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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

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Showing 1 to 2 of 2 (0.101 seconds)
1

Effects of Bt transgenes on herbivorous insect-parasitoid interactions / Einfluss der transgenen Bt-Pflanzen auf Herbivor-Parasitoid-Interaktionen

Steinbrecher, Isolde 16 July 2004 (has links)
No description available.
630 Landwirtschaft
Veterinärmedizin
Agricultural Sciences
Bt-Kulturpflanzen
Nichtzielorganismen
natürliche Gegenspieler
Parasitoide
GVO
Umweltwirkungen
tritrophische Interaktionen
Windtunnel
sekundäre Pflanzeninhaltsstoffe
Bt crops
non-target organismen
natural enemies
parasitoids
GMO
biosafety
tritrophic interactions
wind tunnel
secondary plant metabolites
48.63
48.54
2

Direct Activation of TRPC3 Channels by the Antimalarial Agent Artemisinin

Urban, Nicole, Schaefer, Michael 17 April 2023 (has links)
(1) Background: Members of the TRPC3/TRPC6/TRPC7 subfamily of canonical transient receptor potential (TRP) channels share an amino acid similarity of more than 80% and can form heteromeric channel complexes. They are directly gated by diacylglycerols in a protein kinase C-independent manner. To assess TRPC3 channel functions without concomitant protein kinase C activation, direct activators are highly desirable. (2) Methods: By screening 2000 bioactive compounds in a Ca2+ influx assay, we identified artemisinin as a TRPC3 activator. Validation and characterization of the hit was performed by applying fluorometric Ca2+ influx assays and electrophysiological patch-clamp experiments in heterologously or endogenously TRPC3-expressing cells. (3) Results: Artemisinin elicited Ca2+ entry through TRPC3 or heteromeric TRPC3:TRPC6 channels, but did not or only weakly activated TRPC6 and TRPC7. Electrophysiological recordings confirmed the reversible and repeatable TRPC3 activation by artemisinin that was inhibited by established TRPC3 channel blockers. Rectification properties and reversal potentials were similar to those observed after stimulation with a diacylglycerol mimic, indicating that artemisinin induces a similar active state as the physiological activator. In rat pheochromocytoma PC12 cells that endogenously express TRPC3, artemisinin induced a Ca2+ influx and TRPC3-like currents. (4) Conclusions: Our findings identify artemisinin as a new biologically active entity to activate recombinant or native TRPC3-bearing channel complexes in a membrane-confined fashion.
info:eu-repo/classification/ddc/570
ddc:570

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