Individuals diagnosed with schizotypal personality disorder (SPD) exhibit patterns of cognitive deficits, neuromotor disturbances, and behavior problems similar to individuals with schizophrenia, and thus SPD is thought to represent one point on the continuum of schizophrenia spectrum disorders (SSDs). Deficits in behavior, cognition, and motor functioning have been implicated as childhood precursors of SSDs and appear to also vary as a function of gender and family history of psychopathology. As such, studies of youth may help in further identification of individuals at risk for SSDs. The current study examined the prospective associations between problem behaviors, neuromotor and neurocognitive functioning, as well as SSD symptoms, at baseline and 2-year follow-up in youth meeting criteria for SPD, other personality disorders, or healthy controls. The neuromotor and neurocognitive measures were able to significantly predict SSD symptoms and behavior problems above and beyond baseline predictors. Overall, the findings provide further support for the role of subcortical motor centers operating together with prefrontal cortical areas in the regulation of higher-order cognitive functioning and in producing the psychiatric features of SSDs. Significant correlations between gender, family history of schizophrenia, and history of head injury with symptoms, behavior, cognition, and motor functioning were also found and highlight the importance of examining the effects of these variables in future investigations. In sum, the current study helped in identifying factors that predict the clinical course of schizotypy and may shed light on the disturbed neural circuitry underlying SSDs.

Religious beliefs and practices are an important source of symptom relief for individuals with schizophrenia; however, it can also be a debilitating source of symptom exacerbation. This quantitative study examined the cognitions and religious life orientations of Christian individuals both with and without a diagnosis of schizophrenia, as measured by the Rust Inventory of Schizotypal Cognitions (RISC) and the Religious Life Inventory (RLI) to examine a baseline for healthy religious cognitions. The aberrant-salience and attribution theories were used to explore the relationship between psychotic stimuli and religious attributions. One hundred and thirty Christian individuals from an outpatient mental health facility, both with and without a diagnosis of schizophrenia completed the RISC and the RLI. A t-test showed that individuals with schizophrenia scored higher on average on the schizotypal cognitions continuum than individuals without a diagnosis. The results of an ANOVA indicated that individuals with a Quest religious life orientation rendered higher scores on the schizotypal cognitions scale. This research study showed that higher levels of schizotypal cognitions were associated with low religiosity. Overall, individuals with schizophrenia showed no difference in religiosity compared to individuals without schizophrenia. This study addressed the stigma of religious practice among individuals with schizophrenia. Results of this study have positive social implications for individuals with schizophrenia and their practitioners/clergy who incorporate religion as a coping method for symptom relief.

Theories embedded within evolutionary neurobiology offer useful frameworks within which to understand cognitive impairment in schizophrenia (SCZ). The current research invokes the Dual Trends Theory (DTT), an evolutionary model that posits that neural architecture develops along two separate pathways: the dorsal ‘archicortical’ trend and the ventral ‘paleocortical’ trend. Although various lines of research converge to suggest that SCZ is associated with dorsal trend impairment in the context of relative ventral trend sparing, one persistent inconsistency exists. Specifically, individuals with SCZ routinely show impairment on tasks of action inhibition (AI; the ability to inhibit a pre-planned movement), a function routinely shown to be mediated by the inferior frontal gyrus, a key structure of the ventral trend. Here we argue that conventional tasks of AI conflate AI per se with response conflict (CON) demands, a function shown to be mediated by the anterior cingulate cortex, a key structure of the dorsal trend. We define CON as any aspect of a task that increases the difficulty of deciphering or interpreting the meaning of task stimuli (e.g., greater perceptual similarity between imperative task stimuli). The current research administered novel AI tasks in order to independently examine increases in CON and increases in the prepotency to respond to a pre-planned movement (PREP; considered a more fundamental measure of AI). Consistent with study hypotheses, individuals with Schizoprenia-spectrum disorders (specifically schizotypy) failed to show compensatory response time (RT) slowing when confronted with increasing CON demands yet showed proportional RTs, relative to healthy control participants, as PREP demands increased. These findings were interpreted as reflecting impairment in their ability to detect and/or decipher CON. More broadly, these findings suggest that cognitive abnormalities in SCZ may represent disproportionately impaired dorsal trend circuitry.

Theories embedded within evolutionary neurobiology offer useful frameworks within which to understand cognitive impairment in schizophrenia (SCZ). The current research invokes the Dual Trends Theory (DTT), an evolutionary model that posits that neural architecture develops along two separate pathways: the dorsal ‘archicortical’ trend and the ventral ‘paleocortical’ trend. Although various lines of research converge to suggest that SCZ is associated with dorsal trend impairment in the context of relative ventral trend sparing, one persistent inconsistency exists. Specifically, individuals with SCZ routinely show impairment on tasks of action inhibition (AI; the ability to inhibit a pre-planned movement), a function routinely shown to be mediated by the inferior frontal gyrus, a key structure of the ventral trend. Here we argue that conventional tasks of AI conflate AI per se with response conflict (CON) demands, a function shown to be mediated by the anterior cingulate cortex, a key structure of the dorsal trend. We define CON as any aspect of a task that increases the difficulty of deciphering or interpreting the meaning of task stimuli (e.g., greater perceptual similarity between imperative task stimuli). The current research administered novel AI tasks in order to independently examine increases in CON and increases in the prepotency to respond to a pre-planned movement (PREP; considered a more fundamental measure of AI). Consistent with study hypotheses, individuals with Schizoprenia-spectrum disorders (specifically schizotypy) failed to show compensatory response time (RT) slowing when confronted with increasing CON demands yet showed proportional RTs, relative to healthy control participants, as PREP demands increased. These findings were interpreted as reflecting impairment in their ability to detect and/or decipher CON. More broadly, these findings suggest that cognitive abnormalities in SCZ may represent disproportionately impaired dorsal trend circuitry.

