

In this study I try to survey experiences of psychotherapists who work with people that are diagnosed with schizophrenia disorder. The goal of this study is to find out what therapeutic factors contribute to effectiveness of such psychotherapy. The study is a detailed description of work experience of four clinical psychologists - therapists. The therapists were chosen in a way to represent variety of psychotherapeutic schools. Data were collected with the use of semistructured interview and then analyzed with the use of Grounded Theory Method. The study shows particular psychotherapeutic factors that are used by individual psychotherapists and how are these factors combined so such combination contributes to the effectiveness of psychotherapy. Powered by TCPDF (www.tcpdf.org)

Proefschrift Universiteit van Amsterdam. / Met lit. opg. - Met samenvatting in het Nederlands.

Tereza Petrásková Toušková - Cognitive Disorganisation and Insight in Schizophrenia 1 SUMMARY Conscious awareness is related to brain activities represented as unita- ry, integrated and changeable processes reflecting binding of diverse modalities of basic neural informational processes and their subjective components. According to recent research disturbances of self- awareness and conscious experience have a critical role in pathophysi- ology of schizophrenia, which in early stages of the disease mainly in- clude overactivation of the HPA axis. Together these studies suggest that the processes of disrupted awareness and conscious disintegration in schizophrenia likely might be related and represented by similar dis- ruptions on the brain level, which in principle could be explained by various levels of disturbed connectivity and information disintegration that may negatively affect usual patterns of synchronous activity consti- tuting adaptive integrative functions of consciousness. In this context, a purpose of the theoretical part of the disertation is to describe basic neu- robiological mechanisms underlying integrative processes in the brain with its complementarily related mental activities including self- awareness and insight reflecting interrelated processes between mind and brain that implicate...

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