<p>Variation of diabetes incidence over time in countries with different incidence levels and socio-economic conditions, and in an age span beyond the childhood years, may give clues for diabetes causes.</p><p><i>Materials:</i> Data from prospective type 1 diabetes registers in Sweden and Lithuania in children (0-14 years) and young adults (15-34 and 15-39 years, respectively). Number of infections recorded in health care booklets (117 cases; 270 controls); interview about the dietary intake one-year before the diagnosis and routinely recorded growth data (99 cases; 180 controls). </p><p><i>Results:</i> The incidence of type 1 diabetes in Sweden and Lithuania differed most in the younger age groups, 28.9 and 7.5/100,000/year in 0-14-year group, respectively. During 1983-2000 incidence increased in 0-14-year old children in both countries, but the pattern of change differed. During 1983-1998 the incidence increased in Swedish children, but tended to decrease in young adults, with no increase in the age group below 35 years, indicating that the increase of childhood diabetes may be due to a shift towards a younger age at diagnosis. Within a low-incidence country Lithuania there was an urban-rural gradient of incidence, especially in the younger age groups, that seemed to follow poverty distribution: incidence in the 0-39-year group was 7.1, 9.0 and 8.8/100,000/year in rural areas, towns and cities, respectively, p<0.001.</p><p>Exposure to one or more non-specific infection during the first half-year of life reduced diabetes risk: odds ratios (95%-CI) in 0-14 and 5-14-year groups were (0.60; 0.37-0.98) and (0.47; 0.26-0.87), respectively. Higher energy intake and weight-for-age were independent diabetes risk factors: odds ratios for medium and high levels of energy were 1.33 (0.52-3.42) and 5.23 (1.67-16.38), and for weight-for-age 3.20 (1.30-7.88) and 3.09 (1.16-8.22), respectively. High intake of carbohydrates, disaccharides and sucrose in particular, increased diabetes risk independently of the high intake of energy.</p><p><i>Conclusion:</i> Environmental factors associated with socio-economic conditions in childhood may be important for the occurrence of type 1 diabetes. Lack of exposure to microbial antigens early in life, higher intake of energy and more rapid growth may contribute to the increase of childhood-onset diabetes observed in many countries.</p>

Variation of diabetes incidence over time in countries with different incidence levels and socio-economic conditions, and in an age span beyond the childhood years, may give clues for diabetes causes. Materials: Data from prospective type 1 diabetes registers in Sweden and Lithuania in children (0-14 years) and young adults (15-34 and 15-39 years, respectively). Number of infections recorded in health care booklets (117 cases; 270 controls); interview about the dietary intake one-year before the diagnosis and routinely recorded growth data (99 cases; 180 controls). Results: The incidence of type 1 diabetes in Sweden and Lithuania differed most in the younger age groups, 28.9 and 7.5/100,000/year in 0-14-year group, respectively. During 1983-2000 incidence increased in 0-14-year old children in both countries, but the pattern of change differed. During 1983-1998 the incidence increased in Swedish children, but tended to decrease in young adults, with no increase in the age group below 35 years, indicating that the increase of childhood diabetes may be due to a shift towards a younger age at diagnosis. Within a low-incidence country Lithuania there was an urban-rural gradient of incidence, especially in the younger age groups, that seemed to follow poverty distribution: incidence in the 0-39-year group was 7.1, 9.0 and 8.8/100,000/year in rural areas, towns and cities, respectively, p&lt;0.001. Exposure to one or more non-specific infection during the first half-year of life reduced diabetes risk: odds ratios (95%-CI) in 0-14 and 5-14-year groups were (0.60; 0.37-0.98) and (0.47; 0.26-0.87), respectively. Higher energy intake and weight-for-age were independent diabetes risk factors: odds ratios for medium and high levels of energy were 1.33 (0.52-3.42) and 5.23 (1.67-16.38), and for weight-for-age 3.20 (1.30-7.88) and 3.09 (1.16-8.22), respectively. High intake of carbohydrates, disaccharides and sucrose in particular, increased diabetes risk independently of the high intake of energy. Conclusion: Environmental factors associated with socio-economic conditions in childhood may be important for the occurrence of type 1 diabetes. Lack of exposure to microbial antigens early in life, higher intake of energy and more rapid growth may contribute to the increase of childhood-onset diabetes observed in many countries.