The present study aimed to investigate the influences of socio-cultural context on content of delusions within schizophrenic patients among three different geographical areas in Saudi Arabia and to estimate the prevalence of schizotypal personality within the non-clinical Saudi population. Methods: 148 patients meeting DSM-IV criteria of schizophrenia were drawn from in-patient sections of mental health hospitals in three areas of study (Riyadh, Jeddah, and the Eastern Province), and 364 participants were recruited for comparison groups from Saudi universities and general medical practices in the same areas. The study utilized the following instruments: Scale for the Assessment of Positive Symptoms (SAPS), Scale for the Assessment of Negative Symptoms (SANS), the MacArthur-Maudsley Delusions Assessment Schedule (MMDAS), the World Health Organization (WHO) Life Events Schedule, the Aetiological Beliefs Questionnaire (ABQ), and the Schizotypal-Personality Questionnaire (SPQ). Results: Firstly: there were significant main effects of residence and sex on the three dependent SPQ scales, and females and Riyadh area residents scored higher on all dependent SPQ scales especially on the cognitive scale. Secondly: persecutory delusions were the most common delusions among schizophrenic patients followed by delusions of being controlled, and the frequency of persecutory delusions was significantly higher in females and in the Riyadh area. Thirdly: only delusions of jealousy were specifically associated with violent behaviours among schizophrenic patients. Finally: ABQ showed that both supernatural and psychological explanations of illness were common among both control and clinical groups. Qualitative analysis of the content of delusions revealed socio-cultural and gender-related issues that were strongly reflected in the themes and content of delusions. Conclusion: Content analysis of delusions in a Saudi schizophrenic sample showed strong effects of the socio-cultural context and stress points such as racism and gender inequality, and gender and regional culture affected both the frequency with which persecutory delusions were observed, and the mean scores of schizotypal personality in a non-clinical sample.

The current study provides convergent, discriminant, and incremental validity data for a measure of schizotypia from the perspective of the Five-Factor Model (FFM) of general personality structure. Nine schizotypia facet scales were constructed as maladaptive variants of respective facets of the FFM (e.g., Aberrant Ideas as a maladaptive variant of FFM Openness to Ideas). On the basis of data from 143 undergraduates the convergent validity of these nine facet scales was tested with respect to 11 established measures of schizotypia and the respective facets of the FFM. Discriminant validity was tested with respect to other personality disorders and facets from other FFM domains. Incremental validity was tested with respect to the ability of the FFM schizotypia facet scales to account for variance in two established measures of schizotypia, after variance accounted for by respective FFM facets and other established measures of schizotypia were first removed. The findings support the validity of these new facet scales as measures of schizotypia and as maladaptive variants of the FFM.

Thesis (Ph. D.)--University of California, San Diego, 2007. / Title from first page of PDF file (viewed November 7, 2007). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.

Thesis (Ph. D.)--State University of New York at Binghamton, Department of Psychology, 2006. / Includes bibliographical references.

No description available.

Borderline personality disorder (BPD) and schizotypal personality disorder (SPD) are both characterized by inflexible and pervasive behavioral patterns that frequently lead to significant functional impairment. Although considerable research has been conducted on the biological and phenotypic aspects of these disorders, researching, diagnosing, and treating them remains a challenge, primarily due to the difficulties associated with the categorical nature of current diagnostic methods (Skodol and Bender, 2009) which, in turn, results in significant within-group heterogeneity and between-group co-occurrence. Given the relative paucity of research comparing aspects of these disorders with one another, the current study aimed to evaluate overlapping and differentiating aspects of BPD and SPD by examining the integrity of a brain region frequently implicated in both disorders, the cingulum. The current study used a 3T Siemens scanner to acquire structural and diffusion tensor imaging in age-, sex-, and education-matched groups of 28 adults with BPD, 32 adults with SPD, and 36 healthy control participants (HC). The anterior and posterior cingulate were manually traced on all participants and then volume and fractional anisotropy (FA) comparisons were conducted across the groups for the left and right anterior and posterior cingulate. Compared with HC, SPD patients had smaller relative cingulate white matter volume and BPD patients had marginally significantly smaller relative cingulate white matter volume, and the two patient groups did not differ from one another. With regard to FA findings, a spectrum pattern emerged, such that the BPD group had significantly lower FA in the posterior cingulum relative to controls, whereas the SPD group also had lower FA in this region but did not differ from HC. The BPD group had marginally lower FA in dorsal aspects of the anterior cingulum when compared with HC, and the SPD patients did not differ from HC or BPD individuals. In summary, the current study provides evidence of aberrant connectivity of the cingulum in BPD patients, but not SPD patients, compared with HC individuals. Consistent with prior work, overall results suggest potential involvement of cingulum in BPD symptomatology. / Psychology