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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
11

Elucidation of plasmacytoid dendritic cell development

Netravali, Ilka Arun 04 June 2015 (has links)
Most currently defined hematopoietic progenitor pools are heterogeneous, contributing to uncertainty regarding the development of certain blood cells. The origins of plasmacytoid dendritic cells, for instance, have long been controversial and progenitors exclusively committed to this lineage have never been described. We show here that the fate of hematopoietic progenitors is determined in part by their surface levels of 9-O-acetyl sialic acid. Pro-plasmacytoid dendritic cells were identified as lineage negative 9-O-acetyl sialic acid low progenitors that lack myeloid and lymphoid potential but differentiate into pre-plasmacytoid dendritic cells. The latter cells are also lineage negative, 9-O-acetyl sialic acid low cells but are exclusively committed to the plasmacytoid dendritic cell lineage. Levels of 9-O-acetyl sialic acid provide a distinct way to define progenitors and thus facilitate the study of hematopoietic differentiation.
12

The carbohydrate moiety of casein.

Huang, Flora Yun-Ying. January 1963 (has links)
It is now generally accepted that casein is a heterogeneous material. Due to the development of more effective fractionation methods, the heterogeneity of casein is now known to be even more complicated than was indicated a few years ago. [...]
13

Mechanistic and Evolutionary Analyses of the Sialic Acid Synthase Family

Joseph, Dmitri Daniel Alexander January 2014 (has links)
Sialic acids are prevalent in many organisms and facilitate a range of cellular processes in both bacteria and mammals. Whilst a variety of sialic acids are present in nature, N-Acetylneuraminic acid (NANA) is the most common and plays a key role in the pathogenesis of a select number of neuroinvasive bacteria such as Neisseria meningitidis. These pathogens coat themselves with polysialic acids, mimicking the exterior surface of mammalian cells and consequentially concealing the bacteria from the host’s immune system. NANA is synthesised in prokaryotes via a condensation reaction between phosphoenolpyruvate and N-acetylmannosamine. This reaction is catalysed by the domain swapped, homodimeric enzyme, N-acetylneuraminic acid synthase (NANAS). Each NANAS monomer is comprised of two distinct domains; a catalytic domain linked to an antifreeze protein-like (AFPL) domain. This thesis outlines research into the role of the AFPL domain using a range of structural and kinetic analyses to compare variant enzymes to the natural, NmeNANAS enzyme. An investigation was also made into the evolutionary relationships between NANAS and other bacterial sialic acid synthases such as Legionaminic acid synthase and Pseudaminic acid synthase.
14

E. coli Fermentation for the Production of Sialic Acid

Zhi, Li 17 December 2013 (has links)
Sialic acid is the terminal sugar found on most glycoproteins and is crucial in determining serum half-life and immunogenicity on glycoproteins. The scarce supply of sialic acid hinders its advancement in basic research, diagnostic development and therapeutic production. In this work, the recombinant E. coli BRL04 (pBRL89) producing sialic acid was studied by some batch and fed batch runs of high cell density cultivation using a 3-L fermentor. Some cultivation conditions including carbon source, induction time, dissolved oxygen were optimized and different feeding strategies were compared to enhance sialic acid production. The results may be helpful to the further scale-up of sialic acid production and the production of other recombinant proteins by high cell density cultivation of E. coli.
15

Sialic acids and sialoglycoproteins in sperm and fluid of rat epididymis /

Prapaporn Toowicharanont. January 1982 (has links) (PDF)
Thesis (Ph.D. (Biochemistry))--Mahidol University, 1982.
16

Siglec-G is a negative regulator of NF-[kappa]B activation and has pivotal roles in B-1 cell development and resistance to sepsis /

Ding, Cheng. January 2008 (has links)
Thesis (Ph. D.)--Ohio State University, 2008. / Non-Latin script record
17

Structural studies on the sialidases from Streptococcus pneumoniae and Pseudomonas aeruginosa /

Xu, Guogang. January 2009 (has links)
Thesis (Ph.D.) - University of St Andrews, May 2009.
18

E. coli Fermentation for the Production of Sialic Acid

Zhi, Li January 2014 (has links)
Sialic acid is the terminal sugar found on most glycoproteins and is crucial in determining serum half-life and immunogenicity on glycoproteins. The scarce supply of sialic acid hinders its advancement in basic research, diagnostic development and therapeutic production. In this work, the recombinant E. coli BRL04 (pBRL89) producing sialic acid was studied by some batch and fed batch runs of high cell density cultivation using a 3-L fermentor. Some cultivation conditions including carbon source, induction time, dissolved oxygen were optimized and different feeding strategies were compared to enhance sialic acid production. The results may be helpful to the further scale-up of sialic acid production and the production of other recombinant proteins by high cell density cultivation of E. coli.
19

Sialic acids: their in vitro and in vivo inhibitation of antibody-antigen agglutinogen reactions

Rule, Allyn L. January 1965 (has links)
Thesis (Ph.D.)--Boston University / PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you. / The in vitro relationship of sialic acids to the A, B, M, N, C, D, and E antigens of the human erythrocyte has been studied by means of the Landsteiner hapten inhibition test with the idea that substances that strongly inhibit anti-D might find practical application in the prevention and treatment of erythroblastosis fetalis. Our results suggest that N-acetyl neuraminic acid (NANA) is a major constituent of the D (Rh0), M, and N agglutinogens, a minor constituent of the A antigen, but is probably not a functional portion of the B, C, and E antigenic structures. [TRUNCATED] / 2031-01-01
20

The carbohydrate moiety of casein.

Huang, Flora Yun-Ying. January 1963 (has links)
No description available.

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