Determination sex is one of the most important tasks in the identification of skeletal remains. Previous studies have shown that population differences in size and shape of femora can affect correct sex allocation. This thesis tested the discriminat functions generated from different populations and confirmed population specificity of the femur discriminant functions. Two samples of the identified adult femora for this project was used. First sample originates from the Czech population living in the 1st 20th century (78 males and 81 females) and second sample originates from the Czech population living in the 2nd 20th century (67 males and 35 females). Both samples also help us estimate the influence of secular trend of the femur'variables to the correct sex classification by discriminat functions calculated in the Czech population. The results showed the existence of the secular trend in femora size dimensions. Only the dimensions of the femoral head (vertical head diameter-F18, transverse head diameter-F19 and maximum diameter of the femoral head-MPH) and sagittal subtrochanteric diameter (F10) not chandged significantly during the 20th century. The secular trend has negatively influenced the correct sex classification, always for one subpopulation. Only the dimensions in which the secular trend...

Submitted by Kelson Anthony de Menezes (kelson@ucb.br) on 2017-03-09T13:15:57Z No. of bitstreams: 1 NoribertoBarbosadaSilvaTese2016.pdf: 1669821 bytes, checksum: 87c9c73295ea1f195b7430a914ec0f3b (MD5) / Made available in DSpace on 2017-03-09T13:15:57Z (GMT). No. of bitstreams: 1 NoribertoBarbosadaSilvaTese2016.pdf: 1669821 bytes, checksum: 87c9c73295ea1f195b7430a914ec0f3b (MD5) Previous issue date: 2016-12-06 / Introduction: Technological evolutions in the modern world have caused significant changes in the way children and adolescents perform their amusements and leisure, leading to a reduction in the level of physical activity and impairing the formation of healthy habits. There is evidence that the level of physical fitness of children and adolescents has declined over time. In this sense studies that verify the secular trend of growth and physical fitness gain importance. Objective: to analyze, through a secular tendency, changes occurred in parameters of physical fitness related to health in schoolchildren from 7 to 12 years of age in the city of Taguatinga- DF, from 1992 to 2015. Materials and Methods: The study addresses With a sample of 2,281students (1,114 males and 1,167 females), from 2001 to 2005 (years 2000) with 774 students (348 boys and 426 girls) and Year of 2015 with 370 students (187 boys and 183 girls), totaling 3,425 students (1649 boys and 1,776 girls). Body mass and height were obtained, which gave rise to the body mass index, tricipital and subscapular skinfolds, with which the percentage of fat was calculated, in addition to agility, flexibility, lower limb strength and sexual maturation. Means, deviations and frequency were analyzed. Normality was verified with Shapiro Wilks and Kolmogorov-Smirnov. In addition to the analysis of variance in case of normality and Kruskal Wallis where there was no normality. The study was approved by the Ethics Committee of the Catholic University of Brasilia under number 1,086,406. Results: Body mass, height, body mass index and fat percentage of boys and girls presented significant differences when we compared the three moments of the study. These variables showed a positive secular trend, mainly when we compare the years 1990 and the year 2015. The results also show that when compared with reference tables for ages and sex the majority are classified in unsatisfactory levels. The variables flexibility and horizontal jump presented a seculartendency negative, demonstrating a worsening of results over time. There was also worsening in the variable agility that presented a positive secular tendency. It was found that the boys in the sample are initiating the process of sexual maturation earlier than the girls. The boys presented better performance in all stages of sexual maturation, except for the variable flexibility, where the girls were better. Conclusions: In a qualitative analysis, the results of the secular trend of both physical growth and motor performance of boys and girls presented worse results when we compared the first moment of the study (1990s) with the present moment (2015). It is suggested a great attention to the objectives of the Physical Education classes at the Public School and a pedagogical supervision to the teachers who teach this discipline. / Introdu????o: As evolu????es tecnol??gicas ocorridas no mundo moderno provocaram mudan??as significativas na forma como crian??as e adolescentes realizam suas divers??es e lazer, levandoos ?? diminui????o do n??vel de atividade f??sica e prejudicando a forma????o de h??bitos saud??veis. H?? evid??ncias que o n??vel de aptid??o f??sica das crian??as e dos adolescentes tem diminu??do com o tempo. Neste sentido estudos que verifiquem a tend??ncia secular do crescimento e da aptid??o f??sica ganham import??ncia. Objetivo: analisar, por meio de tend??ncia secular, modifica????es ocorridas em par??metros da aptid??o f??sica relacionada ?? sa??de em escolares de 07 a 12 anos de idade na cidade de Taguatinga-DF, no per??odo de 1992 a 2015. Materiais e M??todos: O estudo aborda tr??s momentos distintos, de 1992 a 1995 (anos 1990) com uma amostra de 2.281 alunos(1.114 do sexo masculino e 1,167 do sexo feminino), de 2001 a 2005 (anos 2000) com 774 alunos (348 meninos e 426 meninas) e do ano de 2015 com 370 alunos (187 meninos e 183 meninas), totalizando 3.425 alunos (1649 meninos e 1.776 meninas). Foram coletados massa corporal e estatura, que deram origem ao ??ndice de massa corporal, dobras cut??neas tricipital e subescapular, com as quais foi calculado o percentual de gordura, al??m da agilidade, flexibilidade, for??a de membros inferiores e matura????o sexual. Foram analisadas m??dias, desvios e frequ??ncia. A normalidade foi verificada com Shapiro Wilks e Kolmogorov-Smirnov. Al??m da an??lise de vari??ncia em caso de normalidade e Kruskal Wallis onde n??o houve normalidade. O estudo foi aprovado pelo Comit?? de ??tica da Universidade Cat??lica de Bras??lia sob o n??mero 1.086.406. Resultados: A massa corporal, a estatura, o indice de massa corporale o percentual de gordura dos meninos e das meninas apresentaram diferen??as significativas quando comparamos os tr??s momentos do estudo. Estas variaveis apresentaram tend??ncia secular positiva, principalemtne quando comparamos os anos 1990 e o ano de 2015. Os resultados tamb??m mostram que quando comparados com tabelas referenciais para as idades e sexo a maioria est??o classificados em niveis insatisfat??rios. As vari??veis flexibilidade e salto horizontal apresentaram tendencia secular negativa, demonstrando uma piora de resultados ao longo do tempo. Tamb??m houve piora na variavel agilidade que apresentou tendencia secular positiva. Verificou-se que os meninos da amostra est??o iniciando mais cedo o processo de matura????o sexual do que as meninas. Os meninos apresentaram melhor desempenho em todos os est??gios de matura????o sexual, exceto para a variavel flexibilidade, onde as meninas foram melhores. Conclus??es: Numa an??lise qualitativa, os resultados de tendencia secular tanto de crescimento f??sico quanto de desempenho motor dos meninos e meninas apresentaram resultados piores quando comparamos o primeiro momento do estudo (anos 1990) com o momento atual (2015). Sugere-se uma aten????o muito grande aos objetivos das aulas de Educa????o F??sica a Escola P??blica e uma supervis??o pedag??gica aos professores que ministram esta disciplina.

The objective of the Dissertation was to describe, quantify and interpret to which degree the shape and size of the facial skeleton of people living in the territory of today's Czech Republic in the period from the Early Middle Ages to the present day, i.e. in the course of the approx. last 1200 years, have changed. In this time period, morphological differences between populations, changes in the sexual dimorphism, modularity and allometry of the facial skeleton were examined. The evaluation was based on CT-images of skulls from three historical populations, specifically from the Early Middle Ages, High Middle Ages and the early modern period. The current population was represented by CT-images of living people. We studied the facial skeletons of a total of 329 individuals, of which 183 were men and 146 women. The CT- images were used as a base for the creation of virtual 3D surface models. The facial skeleton was divided into three morphological units, which were further examined. These were the skeleton of the upper face, lower jaw and palate. The statistical processing was carried out applying methods of geometric morphometrics allowing the separate studying of the shape and size variability of the examined units. When comparing the size and shape differences between studied populations it is...